81 research outputs found
ICP-Mass-Spectrometry Ionic Profile of Whole Saliva in Patients with Untreated and Treated Periodontitis
Alpha-linolenic acid protects against cardiac injury and remodelling induced by beta-adrenergic overstimulation
Methods and protocols in peripheral nerve regeneration experimental research: part II-morphological techniques
Biomarker levels in gingival crevicular fluid of generalized aggressive periodontitis patients after non-surgical periodontal treatment
Sexual Violence and Alcohol Intake: A Population-Based Explorative Study in a Northwestern Italian Area
Background and Objectives: Sexual violence (SV) is a major global public health concern.
While socioeconomic factors and familial relationships have been widely reported to contribute to
SV, the role of alcohol consumption should not be ignored. Indeed, alcohol can impair cognition,
distort reality, increase aggression, and ease drug-facilitated sexual assault. This retrospective study
aims to explore the relationship between alcohol consumption and SV by examining the prevalence,
characteristics, and consequences of violence episodes. Materials and Methods: A total of 1481 women
accessed the Rape Centre “Centro Soccorso Violenza Sessuale” in Turin, Italy between 2008 and 2019,
with 223 reporting alcohol consumption before the assault. Results: The alcohol group had a younger
age profile, predominantly within the 18–25-year-old category. SV incidents involving alcohol
consumers were more likely to occur in public places or in someone else’s home, while the non-alcoholconsuming
group experienced more violence in their own homes. Acquaintances and unknown
individuals were primarily responsible, whereas partners were the most common perpetrators of
violence against non-alcohol-consuming women. Alcohol consumers sought medical attention sooner
after the assault and exhibited more symptoms and injuries, particularly of neurological origin.
Concurrent use of recreational drugs was higher among alcohol consumers. The logistic regression
analysis revealed higher odds of injury for Italian women and those in the 18–35 age groups after
consuming alcohol. Conclusions: This study contributes to the understanding of the relationship
between alcohol consumption and SV. The prevalence of alcohol-related sexual aggression is lower
compared to that shown in previous studies. Nationality, age, and assailant identity influence SV
dynamics. These findings can guide well-targeted interventions and prevention strategies to address
SV and inform communities facing similar challenges
ErbB2 receptor over-expression improves post-traumatic peripheral nerve regeneration in adult mice.
In a transgenic mice (BALB-neuT) over-expressing ErbB2 receptor, we investigated the adult mouse median nerve in physiological and pathological conditions. Results showed that, in physiological conditions, the grip function controlled by the median nerve in BALB-neuT mice was similar to wild-type (BALB/c). Stereological assessment of ErbB2-overexpressing intact nerves revealed no difference in number and size of myelinated fibers compared to wild-type mice. By contrast, after a nerve crush injury, the motor recovery was significantly faster in BALB-neuT compared to BALB/c mice. Moreover, stereological assessment revealed a significant higher number of regenerated myelinated fibers with a thinner axon and fiber diameter and myelin thickness in BALB-neuT mice. At day-2 post-injury, the level of the mRNAs coding for all the ErbB receptors and for the transmembrane (type III) Neuregulin 1 (NRG1) isoforms significantly decreased in both BALB/c and BALB-neuT mice, as shown by quantitative real time PCR. On the other hand, the level of the mRNAs coding for soluble NRG1 isoforms (type I/II, alpha and beta) increased at the same post-traumatic time point though, intriguingly, this response was significantly higher in BALB-neuT mice with respect to BALB/c mice. Altogether, these results suggest that constitutive ErbB2 receptor over-expression does not influence the physiological development of peripheral nerves, while it improve
Bioequivalence of Branded and Generic Oxaliplatin: From Preclinical Assessment to Clinical Incidence of Hypersensitivity Reactions
Preclinical pharmacokinetics comparison between resveratrol 2-hydroxypropyl-β-cyclodextrin complex and resveratrol suspension after oral administration
- …