Ética de los sentimientos, desarrollo de capacidades, memoria histórica y reconciliación: la fragilidad del personal de salud en el conflicto armado colombiano

Objectiu: analitzar la manera com els sentiments i la recuperació de la memòria col·lectiva, possibiliten la disminució de la fragilitat social i política dels integrants de la Missió Mèdica, fent factible noves maneres de participació, mitjançant el desenvolupament de capacitats deliberatives des de la perspectiva bioètica. Metodologia: estudi exploratori amb enfocament qualitatiu, que té en compte la subjectivitat i la intersubjectivitat dels participants. Amb fonts d'informació heterogènia: grups focals, entrevistes semiestructurades i cartilles de camp, es va constituir un marc de factors rellevants, que van permetre processar la informació, mitjançant relacions i categoritzacions conceptuals, per triangular-les posteriorment. Resultats: els sentiments amb més impacte ètic a Missió Mèdica: incertesa, inseguretat davant la feina, ansietat pels fets de violència, tristesa, temor, por i impotència; produeixen efectes emocionals relacionats amb el principi de maleficència. La resiliència, ha impedit fer exercicis de memòria col·lectiva, a causa del negacionisme i temor de recordar els fets més significatius, això els ha impedit l'accés als mecanismes de Justícia Restaurativa. L'absència de capacitats per fer front a la situació compromet l'autonomia individual, la salut laboral i genera mancances legals no resoltes. Conclusions: els sentiments col·lectius en l'àmbit públic del personal sanitari prevalen sobre els sentiments individuals basats en vivències, que afecten la capacitat de deliberació, això implica promoure exercicis de memòria col·lectiva, sobre els fets del conflicte, mitjançant el desenvolupament de capacitats que enforteixin la legítima defensa de la seva autonomia i el desenvolupament d'un exercici professional beneficient, davant de situacions limítrofes de confrontació.Objective: to analyze the way in which feelings and the recovery of collective memory make it possible to reduce the social and political fragility of the members of the Medical Mission, making new ways of participation feasible, through the development of deliberative capacities from a bioethical perspective. Methodology: exploratory study with qualitative approach, which considers the subjectivity and intersubjectivity of the participants. With heterogeneous sources of information: focus groups, semi-structured interviews and field primers, a framework of relevant factors was constituted, which allowed processing the information, through conceptual relationships and categorizations, for its subsequent triangulation. Results: the feelings with the greatest ethical impact in Mission Medical: uncertainty, insecurity at work, anxiety due to acts of violence, sadness, fear, fear, and impotence; produce emotional effects related to the principle of maleficence. Resilience has prevented them from carrying out collective memory exercises, due to denial and fear of remembering the most significant events, which has prevented them from accessing Restorative Justice mechanisms. The absence of capacities to face the situation compromises individual autonomy, occupational health and generates unresolved legal shortcomings. Conclusions: collective feelings in the public sphere of health personnel prevail over individual feelings based on experiences, which affect the capacity for deliberation, this implies promoting exercises of historical memory on the facts of the conflict, through the development of capacities that strengthen the legitimate defense of their autonomy and the development of a beneficial professional exercise, in the face of borderline situations of confrontation.Objetivo: analizar la forma en que los sentimientos y la recuperación de la memoria colectiva, posibilitan la disminución de la fragilidad social y política de los integrantes de la Misión Médica, haciendo factible nuevas maneras de participación, mediante el desarrollo de capacidades deliberativas desde la perspectiva bioética. Metodología: estudio exploratorio con enfoque cualitativo, que toma en cuenta la subjetividad e intersubjetividad de los participantes. Con fuentes de información heterogénea: grupos focales, entrevistas semiestructuradas y cartillas de campo, se constituyó un marco de factores relevantes, que permitieron procesar la información, mediante relaciones y categorizaciones conceptuales, para su posterior triangulación. Resultados: los sentimientos con mayor impacto ético en Misión Médica: incertidumbre, inseguridad ante el trabajo, ansiedad por los hechos de violencia, tristeza, temor, miedo e impotencia; producen efectos emocionales relacionados con el principio de maleficencia. La resiliencia, ha impedido realizar ejercicios de memoria colectiva, a causa del negacionismo y temor a recordar los hechos más significativos, esto les ha impedido el acceso a los mecanismos de Justicia Restaurativa. La ausencia de capacidades para afrontar la situación compromete la autonomía individual, la salud laboral y genera carencias legales no resueltas. Conclusiones: los sentimientos colectivos en el ámbito público del personal sanitario prevalecen sobre los sentimientos individuales basados en vivencias, que afectan la capacidad de deliberación, esto implica promover ejercicios de memoria colectiva, sobre los hechos del conflicto, mediante el desarrollo de capacidades que fortalezcan la legitima defensa de su autonomía y el desarrollo de un ejercicio profesional beneficiente, ante situaciones limítrofes de confrontación

Image-guided versus blind corticosteroid injections in adults with shoulder pain: A systematic review

