Updated facts on the U.S. distributions of earnings, income, and wealth

Wealth ; Income distribution

HySEA model verification for Tohoku 2011 Tsunami. Application for mitigation tsunami assessment

In many aspects Tohoku-Oki 2011 mega tsunami has changed our perception of tsunami risk. The tsunami-HySEA model is used to numerically simulate this event and observed data will we used to verify the model results. Three nested meshes of enhanced resolution (4 arc-min, 32 arc-sec and 2 arc-sec) will be used by the numerical model. The propagation mesh covers all Pacific Ocean with more of 7 million cells. An intermediate mesh with 5 millions cells contains the Japanese archipelago and, finally, two finer meshes, with nearly 8 and 6 millions cells, cover Iwate and Miyagi Prefectures at Tohoku region, the most devastated areas hit by the tsunami. The presentation will focus on the impact of the tsunami wave in these two areas and comparisons with observed data will be performed. DART buoys time series, inundation area and observed runup is used to assess model performance. The arrival time of the leading flooding wave at the vicinity of the Senday airport, as recorded by video cameras, is also used as verification data for the model. After this tsunami, control forests as well as breakwaters has been discussed as suitable mitigation infrastructures. As particular case, we will analyse the evolution of the tsunami in the area around the Sendai airport (Miyagi Prefecture) and its impact on the airport. A second simulation has been performed, assuming the existence of a coastal barrier protecting the area. The role of this barrier in modifying tsunami wave evolution and mitigating flooding effects on the airport area are discussed. The protection effect of the breakwaters near Kamaishi (Iwate Prefecture) is also assessed. The numerical model shows how these structures, although did not provide a full protection to tsunami waves, they helped to largely mitigate its effects in the area.Acknowledgements. This research has been partially supported by the Junta de Andalucía research project TESELA (P11-RNM7069), the Spanish Government Research project DAIFLUID (MTM2012-38383-C02-01) and Universidad de Málaga, Campus de Excelencia Internacional Andalucía Tech. The multi-GPU computations were performed at the Laboratory of Numerical Methods (University of Malaga)

Elasticidad de la demanda de estacionamiento ante variaciones sistemáticas del ingreso en Montería, Colombia

This article analyzes on-street and private parking lots demand elasticityin the central business district of Monteria, Colombia, when fee andincome variations are considered.Estimated choice models were based on a stated preference survey.Elasticities were analyzed using a multinomial logit model, whichexplanatory variables were travel time, access time, fee and income.It was found that demand and income elasticities were -0,10 and -0,32for on-street and private parking lot, respectively. Those elasticitiesexperienced a 33,5 % change when users’ income variations are considered.This shows that a restrictive parking management policy wouldaffect lower income groups.El presente artículo analiza la elasticidad de la demanda de estacionamientosobre la vía pública y en parqueadero privado en la zona céntricade la ciudad de Montería, Colombia, considerando variaciones en latarifa y en el nivel de ingreso de los usuarios.Los modelos fueron estimados con base en datos de preferencias declaradas.Las elasticidades fueron analizadas con un modelo de tipo logitmultinomial, cuyas variables explicativas fueron el tiempo de viaje, eltiempo de acceso, el costo y el ingreso.Se encontró que las elasticidades entre la demanda y la tarifa fueronde -0,10 y -0,32 para parqueo sobre la vía pública y en parqueaderoprivado, respectivamente. Se evidenció además una diferencia del33,5 % en el valor de dichas elasticidades cuando son consideradasvariaciones de ingreso de los individuos. Esto muestra que una políticarestrictiva de gestión de precios de parqueo afectaría más a grupos conmenores ingresos

Experimental Stark widths and shifts of V II spectral lines

We have measured the Stark widths and shifts of V II spectral lines in the wavelength range 2000-4200 Å belonging to 75 multiplets. The spectra are emitted by laser-induced plasmas generated from fused glass discs prepared by borate fusion. The electron density and temperature are in the ranges (0.72-6.5) × 1017 cm-3 and (11 000-14 900) K, respectively. To avoid self-absorption, we have used seven samples with vanadium concentrations selected by the CSigma graph methodology. This has allowed to include strong and weak lines in the study, including resonance and forbidden lines. The experimental widths and shifts are compared with theoretical values available in the literature.Fil: Manrique Rosel, Javier. Universidad CEU San Pablo; EspañaFil: Diaz Pace, Diego Martin. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires. - Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Física e Ingeniería del Centro de la Provincia de Buenos Aires; ArgentinaFil: Aragón, Concepción. Universidad Publica de Navarra. Departamento de Ciencias.; EspañaFil: Aguilera Andoaga, Jose antonio. Universidad Publica de Navarra. Departamento de Ciencias.; Españ

