Import Demand for Dairy Products in Cote d'Ivoire

We estimate an LA/AIDS model of demand for imported dairy products for Cote d'Ivoire. We employ a unique set of Ivorian customs data, spanning seven dairy products observed monthly from January 1996 to December 2005. Demand for milk powder is found to be inelastic, as substitutes for milk powder in the domestic processing industry are scarce. Demand for fluid milk, yogurt, and cream are found to be elastic, as these domestic products produced from imported powder may substitute for the imports. With the exception of condensed milk, dairy products are found to be necessities.International Relations/Trade,

Maternal and perinatal outcome of teenage deliveries in Bamako’s district

Background: We initiated this study for determining the maternal and fatal outcome of deliveries among the teenage to formulate the recommendations for reducing the maternal and neonatal morbidity and mortality among the teenage. We compared maternal and foetal outcome of deliveries among the teenage to that of adult women.Methods: It was a prospective analytical case/control study running in the Bamako’s district for 6 month comparing deliveries among one population of teenage elderly of 14-19 years and another population of women of 20 to 29 years having birth in our service hang the same period of the study. Used test statistics is the chi square of Pearson. For both groups we determined Odds Ratio (OR) and its interval of confidence (IC) to 95%.Results: We recorded 350 teenagers’ deliveries among 3703 deliveries (9.4%). The pelvic was normal among 66.3% of case versus 73.5% among the controls (p >0.05). The extended labor (≥12 hours) was found among 6.6% of case versus 3.3% of controls (p >0.05). We recorded 57.3% vaginal deliveries among the case versus 46.2% among the controls (p >0.05). We recorded 3 cases of maternal death all among the controls. 71% of new-born had an Apgar score ≥7 to the first minute among the case versus 81.2% among the controls. It was no significant difference in terms of vital outcome of new-born and of small weight birth in both groups (p >0.05).Conclusions: If teenage pregnancies are benefit the adequate prenatal care, there would be any significant difference between maternal and perinatal outcome of the deliveries among the teenage and of adult's people

MORINGA OLEIFERA LEAF POWDER FOR TYPE 2 DIABETES: A PILOT CLINICAL TRIAL

Background: Moringa oleifera Lam. (Moringaceae) leaves are commonly used for diabetes in Mali. This pilot clinical study aimed to evaluate its effect on post-prandial blood glucose in preparation for a larger trial. Methods: Diabetic patients and non-diabetic healthy volunteers (35 each) were asked to fast for 13 hours on three occasions. Blood glucose was measured before and after eating 100g of white bread (at 30, 60, 90, 120, 150 and 180 minutes). On their second and third study visits, they were given 1g and 2g respectively, of M. oleifera leaf powder, 30 minutes after eating the bread.  The mean paired reduction in blood glucose at each time interval and the incremental area under the curve were calculated. Results: Ingestion of Moringa powder had no effect on blood glucose in non-diabetic participants, but in diabetic patients, it lowered blood glucose at 90 minutes. There was a trend towards lower incremental area under the curve when diabetic patients took 2g of Moringa. No side-effects were reported by any participant. Conclusions: Moringa oleifera leaf powder reduced post-prandial glycaemia in diabetic patients. A larger study is needed to define the optimal dose and to assess whether this translates into longer-term benefits

Prévalence de la tuberculose et de la brucellose chez les animaux sélectionnés du projet d´appui au développement de l´élevage du Zébu maure (PRODEZEM) dans le cercle de Nara: Prevalence of tuberculosis and brucellosis in selected animals of the project to support the development of Moorish Zebu breeding (PRODEZEM) in the Nara circle