<p>Abstract</p> <p>Background</p> <p>Corticosteroid injections can be performed blind (landmark-guided) or with image guidance, and this may account for variable clinical outcomes. The objective of this study was to assess the effectiveness and safety of image-guided versus blind corticosteroid injections in improving pain and function among adults with shoulder pain.</p> <p>Methods</p> <p>MEDLINE, the Cochrane Controlled Trials Register and EMBASE were searched to May 2010. Additional studies were identified by searching bibliographies of shortlisted articles. Search items included blind, landmark, anatomical, clinical exam, image-guided, ultrasound, fluoroscopy, steroid injection, frozen shoulder, random allocation, randomized controlled trial (RCT) and clinical trial.</p> <p>Randomized controlled studies comparing image-guided versus blind (landmark-guided) corticosteroid shoulder injections that examined pain, function and/or adverse events were included. Independent extraction was done by two authors using a form with pre-specified data fields, including risk of bias appraisal. Conflicts were resolved by discussion. The decision to pool data was based on assessment of clinical design homogeneity. When warranted, studies were pooled under a random-effects model.</p> <p>Results</p> <p>Two RCTs for pain, function and adverse events (n = 101) met eligibility criteria. No serious threats to validity were found. Both trials compared ultrasound-guided versus landmark-guided injections and were judged similar in clinical design. Low to moderate heterogeneity was observed: shoulder pain I²= 60%, function I²= 22%. A meta-analysis demonstrated greater improvement with ultrasound-guided injections at 6 weeks after injection in both pain (mean difference = 2.23 [95% CI: 1.27, 3.18]), as assessed with a 0 to 10 visual analogue scale, and shoulder function (standardised mean difference = 1.09 [95% CI: 0.61, 1.57]) as assessed with shoulder function scores. Although more adverse events (all mild) were reported with landmark-guided injections, the difference was not statistically significant (risk ratio = 0.20 [95% CI: 0.04, 1.13]).</p> <p>This review was only based on two moderate-sized trials. Blinding of patients was not performed in both trials, causing some risk of bias in outcome assessment since primary endpoints were wholly or partially patient-reported.</p> <p>Conclusion</p> <p>There is a paucity of RCTs on image-guided versus landmark-guided corticosteroid shoulder injections examining pain, function and adverse events. In this review, patients who underwent image-guided (ultrasound) injections had statistically significant greater improvement in shoulder pain and function at 6 weeks after injection. Image-guided (ultrasound) corticosteroid injections potentially offer a significantly greater clinical improvement over blind (landmark-guided) injections in adults with shoulder pain. However, this apparent benefit requires confirmation from further studies (adequately-powered and well-executed RCTs).</p

Perception of Stigma and Its Associated Factors Among Patients With Major Depressive Disorder: A Multicenter Survey From an Asian Population

Stigma of major depressive disorder (MDD) is an important public health problem. This study aimed to examine the level of perceived stigma and its associated factors in MDD patients in five Asian countries, including China, Korea, Malaysia, Singapore, and Thailand. A total of 547 outpatients with MDD were included from Asian countries. We used the stigma scale of the Explanatory Model Interview Catalogue (EMIC) to assess stigma. The Montgomery–Asberg Depression Rating Scale (MADRS), Symptoms Checklist 90-Revised (SCL-90-R), Fatigue Severity Scale (FSS), Sheehan Disability Scale (SDS), 36-Item Short-Form Health Survey (SF-36), and Multidimensional Scale of Perceived Social Support (MSPSS) were used to assess symptoms, clinical features, functional impairment, health status, and social support. The stigma scores of patients under 55 years old were significantly higher than those equal to or greater than 55 years old (P &lt; 0.001). The stigma scores exhibited significant negative correlation with age; MSPSS scores of family, friends, and others; and SF-36 subscale of mental health, but significant positive correlation with MADRS, FSS, SDS, and SCL-90-R subscale scores of depression, interpersonal sensitivity, obsession–compulsion, psychoticism, and somatization. Multivariate regression analysis revealed that age, SCL-90-R interpersonal sensitivity, obsession–compulsion, psychoticism, MSPSS scores of friends and others, and SF-36 of mental health were significantly associated with the level of perceived stigma. These findings suggest that MDD patients who are young, have a high degree of interpersonal sensitivity and psychoticism, have low health-related quality of life, and have low social support are the target population for stigma interventions in Asia

Germline Variation Controls the Architecture of Somatic Alterations in Tumors

Studies have suggested that somatic events in tumors can depend on an individual's constitutional genotype. We used squamous cell carcinomas (SCC) of the skin, which arise in high multiplicity in organ transplant recipients, as a model to compare the pattern of somatic alterations within and across individuals. Specifically, we performed array comparative genomic hybridization on 104 tumors from 25 unrelated individuals who each had three or more independently arisen SCCs and compared the profiles occurring within patients to profiles of tumors across a larger set of 135 patients. In general, chromosomal aberrations in SCCs were more similar within than across individuals (two-sided exact-test p-value ), consistent with the notion that the genetic background was affecting the pattern of somatic changes. To further test this possibility, we performed allele-specific imbalance studies using microsatellite markers mapping to 14 frequently aberrant regions of multiple independent tumors from 65 patients. We identified nine loci which show evidence of preferential allelic imbalance. One of these loci, 8q24, corresponded to a region in which multiple single nucleotide polymorphisms have been associated with increased cancer risk in genome-wide association studies (GWAS). We tested three implicated variants and identified one, rs13281615, with evidence of allele-specific imbalance (p-value = 0.012). The finding of an independently identified cancer susceptibility allele with allele-specific imbalance in a genomic region affected by recurrent DNA copy number changes suggest that it may also harbor risk alleles for SCC. Together these data provide strong evidence that the genetic background is a key driver of somatic events in cancer, opening an opportunity to expand this approach to identify cancer risk alleles

Diagnostic evaluation of pediatric myocarditis in the emergency department: A 10-year case series in the Asian population

10.1097/PEC.0b013e3182852f86Pediatric Emergency Care293346-351PECA