Dissipative Dynamic Libraries (DDLs) and Dissipative Dynamic Combinatorial Chemistry (DDCC)

This Concept is focused on the key features of dissipative dynamic combinatorial chemistry (DDCC). DDCC deals with transient libraries of compounds, maintained out-of-equilibrium by the consumption of a fuel, whose composition changes upon the selection pressure of kinetic and/or thermodynamic processes. Concepts and definitions of kinetic and thermodynamic dissipative dynamic libraries ("KDDL" and "TDDL"), are introduced and illustrated by a number of actual cases, thus showing the consistency of the present approach. Such concepts and definitions can help establish a common language for this emerging field, which, in our view, has the potential to become highly relevant to supramolecular chemistry

Shallow subduction beneath Italy

This paper presents a velocity model of the Italian (central Mediterranean) lithosphere in unprecedented detail. The model is derived by inverting a set of 166,000 Pg and Pn seismic wave arrival times, restricted to the highest-quality data available. The tomographic images reveal the geometry of the subduction-collision system between the European, Adriatic, and Tyrrhenian plates, over a larger volume and with finer resolution than previous studies. We find two arcs of low-Vp anomalies running along the Alps and the Apennines, describing the collision zones of underthrusting continental lithospheres. Our results suggest that in the Apennines, a significant portion of the crust has been subducted below the mountain belt. From the velocity model we can also infer thermal softening of the crustal wedge above the subducting Adriatic plate. In the Tyrrhenian back-arc region, strong and extensive low-Vp anomalies depict upwelling asthenospheric material. The tomographic images also allow us to trace the boundary between the Adriatic and the Tyrrhenian plates at Moho depth, revealing some tears in the Adriatic-Ionian subducting lithosphere. The complex lithospheric structure described by this study is the result of a long evolution; the heterogeneities of continental margins, lithospheric underthrusting, and plate indentation have led to subduction variations, slab tears, and asthenospheric upwelling at the present day. The high-resolution model provided here greatly improves our understanding of the central Mediterranean’s structural puzzle. The results of this study can also shed light on the evolution of other regions experiencing both oceanic and continental subduction

Automatic seismic phase picking and consistent observation error assessment: application to the Italian seismicity

Accuracy of seismic phase observation and consistency of timing error assessment define the quality of seismic waves arrival times. High-quality and large data sets are prerequisites for seismic tomography to enhance the resolution of crustal and upper mantle structures. In this paper we present the application of an automated picking system to some 600 000 seismograms of local earthquakes routinely recorded and archived by the Italian national seismic network. The system defines an observation weighting scheme calibrated with a hand-picked data subset and mimics the picking by an expert seismologist. The strength of this automatic picking is that once it is tuned for observation quality assessment, consistency of arrival times is strongly improved and errors are independent of the amount of data to be picked. The application to the Italian local seismicity documents that it is possible to automatically compile a precise, homogeneous and large data set of local earthquake Pg and Pn arrivals with related polarities. We demonstrate that such a data set is suitable for high-precision earthquake location, focal mechanism determination and high-resolution seismic tomograph

Pain associated with COVID-19 vaccination is unrelated to skin biopsy abnormalities

Previous clinical observations raised the possibility that COVID-19 vaccination might trigger a small-fibre neuropathy.Objectives:In this uncontrolled observational study, we aimed to identify small fibre damage in patients complaining of generalized sensory symptoms and pain after COVID-19 vaccination.Methods:We collected clinical data, including a questionnaire for assessing autonomic symptoms (Composite Autonomic Symptom Score-31), and investigated quantitative sensory testing (QST) and skin biopsy in 15 prospectively enrolled patients with generalized sensory symptoms and pain after COVID-19 vaccination. Nine patients complaining of orthostatic intolerance also underwent cardiovascular autonomic tests.Results:We found that all patients experienced widespread pain, and most of them (11 of 15) had a fibromyalgia syndrome. All patients had normal skin biopsy findings, and in the 9 patients with orthostatic intolerance, cardiovascular autonomic tests showed normal findings. Nevertheless, 5 patients had cold and warm detection abnormalities at the QST investigation.Conclusions:In our study, most patients complaining of generalized sensory symptoms and pain after COVID-19 vaccination had clinical and diagnostic test findings compatible with a fibromyalgia syndrome. Although the abnormal QST findings we found in 5 patients might be compatible with a small-fibre neuropathy, they should be cautiously interpreted given the psychophysical characteristics of this diagnostic test. Further larger controlled studies are needed to define precisely the association between small fibre damage and COVID-19 vaccination