Introduction: La tuberculose et la brucellose bovines représentent des contraintes majeures au dévelop-pement de l’élevage bovin laitier au Mali. A Nara, pour fixer la race Zébu maure, le dépistage de ces deux maladies zoonotiques bovines a été entrepris sur les bovins du projet. L’objectif de ce travail était de déterminer leurs prévalences dans les noyaux sélectionnés. Méthodes: Une étude transversale de type descriptif a été menée sur les bovins des noyaux de zébus maures. Les tests de tuberculination et de Rose Bengale ont été effectués sur les bovins des noyaux du projet. Les prévalences de chaque maladie ont été obtenues en faisant le rapport entre le nombre de cas positif sur le nombre total d’animaux testés. Résultats: Au total, les tests de dépistage ont concerné 1112 sujets de 50 noyaux présélectionnés dans les cinq communes du cercle de Nara. Les prévalences de la tuberculose et la brucellose bovines sont respectivement de 0,90 % et de 0,27 %. Concernant la tuberculose, le maximum de cas a été observé à Niamana (4 cas) et le minimum à Guenéibe (1 cas). Par rapport à la brucellose, le maximum de cas a été enregistré dans la commune de Guiré (2 cas). Conclusion: Cette étude a montré de faibles taux d’infection de la tuberculose et de la brucellose chez les bovins du projet. L’étude a en outre permis d’avoir de nouvelles connaissances sur l’épidémiologie de ces maladies zoonotiques dans les noyaux sélectionnés du projet. Background: Bovine tuberculosis and brucellosis are major constraints to the development of dairy cattle farming in Mali. In Nara, in order to establish the Moorish Zebu breed, screening for these two zoonotic bovine diseases was undertaken on the cattle project. The objective of this study was to determine the prevalence in the selected nuclei. Methods: A descriptive cross-sectional study was conducted on cattle in the Moorish Zebu nuclei. Tuberculin and Rose Bengal tests were carried out on cattle in the project nuclei. The prevalence of each disease were obtained as the ratio of the number of positive cases to the total number of animals tested. Results: A total of 1112 animals from 50 pre-selected nuclei in the five communes of the Nara circle were tested. The prevalence of bovine tuberculosis and brucellosis were 0.90% and 0.27% respectively. As regards tuberculosis, the maximum number of cases was observed in Niamana (4 cases) and the minimum in Guenéibe (1 case). With regard to brucellosis, the maximum number of cases was recorded in the commune of Guiré (2 cases). Conclusion: This study showed low infection rates of tuberculosis and brucellosis in the project cattle. It also provided new insights into the epidemiology of these zoonotic diseases in the selected nuclei of the project

Variations saisonnières de la densité apparente et du taux d'infection par Trypanosoma spp. de <em>Glossina palpalis gambiensis</em> (Vanderplank, 1949) en zone soudanienne au Mali

Glossina palpalis gambiensis infeste les forêts ripicoles et les galeries forestières du fleuve Niger et ses affluents dans la zone agropastorale de Baguinéda-Tienfala. L'incidence de la trypanosomose (liée à la densité apparente de cette sous-espèce et à son infection trypanosomienne) variait en fonction de la saison et du gîte. En effet, au niveau du gîte de Tienfala (rive gauche du fleuve), la densité la plus élevée (21,70 glossines/piège/jour) a été observée en fin de saison des pluies, et la plus faible (5,23) en saison sèche chaude. La sex-ratio était en général en faveur des femelles (60,74 %). Au niveau du gîte de Baguinéda (rive droite), la densité la plus élevée (8,70) a été trouvée en saison sèche froide, et la plus faible (2,91) en fin de saison des pluies. La sex-ratio était en général en faveur des mâles (57,81 %). L'infection trypanosomienne était plus élevée en fin qu'en début de saison des pluies et les taux observés variaient respectivement entre 6,66 et 10,68 % contre 0,48 et 1,48 %. Déterminées d'après leur localisation chez G. palpalis gambiensis, les infections étaient dues aux sous-genres Duttonella (Trypanosoma vivax : 80 %), Nannomonas (T. congolense : 4%), Megatrypanum (T. grayi : 2 %) et à des stades immatures localisés dans l'intestin moyen uniquement (14 %)

