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Correlation of anti-CarP antibody and ACPA IgM, IgA, and IgG subclasses and RF-IgM with anti-CarP antibody and ACPA IgM in IgG double-positive RA. ELISAs were performed to detect anti-CarP antibody and ACPA isotypes and IgG subclasses in sera of 114 RA patients. Levels of anti-CarP antibodies and ACPAs were plotted against each other, each IgG subclass and isotype separately (A–F). As internal control anti-CarP IgM and ACPA IgM were plotted against RF-IgM (G, H). Spearman Rank tests were performed to investigate correlations. HC; healthy controls, RA; rheumatoid arthritis, ACPA; anti-citrullinated protein antibodies, anti-CarP antibody; anti-carbamylated protein antibody, RF; rheumatoid factor, AU/ml; arbitrary units per millilitre. (TIF 42723 kb

Additional file 2: of An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

Baseline characteristics of anti-CCP-2-negative RA patients. Baseline characteristics of anti-CCP-2-negative RA patients (n = 279) that are multiplex-negative or -positive. CCP cyclic citrullinated peptide, RA rheumatoid arthritis. (PDF 40 kb

Additional file 1: of An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting

Diagnosis of anti-CCP-2-negative non-RA patients. Diagnoses of anti-CCP-2-negative non-RA patients (n = 135) as assessed by an experienced rheumatologist after 1 year of follow-up stratified for multiplex positivity. CCP cyclic citrullinated peptide, RA rheumatoid arthritis. (PDF 14 kb

Additional file 1: of Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes

Figure S1. Agreement between previously determined antibody status and remeasurement by ELISA. Figure S2. Overlap of isotypes and antibodies at baseline. Figure S3. DAS over first year of treatment. Figure S4. Initial change in DAS and DFR outcomes within patients positive for individual antibodies. Figure S5. Association between baseline autoantibody profile and long-term sustained drug-free remission within patients that reached early remission and had outcome data available. (DOCX 1605 kb

Selected weight management interventions for military populations in the United States: a narrative report.

Overweight and obesity continues to be a significant public health burden in the US and particularly among military personnel. Although the US Department of Defense mandates standardized physical activity requirements for military members, incidence and prevalence of overweight and obesity among military personnel continue to increase. Each military department controls their own interventional strategies for physical fitness and weight control. However, unique challenges such as geographic transients, lack of central standardization and empirical efficacy data across military departments, and chronic stress associated with military service adversely affect program outcomes. This brief narrative report explores overweight and obesity interventions among military populations from 2006 to 2016 and includes programmatic reviews of eight overweight and obesity interventions: The Prevention of Obesity in Military Community; Health Eating, Activity, and Lifestyle Training Headquarters (H.E.A.L.T.H); ArmyMOVE!; L.I.F.E.; Look AHEAD; Nutrition-focused Wellness Coaching; Go for Green; and LE3AN. A majority of these interventions did not report significant weight loss 6 months post intervention, and did not mention a theoretical foundation within the interventions. Further research to examine the importance of theory-based programming is warranted to improve process and outcome objectives

Additional file 3: of Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study

Table presenting biological interaction analysis between HLA-DRB1 SE alleles and smoking with the number of autoantibodies in the NOAR and the EAC. (DOCX 17 kb