2,823 research outputs found

    Forest Land Ownership Changes in Portugal

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    Speaking from the heart: a mathematical point of view

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    The mechanics associated with a living entity dictates its ability to survive or perish. Similarly, heart valve function relies on its mechanical properties and structural integrity. A compromise in these leads to diseased valve states. There are still many unknowns on the influence of dimensional changes in valve mechanics: to tackle this, we created a mathematical model describing the shape of a heart valve based upon clinical data. We then established a computational characterization associated with different valve configurations. Our model predicted different cases of function, associated with valve geometrical changes. Diseased configurations, yielded greater valve tissue stress in comparison with healthy ones, exhibiting greater damaging. Our model provides with adjustable geometric detail, useful to study customized cases by employing diverse patient data and generating a range of geometries for computational assessment. Such framework can aid in patient risk stratification by indicating which configurations are associated with unfavorable performance

    STRATEGI PUBLIC RELATIONS HOTEL LE MERIDIEN JAKARTA DALAM MELAKUKAN PROMOSI MELALUI MEDIA RELATIONS (STUDI KASUS : MEETING ROOM DI HOTEL LE MERIDIEN JAKARTA)

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    STRATEGI PUBLIC RELATIONS HOTEL LE MERIDIEN JAKARTA DALAM MELAKUKAN PROMOSI MELALUI MEDIA RELATIONS (STUDI KASUS : MEETING ROOM DI HOTEL LE MERIDIEN JAKARTA)

    Ixabepilone: a new treatment option for the management of taxane-resistant metastatic breast cancer

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    Ixabepilone (Ixempra®; Bristol-Myers Squibb) is a novel microtubule stabilizing agent recently approved for the treatment of metastatic breast cancer (MBC). This article focuses on considerations for ixabepilone administration and adverse event (AE) management, drawing from the biomedical literature indexed in PubMed, published abstracts from the American Society of Clinical Oncology annual meetings, and the manufacturer’s prescribing information for ixabepilone. Administered as monotherapy or in combination with capecitabine in clinical studies, ixabepilone demonstrated positive clinical response rates, prolonged progression-free survival, and a favorable safety profile in patients with MBC. Treatment-related AEs were predictable and manageable with dose modification, treatment interruption, and active management. As ixabepilone undergoes development in earlier lines of breast cancer therapy and in other solid tumors, oncology nurses will encounter more and more patients receiving ixabepilone therapy. If nurses are acquainted with the unique management strategies associated with ixabepilone treatment, as detailed herein, patients are more likely to receive the full benefit of therapy

    Structuring wicked problems in transdisciplinary research using the Social-Ecological Systems framework: an application to the montado system, Alentejo, Portugal

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    The aspiration to establish an effective dialogue between science and society has inspired some ground breaking examples of transdisciplinarity (TD). The core idea of TD is that different academic disciplines work jointly with practitioners to solve common problems. The first step of TD implies a contextualization that requires holistic and systemic thinking. To achieve this contextualization, we applied the Social–Ecological Systems (SES) framework with the aim of developing TD to deal with the recorded decline in area and tree density of the montado land-use system located in the Alentejo region, Portugal. The study was based both on a literature review and on the analysis of qualitative and quantitative data collected in a number of research projects on the montado. The results show that the lack of consensus regarding the system boundaries, the diverse range of mental models, and the disconnection between policymaking and system singularities are some of the conditions that can hinder TD efforts. The framework allowed the identification of knowledge gaps that limit the understanding of the problem complexity to be dealt with by a TD research process. There is a need to gain a better understanding of the governance system, and to characterize the different types of agro-silvo-pastoral combinations that can be designated as montado. With this detailed understanding, a tailored TD process can be designed. This work argues for the active use of the SES framework in TD in environmental management. Future research could focus on the framework’s utility in developing tools to assess and monitor transdisciplinary research