Réactualisation des données sur la répartition des glossines au Mali

L'aire de répartition des glossines au Mali couvre environ 200 000 km2 au sud du parallèle 14 30' N et à l'ouest du méridien 4 30' O. Quatre espèces ont été signalées : deux riveraines (Glossina palpalis gambiensis et G. tachinoides) et deux de savane (G. morsitans submorsitans et G. longipalpis). G. morsitans submorsitans était répartie de manière plus ou moins continue le long des frontières avec la Côte d'Ivoire, la Guinée et le Sénégal jusqu'à la limite nord du parc national de la Boucle du Baoulé. A l'est de Bamako, la densité des populations était faible, apparemment discontinue dans les zones forestières. G. palpalis gambiensis était localisée le long de la rivière Bani, du fleuve Niger et de ses affluents, et des affluents du fleuve Sénégal (Baoulé, Bafing et Bagoé). G. tachinoides était répandue le long de la plupart des rivières et des grands cours d'eau de la partie sud-est du pays. Les prospections récentes n'ont pas revélé la présence de G. longipalpis au Mali. Après plusieurs années de sécheresse et/ou un défrichement intensif, une diminution relativement importante de l'aire de répartition des glossines dans le pays a été constatée

Pregnancy outcomes in a malaria-exposed Malian cohort of women of child-bearing age

In Sub-Saharan Africa, malaria continues to be associated with adverse pregnancy outcomes including stillbirth, early neonatal death, preterm delivery, and low birth weight. Current preventive measures are insufficient and new interventions are urgently needed. However, before such interventions can be tested in pregnant women, background information on pregnancy outcomes in this target population must be collected. We conducted an observational study in Ouélessébougou, Mali, a malaria-endemic area where first antenatal visit commonly occurs during the second trimester of pregnancy, hindering calculation of miscarriage rate in the population. To accurately determine the rate of miscarriage, 799 non-pregnant women of child-bearing age were enrolled and surveyed via monthly follow up visits that included pregnancy tests. Out of 505 women that completed the study, 364 became pregnant and 358 pregnancies were analyzed: 43 (12%) resulted in miscarriage, 28 (65.1%) occurred during the first trimester of pregnancy. We also determined rates of stillbirth, neonatal death, preterm delivery, and small for gestational age. The results showed high rate of miscarriage during the first trimester and established a basis to evaluate new interventions to prevent pregnancy malaria. This survey design enabled identification of first trimester miscarriages that are often missed by studies conducted in antenatal clinics.Clinical trial registration[https://clinicaltrials.gov/], identifier [NCT0297 4608]

Diagnostic accuracy of Xpert® MTB/RIF Ultra for childhood tuberculosis in West Africa - a multicentre pragmatic study

OBJECTIVE: To evaluate the performance of Xpert MTB/RIF Ultra ('Ultra') for diagnosis of childhood tuberculosis (TB) within public health systems. METHODS: In this cross-sectional study, children aged <15 years with presumptive pulmonary TB were consecutively recruited and evaluated for TB at tertiary-level hospitals in Benin, Mali and Ghana. Bivariate random-effects models were used to determine the pooled sensitivity and specificity of Ultra against culture. We also estimated its diagnostic yield against a composite microbiological reference standard (cMRS) of positive culture or Ultra. RESULTS: Overall, 193 children were included in the analyses with a median (IQR) age of 4.0 (1.1 - 9.2) years, 88 (45.6%) were female, and 36 (18.7%) were HIV-positive. Thirty-one (16.1%) children had confirmed TB, 39 (20.2%) had unconfirmed TB, and 123 (63.7%) had unlikely TB. The pooled sensitivity and specificity of Ultra verified by culture were 55.0% (95% CI: 28.0 - 79.0%) and 95.0% (95% CI: 88.0 - 98.0%), respectively. Against the cMRS, the diagnostic yield of Ultra and culture were 67.7% (95% CI: 48.6 - 83.3%) and 70.9% (95% CI: 51.9 - 85.8%), respectively. CONCLUSION: Ultra has suboptimal sensitivity in children with TB that were investigated under routine conditions in tertiary-level hospitals in three West African countries