Anadise : aula virtual para la Universidad Minuto de Dios

Por el análisis que se realizó en base a lo que se vivió como estudiante de la Universidad Minuto de Dios, se pudo concluir que hay gran necesidad referente a la eficacia del modo de enseñanza y aprendizaje que se aplican de las asignaturas que en sus contenidos temáticos son muy extensos y se estudian muchos textos teóricos. Se pudo ver con claridad que la Universidad necesita una herramienta de estudio más accesible para los estudiantes. Se ve tanto la falta de materiales para que el alumno pueda entender las materias como importantes métodos de apoyos para el entendimiento de todos los contenidos que se ven en cada asignatura. De acuerdo a lo presentado se formuló varias posibles soluciones que facilitaran realmente a la enseñanza y aprendizaje de estas materias. Como estudiantes de Informática de la Universidad Minuto de Dios, se ha diseñado, desarrollado y elaborado una herramienta de estudio para el aprendizajes de asignaturas, la cual es una aula virtual que trabaja con varios servicios y aplicaciones didácticas para todos los temas correspondientes que se ven en cada asignatura. Con el fin de poder ayudar a las nuevas generaciones de estudiantes, sabemos que con esta herramienta de estudio, su aprendizaje será aún más eficiente que como lo es en el tiempo presente

Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients

Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial cells contributes to disease pathogenesis. Here we analyze the differences in the microglial response between APP/PS1 model and human brains. Methods: RT-PCR, western blots, and immunostaining were performed in the hippocampus of human post mortem samples (from Braak II to Braak V-VI) and APP751SL/PS1M146L mice. In vitro studies to check the effect of S1 fractions on microglial cells were assayed. Results: In APP based models the high Abeta accumulation triggers a prominent microglial response. On the contrary, the microglial response detected in human samples is, at least, partial or really mild. This patent difference could simple reflect the lower and probably slower Abeta production observed in human hippocampal samples, in comparison with models or could reflect the consequence of a chronic long-standing microglial activation. However, beside this differential response, we also observed a prominent microglial degenerative process in Braak V-VI samples that, indeed, could compromise their normal role of surveying the brain environment and respond to the damage. This microglial degeneration, particularly relevant at the dentate gyrus of the hippocampal formation, might be mediated by the accumulation of toxic soluble phospho-tau species. Conclusions: These differences need to be considered when delineating animal models that better integrate the complexity of AD pathology and, therefore, guarantee clinical translation. Correcting dysregulated brain inflammatory responses might be a promising avenue to restore cognitive function. Supported by grants FIS PI15/00796 and FIS PI15/00957 co-financed by FEDER funds from European Union, and by Junta de Andalucia Proyecto de Excelencia CTS385 2035.Financiado por FIS PI15/00796 y FIS PI15/0095, cofinanciado por los fondos FEDER de la Unión Europea, y por Junta de Andalucia Proyecto de Excelencia CTS385 2035. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Microglial responses in the human Alzheimer’s disease frontal cortex

The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for this pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial cells contributes to AD pathogenesis. The actual view, based on the findings in APP based models, gives a cytotoxic/proinflammatory role to activated microglia. However, we have previously reported a limited activation and microglial degeneration in the hippocampus of AD patients in contrast with that observed in amyloidogenic models. Here, we evaluated the microglial response in a different region of AD brains, the frontal cortex. Post mortem tissue from controls (Braak 0-II) and AD patients (Braak V-VI) including familial cases, were obtained from Spain Neurological Tissue Banks. Cellular (immunohistochemistry and image analysis) and molecular (qPCR and western blots) approaches were performed. Frontal cortex of AD patients (Braak V-VI) showed strong microglial activation similar to that observed in amyloidogenic mice. These strongly activated microglial cells, predominantly located surrounding amyloid plaques, could drive the AD pathology and, in consequence, could be implicated in the pathology progression. Furthermore, different microglial responses were observed between sporadic and familial AD cases. These findings in the frontal cortex were highly in contrast to the attenuated activation and degenerative morphology displayed by microglial cells in the hippocampus of AD patients. Regional differences in the microglial response suggest different functional states of microglial cells in a region-specific manner. All together, these data provide a better understanding of the immunological mechanisms underlying AD progression and uncover new potential therapeutic targets to fight this devastating neurodegenerative disease.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech. Supported by PI18/01557 (AG) and PI18/01556 (JV) grants from ISCiii of Spain co-financed by FEDER funds from European Unio