Green jobs from a small scale perspective : case studies from Malta

Sustainable energy policy and its potential to create green jobs in Malta, as seen from the point of view of Maltese civil society, provides the basis for a critical analysis of the development of environmental policies in Malta. The discussion is based on data emanating from a qualitative type of survey conducted among the key persons involved in the main organisations representing the Maltese civil society. What emerged from this data is that there is a high level of awareness among members of Maltese civil society about the need to create more green jobs and the formulation of an effective policy of sustainable development. Respondents stressed the challenges inherent in a small island sovereign state suffering from peripherality and insularity. However while acknowledging these constraints, respondents expressed a high degree of optimism about the implementation of an effective green policy. They maintain that part of the solution lies in devising innovative practices by means of which Maltese policy makers would exploit Malta’s geographical position and harness all possible material and human resources. However to achieve such a goal the process has be consultative and participative.European Parliamentpeer-reviewe

The Effects of Fatigue on Balance in Individuals with Parkinson\u27s Disease: Influence of Medication and Brain-Derived Neurotrophic Factor Genotype

Background and Purpose: The purpose was to investigate the effects of fatigue on balance in individuals with Parkinson’s disease (PD). Because falls in this population can have deleterious consequences, it is important to understand the influence of fatigue and PD medications on balance. Additionally, since brain-derived neurotrophic factor (BDNF) has been shown to be related to motor performance, we explored its role in balance fatigue. Participants: 27 individuals (age= 65.4±8.1; males= 14, females= 13) with neurologist-diagnosed PD. Of the 27, 13 were genotyped for BDNF as Val/Val, 11 as Val/Met, 2 as Met/Met, and one refused genotyping. Methods: Participants were tested twice, first on medication and second off medication, one week apart. On both days, participants completed the following tests before and after a fatiguing condition: mini-Balance Evaluation Systems Test (mini-BESTest), computerized dynamic posturography (sensory orientation and motor control), functional reach, and gait spatial-temporal parameters at preferred gait speed across an instrumented walking mat. To address the primary aim of the study, a 2 (condition: pre and post) X 2 (medication: on and off) factorial ANOVA was performed for each outcome variable in each of the following domains: 1. anticipatory postural response; 2. adaptive postural responses; 3. Dynamic balance; 4. sensory orientation; and, 5. gait characteristics. For the exploratory aim, independent t-tests were conducted to compare both pre- and post-fatigue states, and on and of medication states for all of the aforementioned balance domains. Results: There were no statistically significant interactions between time (pre and post) and medication (on and off) for anticipatory postural responses, adaptive postural responses, dynamic balance, sensory orientation, or gait characteristics (ps≥.187). Participants with BDNF Met alleles were not significantly different from Val/Val participants in balance or gait (ps≥.111) and response to a fatiguing condition (ps≥.070). Discussion: The results of this study suggest that fatigue does not have a detrimental effect on balance and gait in individuals with PD. Likewise, our results were also in line with other studies that suggest that PD medications are not effective for decreasing risk of falls due to postural instability. Lastly, these results also indicate that individuals with a BDNF Met allele are not at an increased fall risk after a fatiguing condition compared to those with the Val/Val genotype

Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol

The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking purH accumulate 5-amino-4-imidazole carboxamide ribotide (AICAR) and are unable to utilize glycerol as sole carbon and energy sources. The work described here demonstrates this lack of growth is due to inhibition of FBP by AICAR. Mutant alleles of fbp that restore growth on glycerol encode proteins resistant to inhibition by AICAR and the allosteric regulator AMP. This is the first report of biochemical characterization of substitutions causing AMP resistance in a bacterial FBP. Inhibition of FBP activity by AICAR occurs at physiologically relevant concentrations and may represent a form of regulation of gluconeogenic flux in Salmonella enterica

Octopi

The composition of the poem below was governed by one major and a couple minor lexical constraints. Can you discover the rules behind it

Screening of Irish Fruit and Vegetable Germplasm for Novel Anti-tumour and Pesticidal Compounds

Conference paperPhytochemicals are a rich source of novel therapeutic and insecticidal agents (McLaughlin and Chang, 1999). Considerable research effort has been directed at screening exotic and medicinal plants in the search for novel products. However, plants which have traditional food uses have been little explored. In addition the range, type and level of individual bioactive compounds can vary significantly between different species, different cultivars of the same species and different tissue types of the plant (Reilly, in press) Therefore, the objective of this study was to screen a range of fruits and vegetables which can be grown in Ireland for novel bioactive compounds for use in food production and as bio-pesticides.The author wishes to acknowledge the financial support from the Dublin Institute of Technology through an ABBEST fellowshi

Asymptotic Conditional Distribution of Exceedance Counts: Fragility Index with Different Margins

Let $\bm X=(X_1,...,X_d)$ be a random vector, whose components are not necessarily independent nor are they required to have identical distribution functions $F_1,...,F_d$. Denote by $N_s$ the number of exceedances among $X_1,...,X_d$ above a high threshold $s$. The fragility index, defined by $FI=\lim_{s\nearrow}E(N_s\mid N_s>0)$ if this limit exists, measures the asymptotic stability of the stochastic system $\bm X$ as the threshold increases. The system is called stable if $FI=1$ and fragile otherwise. In this paper we show that the asymptotic conditional distribution of exceedance counts (ACDEC) $p_k=\lim_{s\nearrow}P(N_s=k\mid N_s>0)$, $1\le k\le d$, exists, if the copula of $\bm X$ is in the domain of attraction of a multivariate extreme value distribution, and if $\lim_{s\nearrow}(1-F_i(s))/(1-F_\kappa(s))=\gamma_i\in[0,\infty)$ exists for $1\le i\le d$ and some $\kappa\in{1,...,d}$. This enables the computation of the FI corresponding to $\bm X$ and of the extended FI as well as of the asymptotic distribution of the exceedance cluster length also in that case, where the components of $\bm X$ are not identically distributed