Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating Reagents

The syntheses of silica-supported oligomeric benzyl phosphates (Si-OBPn) and triazole phosphates (Si-OTPn) using ring-opening metathesis polymerization (ROMP) for use as efficient alkylating reagents is reported. Ease of synthesis and grafting onto the surface of norbornenyl-tagged (Nb-tagged) silica particles has been demonstrated for benzyl phosphate and triazole phosphate monomers. It is shown that these silica polymer hybrid reagents, Si-OBPn and Si-OTPn, can be used to carry out alkylation reactions with an array of different nucleophiles to afford the corresponding benzylated and (triazolyl)methylated products in good yield and high purity

Introducing an Adolescent Cognitive Maturity Index and Tracking Vulnerability in Emerging Adulthood

The transition from adolescence to young adulthood is a dynamic developmental period during which youth are striving for social independence while simultaneously undergoing maturation of cognitive control skills. Variation in growth trajectories of adolescent neurocognitive development has been hypothesized to contribute to adverse outcomes in the transition to adulthood, such as experiencing violence. However, there remains a lack of consensus on the normative trajectory of cognitive maturation. To address this problem, we derive a Cognitive Maturity Index (CMI), to estimate the difference between chronological and cognitive age predicted with latent factor estimates of inhibitory control, risky decision-making and emotional processing measured with standard neuropsychological instruments. Age prediction with latent factor estimates of cognitive skills approximated age within 10 months (Pearson's Correlation r=0.71). Males in advanced puberty displayed lower cognitive maturity relative to peers of the same age; manifesting as weaker inhibitory control, greater risk taking, desensitization to negative affect, and poor recognition of positive affect. Elevated risk for future violent outcomes was effected by delayed CMI and fully mediated by drive for achieving rewards, illustrating adolescent maturation as a risk traversal process into young adulthood. This work provides a foundation for deriving a more precise definition of cognitive maturity to aid empirical assessment of individual-specific developmental risk factors for adverse outcomes in emerging adulthood

Congenital anomalies associated with trisomy 18 or trisomy 13: a registry-based study in 16 european countries, 2000-2011

The aim of this study was to examine the prevalence of trisomies 18 and 13 in Europe and the prevalence of associated anomalies. Twenty-five population-based registries in 16 European countries provided data from 2000–2011. Cases included live births, fetal deaths (20+ weeks’ gestation), and terminations of pregnancy for fetal anomaly (TOPFAs). The prevalence of associated anomalies was reported in live births. The prevalence of trisomy 18 and trisomy 13 were 4.8 (95%CI: 4.7–5.0) and 1.9 (95%CI: 1.8–2.0) per 10,000 total births. Seventy three percent of cases with trisomy 18 or trisomy 13 resulted in a TOPFA. Amongst 468 live born babies with trisomy 18, 80% (76–83%) had a cardiac anomaly, 21% (17–25%) had a nervous system anomaly, 8% (6–11%) had esophageal atresia and 10% (8–13%) had an orofacial cleft. Amongst 240 Live born babies with trisomy 13, 57% (51–64%) had a cardiac anomaly, 39% (33–46%) had a nervous system anomaly, 30% (24–36%) had an eye anomaly, 44% (37–50%) had polydactyly and 45% (39–52%) had an orofacial cleft. For babies with trisomy 18 boys were less likely to have a cardiac anomaly compared with girls (OR?=?0.48 (0.30–0.77) and with trisomy 13 were less likely to have a nervous system anomaly [OR?=?0.46 (0.27–0.77)]. Babies with trisomy 18 or trisomy 13 do have a high proportion of associated anomalies with the distribution of anomalies being different in boys and girl