Data of safety in a single-center alemtuzumab treated population

Alemtuzumab is approved for highly active MS and, in Europe, can be employed after other disease-modifying treatments (DMTs) as an escalation approach or first therapeutic option. The occurrence of secondary autoimmune adverse events and infections differs depending on the employed approach. In the manuscript entitled “Alemtuzumab treatment of multiple sclerosis in real-world clinical practice: report from a single Italian center” by di Ioia M. and collaborators, efficacy and safety data of alemtuzumab were evaluated in a real-world MS population. The aim of the article is to describe in detail the unexpected serious adverse events which occurred in this cohort during and after the administration of the alemtuzumab treatment. Adverse events were observed in 45,7% of the patients. These events were ranked as severe in 23% of the patients. We reported, in particular, cases of autoimmune hemolytic anemia (AIHA), pancytopenia, viral hepatitis E and noninfectious meningo-encephalomyelitis

Intense terahertz pulses from SPARC-LAB coherent radiation source

The linac-based Terahertz source at the SPARC_LAB test facility is able to gene rate highly intense Terahertz broadband pulses via coherent transition radiation (CTR) from high brightness electron beams. The THz pulse duration is typically down to 100 fs RMS and can be tuned through the electron bunch duration and shaping. The measured stored energy in a single THz pulse has reached 40 μ J, which corresponds to a peak electric field of 1.6 MV/cm at the THz focus. Here we present the main features, in particular spatial and sp ectral distributions and energy characterizations of the SPARC_LAB THz source, which is very competitive for investigations in Condensed Matter, as well as a valid tool for electron beam longitudinal diagnostics

Human development and food (In)Security in Brazil: prioritisation of regions for policies targeting rice and bean production.

The objective of this study was to identify the main poverty areas in Brazil and check if they are important in growing rice and beans in order to be considered as priority areas for agricultural research and extension services

Automatic seismic phase picking and consistent observation error assessment: application to Italian seismicity

Accuracy of seismic phase observation and consistency of timing error assessment define the quality of seismic waves arrival times. High-quality and large data sets are prerequisites for seismic tomography to enhance the resolution of crustal and upper mantle structures. In this paperwe present the application of an automated picking system to some 600000 seismograms of local earthquakes routinely recorded and archived by the Italian national seismic network. The system defines an observation weighting scheme calibrated with a hand-picked data subset and mimics the picking by an expert seismologist. The strength of this automatic picking is that once it is tuned for observation quality assessment, consistency of arrival times is strongly improved and errors are independent of the amount of data to be picked. The application to the Italian local seismicity documents that it is possible to automatically compile a precise, homogeneous and large data set of local earthquake Pg and Pn arrivals with related polarities. We demonstrate that such a data set is suitable for high-precision earthquake location, focal mechanism determination and high-resolution seismic tomography

Time Programmable Locking/Unlocking of the Calix[4]arene Scaffold by Means of Chemical Fuels

In this work, we report that 2-cyano-2-phenylpropanoic acid and its p-Cl, p-CH3 and p-OCH3 derivatives can be used as chemical fuels to control the geometry of the calix[4]arene scaffold in its cone conformation. It is shown that, under the action of the fuel, the cone calix[4]arene platform assumes a “locked” shape with two opposite aromatic rings strongly convergent and the other two strongly divergent (“pinched cone” conformation). Only when the fuel is exhausted, the cone calix[4]arene scaffold returns to its resting, “unlocked” shape. Remarkably, the duration of the “locked” state can be controlled at will by varying the fuel structure or amount. A kinetic study of the process shows that the consume of the fuel is catalyzed by the “unlocked” calixarene that behaves as an autocatalyst for its own production. A mechanism is proposed for the reaction of fuel consumption