    Goods Booking System in WIJAYA Printing Company

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    In an age of globalization era is the all sophisticated and modern developments in science and technology are advancing rapidly. One of progress is the use of computers that have been widely used the entrepreneur as a tool for their business activities. Starting from mid-level businessmen to top-level businessmen. By using the computer all transactions will sale items stored neatly and orderly. System sales are currently running on the company often have difficulty in doing data collection of goods sold, and the calculated result of booking and reservation sales to make his report.For that need to be made at the company's computerized system, where the data will be easily processed into accurately and quickly. Checking goods obtained accurate results and the calculation of bookings will be stored properly

    Using Games and Smart Devices to Enhance Learning Geography and Music History

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    This paper presents the implementation of an educational game as a skill for Amazon’s software assistant Alexa. The main motivation behind this work comes from the fact that learning through games and smart devices is commonly better received by children. The application we discuss generates test questions by extracting and analyzing information from two major knowledge resources, DBpedia and Wikidata. The questions can be automatically adapted to the knowledge level of the player through Computer Adaptive Testing (CAT). Specifically designed for Alexa as a skill, with intents, slots and sample utterances, users can interact with our application through Alexa voice service or through any smartphone, allowing the game to be played from home, school or any other place with an Internet connection

    Time perception deficits in impulsivity disorders: A systematic review

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    This systematic review aims to identify evidences of distortions in time perception (TP) in people with impulsiv ity disorders or other conditions having impulsivity traits, namely traumatic brain injuries, certain personality disorders, addictive behavior disorders, and pathological gambling. Studies related to TP deficits and impulsivity disorders were retrieved from multiple literature databases, through predefined inclusion and exclusion criteria. From the 197 obtained documents, 47 were selected for analysis, and a final set of 15 studies was retrieved for this review. Regardless of some conflicting findings, the available results suggest that patients with orbitofrontal lesions produce and reproduce significantly less time and estimate time periods significantly longer than healthy subjects. Patients with borderline personality disorder show decreased time perception and patients with antisocial personality disorder seem to execute more premature responses during time estimation tasks. Stimulant dependent individuals also tend to overestimate the time intervals, and pathological gamblers demonstrate shorter time horizons than social gamblers. Taken together, the available data suggest that impulsive individuals tend to overestimate the passage of time and to execute more premature responses, producing and reproducing less time, but more research is necessary to increase the strength of the evidences on this issue. This systematic review updates evidences of distortions in TP in impulsivity, improving the understanding of the relations between these two variables.info:eu-repo/semantics/publishedVersio

    Neurophysiological evaluation of undergraduate portuguese young adults with regarding difficulties

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    Reading is a complex cognitive process that requires a simultaneous activation of different brain systems. Power EEG has been used to study activation patterns in dyslexic subjects, but so far, studies lack result’s coherence, including in adult dyslexic population. The Reading Age Test (TIL) is a screening assessment for dyslexia. TIL evaluates the processes of decoding and understanding. This test is adapted and validated to Portuguese language. Objective: To analyze neurophysiological differences in undergraduate adults with and without reading difficulties using power EEG, and compare the results with the ones found at younger ages. Methods: 209 college students were administered the TIL. EEG was collected with 26 students (21 within normal reading level; 5 with severe reading difficulties signalized with TIL). During the EEG, the participant was asked to follow a sequence of tasks, during a total of 15 minutes (Basal resting state, TIL, Pos-TIL resting state, Non-reading Task; final resting state). Subsequently, the Fourier Transform (FFT) algorithm was applied to the EEG signal from the Basal resting state and the two given tasks. Power spectra mean values of delta, theta and beta activity band, from electrodes F7, F8, T3, T4, T5 and T6 were analyzed performing Shapiro-Wilk tests. Results: No significant differences in mean variations (sig >0.05) were observed between groups during the analyzed periods, regarding electrode and brain activity band frequency. Conclusion: This study provided inconclusive results concerning power EEG different findings at the lower frontal gyrus region and temporal region, between subject with and without reading difficulties.info:eu-repo/semantics/publishedVersio
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