Discrepant Prevalence and Incidence of Leishmania Infection between Two Neighboring Villages in Central Mali Based on Leishmanin Skin Test Surveys

Leishmaniasis is a vector-borne disease transmitted to humans by the bite of an infected sand fly. Leishmaniasis is present in more than 88 countries and affects more than 12 million people. Depending on the species of Leishmania, the host can develop cutaneous leishmaniasis (CL), which is characterized by skin ulcers in uncovered parts of the body or a more severe form, visceral leishmaniasis, which affects the liver and spleen and is fatal if not treated. This study aims to establish the past and present infection with Leishmania parasites in two villages where recent cases have been diagnosed by the dermatology center (CNAM) in Bamako. This was achieved using a Leishmania-specific skin test that was administered annually to permanent residents of Kemena and Sougoula villages from 2006 to 2008. The results show that transmission of Leishmania is active and stable in these two villages. Moreover, despite sharing similar cultural and environmental features, the individuals from Kemena presented three times the risk of Leishmania infection compared with those from Sougoula. Our findings raise awareness of the continued presence of CL in Mali

Prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa: a systematic review and meta-analysis

ObjectivesThis study aimed to determine the prevalence and factors associated with maternal and neonatal sepsis in sub-Saharan Africa.MethodsThis systematic review and meta-analysis used the PRISMA guideline on sepsis data in sub-Saharan Africa. The bibliographic search was carried out on the following databases: Medline/PubMed, Cochrane Library, African Index Medicus, and Google Scholar. Additionally, the reference lists of the included studies were screened for potentially relevant studies. The last search was conducted on 15 October 2022. The Joanna Briggs Institute quality assessment checklist was applied for critical appraisal. Estimates of the prevalence of maternal and neonatal sepsis were pooled using a random-effects meta-analysis model. Heterogeneity between studies was estimated using the Q statistic and the I2 statistic. The funnel plot and Egger’s regression test were used to assess the publication bias.ResultsA total of 39 studies were included in our review: 32 studies on neonatal sepsis and 7 studies on maternal sepsis. The overall pooled prevalence of maternal and neonatal sepsis in Sub-Saharan Africa was 19.21% (95% CI, 11.46–26.97) and 36.02% (CI: 26.68–45.36), respectively. The meta-analyses revealed that Apgar score &lt; 7 (OR: 2.4, 95% CI: 1.6–3.5), meconium in the amniotic fluid (OR: 2.9, 95% CI: 1.8–4.5), prolonged rupture of membranes &gt;12 h (OR: 2.8, 95% CI: 1.9–4.1), male sex (OR: 1.2, 95% CI: 1.1–1.4), intrapartum fever (OR: 2.4, 95% CI: 1.5–3.7), and history of urinary tract infection in the mother (OR: 2.7, 95% CI: 1.4–5.2) are factors associated with neonatal sepsis. Rural residence (OR: 2.3, 95% CI: 1.01–10.9), parity (OR: 0.5, 95% CI: 0.3–0.7), prolonged labor (OR: 3.4, 95% CI: 1.6–6.9), and multiple digital vaginal examinations (OR: 4.4, 95% CI: 1.3–14.3) were significantly associated with maternal sepsis.ConclusionThe prevalence of maternal and neonatal sepsis was high in sub-Saharan Africa. Multiple factors associated with neonatal and maternal sepsis were identified. These factors could help in the prevention and development of strategies to combat maternal and neonatal sepsis. Given the high risk of bias and high heterogeneity, further high-quality research is needed in the sub-Saharan African context, including a meta-analysis of individual data.Systematic review registration: PROSPERO (ID: CRD42022382050)