Superfluid Helium On-Orbit Transfer (SHOOT) operatons

The in-flight tests and the operational sequences of the Superfluid Helium On-Orbit Transfer (SHOOT) experiment are outlined. These tests include the transfer of superfluid helium at a variety of rates, the transfer into cold and warm receivers, the operation of an extravehicular activity coupling, and tests of a liquid acquisition device. A variety of different types of instrumentation will be required for these tests. These include pressure sensors and liquid flow meters that must operate in liquid helium, accurate thermometry, two types of quantity gauges, and liquid-vapor sensors

Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception

Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a d-specific ([D-Pen2,D-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), m-specific ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or k-specific\ud (U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated d- and k-opioid antinociception, but attenuated m-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex\ud provides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management

Amniotic-Fluid Ingestion Enhances the Central\ud Analgesic Effect of Morphine

Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine

The Analgesia-Enhancing Component of\ud Ingested Amniotic Fluid Does Not Affect\ud Nicotine-Induced Antinociception in\ud Naltrexone-Treated Rats

Ingestion of amniotic fluid and placenta by rats has been shown to enhance opioid-mediated antinociception but not affect the nonopioid-mediated antinociception produced by aspirin, suggesting spccificity for opioid-mediated processes. However, enhancement by the active substance(s) in amniotic fluid and placenta1 (POEF, for placental opioid-enhancing factor) of antinociception produced by other nonopioid mechanisms has yet to be examined. The present experiments tested whether ingestion of amniotic fluid enhances the antinociception produced by nicotine injection. In Experiment IA, Enhancement of morphine-mediated antinociception by ingestion of amniotic fluid was demonstrated in a hot-plate assay. In Experiment IB, rats pretreated with naltrexone were given an orogastric infusion of amniotic fluid or control (0.25 ml), then injected with nicotine (0, 0.075, 0.125, or 0.225 mg/kg subcutaneously), then tested for antinociception in a hot-plate assay. Amniotic fluid ingestion did not enhance the antinociception produced by various doses of nicotine. In Experiment 2, rats pretreated with naltrexone were given an orogastric infusion of amniotic fluid (0, 0.125,\ud 0.25, or 0.50 ml) and then injectcd with 0.125 mg/kg nicotine. None of the doses of amniotic fluid enhanced the nicotine-induced antinociception. The findings of these experiments lend support to our contention that the enhancement by POEF of antinociception is specific to opioid-mediated processes

Heat Switches for ADRs

Heat switches are key elements in the cyclic operation of Adiabatic Demagnetization Refrigerators (ADRs). Several of the types of heat switches that have been used for ADRs are described in this paper. Key elements in selection and design of these switches include not only ON/OFF switching ratio, but also method of actuation, size, weight, and structural soundness. Some of the trade-off are detailed in this paper

Using a Cold Radiometer to Measure Heat Loads and Survey Heat Leaks

We have developed an inexpensive cold radiometer for use in thermal/vacuum chambers to measure heat loads, characterize emissivity and specularity of surfaces and to survey areas to evaluate stray heat loads. We report here the results of two such tests for the James Webb Space Telescope to measure heat loads and effective emissivities of 2 major pieces of optical ground support equipment that will be used in upcoming thermal vacuum testing of the Telescope

Lack of analgesic efficacy in female rats of\ud the commonly recommended oral dose of\ud buprenorphine

Previous work in our laboratory showed that the recommended oral dose of buprenorphine (0.5 mg/kg) was not as effective\ud as the standard therapeutic subcutaneous dose for postoperative analgesia in male Long-Evans (hooded) and Sprague-Dawley (albino) rats. The aim of the current study was to extend this analysis to female rats. We measured the pain threshold in adult female rats in diestrus or proestrus before and 30 and 60 min after oral buprenorphine (0.5 mg/kg,), the standard subcutaneous dose of buprenorphine (0.05 mg/kg), or vehicle only (1 ml/kg each orally and subcutaneously). Female rats showed an increased pain threshold (analgesia) after subcutaneous buprenorphine but no change in pain threshold after either oral buprenorphine or vehicle only. Estrous cycle stage (proestrus versus diestrus) did not affect the analgesic effects of buprenorphine, but rats in proestrus showed significantly lower pain thresholds (less tolerance to pain) than did those in diestrus. These results show that the oral dose of buprenorphine recommended for postoperative analgesic care does not induce significant analgesia in female rats and therefore is not as effective as the standard subcutaneous dose

The Origins Space Telescope Cryo-Thermal Architecture

The Origins Space Telescope (OST) is studied as a future Mid- and Far-Infrared flagship-class observatory. OST will cover the wavelength range from 6 to 600 microns. To reach the sky background for 200-micron wavelengths temperatures of 4 degrees Kelvin or lower are required. To achieve this low temperature active cooling is required, along with passive shielding and passive radiation to deep space. Currently two concepts are being studied: Concept 1 with a 9-meter-diameter primary and a suite of 5 extremely capable instruments providing both imaging and spectroscopy over the entire wavelength range. Concept 2 is a more modest sized telescope with a collecting area equivalent to a 5-meter primary, fewer deployments and 3 or 4 instruments also covering the entire wavelength range for imaging and spectroscopy, although with somewhat reduced spectroscopic resolution, and somewhat slower mapping speed. This paper will describe OST Concept 2's cryogenic thermal architecture and thermal model results

Cooling the Origins Space Telescope

The NASA Astrophysics Division has commissioned 4 studies for consideration by the 2020 Decadal Survey to be the next flagship mission following WFIRST (Wide Field Infrared Survey Telescope). One of the four studies is the Origins Space Telescope (OST), which will cover wavelengths from 6 microns to 600 microns. To perform at the level of the zodiacal, galactic, and cosmic background, the telescope must be cooled to 4 degrees Kelvin. 4 degrees Kelvin multi-stage mechanical cryocoolers will be employed along with a multilayer sunshield/thermal shield to achieve this temperature with a manageable parasitic heat load. Current state-of-the-art cryocoolers can achieve close to 4 degrees Kelvin, providing about 50 megawatts of cooling at 4 degrees Kelvin with an input power of 500 watts. Multiple coolers at this power level will be used in parallel. These coolers also provide extra cooling power at intermediate temperature stages of 15-20 degrees Kelvin and 50-70 degrees Kelvin . This upper stage cooling will be used to limit the heat conducted to 4 degrees Kelvin . The multi-layer sunshield will limit the radiated thermal energy to the 4 degrees Kelvin volume. This paper will describe the architecture of the cryogenic system for OST along with preliminary thermal models

Cryogenic System for the Origins Space Telescope: Cooling a Large Space Telescope to 4K with Today's Technology

The Origins Space Telescope (OST) concept is one of four NASA Science Mission Directorate, Astrophysics Division, observatory concepts being studied for launch in the mid 2030's. OST's wavelength coverage will be from the midinfrared to the sub-millimeter, 6-600 microns. To enable observations at the zodiacal background limit the telescope must be cooled to about 4 K. Combined with the telescope size (currently the primary is 9 m in diameter) this appears to be a daunting task. However, simple calculations and thermal modeling have shown the cooling power required is met with several currently developed cryocoolers. Further, the telescope thermal architecture is greatly simplified, allowing simpler models, more thermal margin, and higher confidence in the final performance values than previous cold observatories. We will describe design principles to simplify modeling and verification. We will argue that the OST architecture and design principles lower its integration and test time and reduce its ultimate cost