Functional implications of minor mandibular asymmetry: clinical and digital research on a sample of healthy patients

OBJECTIVE.The aim of the study is to evaluate the influence that the mandibular asymmetry could have towards the other components of the Stomathognatic system and to further related structures from a functional point of view. MATERIALS and METHODS. A sample of 18 young asymmetric patients, in healthy status, was investigated with clinical evaluation and questionnaires and digital devices such as Electromiography, Stabilometry, T-scan and Formetric. Descriptive and quantitative statistical analysis were performed. RESULTS. ASIM electromyography index was significant only in a short percentage of the sample. Hypertonia of temporalis muscle in the same side of mandibular deviation and the cross-activation of the contralateral masseter were present. The data of the stabilometric platform showed that only 33% of patients had a load discrepancy between right and left side. All patients presented similar and limited postural anomalies during the Formetric examination. No significant results emerged from statistics . CONCLUSIONS. From the emerging data, mandibular asymmetry does not seem to be considered a potential risk factor for the development of functional anomalies both in the stomatognatic system and in the postural one. The only issue that should be considered is the condylar retrusion of the mandibular shortest side that is a possible destabilizing factor of the TMJ condyle-disc coordination

Functional implications of minor mandibular asymmetry: clinical and digital research on a sample of healthy patients

OBJECTIVE.The aim of the study is to evaluate the influence that the mandibular asymmetry could have towards the other components of the Stomathognatic system and to further related structures from a functional point of view. MATERIALS and METHODS. A sample of 18 young asymmetric patients, in healthy status, was investigated with clinical evaluation and questionnaires and digital devices such as Electromiography, Stabilometry, T-scan and Formetric. Descriptive and quantitative statistical analysis were performed. RESULTS. ASIM electromyography index was significant only in a short percentage of the sample. Hypertonia of temporalis muscle in the same side of mandibular deviation and the cross-activation of the contralateral masseter were present. The data of the stabilometric platform showed that only 33% of patients had a load discrepancy between right and left side. All patients presented similar and limited postural anomalies during the Formetric examination. No significant results emerged from statistics . CONCLUSIONS. From the emerging data, mandibular asymmetry does not seem to be considered a potential risk factor for the development of functional anomalies both in the stomatognatic system and in the postural one. The only issue that should be considered is the condylar retrusion of the mandibular shortest side that is a possible destabilizing factor of the TMJ condyle-disc coordination

Astrocomp: a web service for the use of high performance computers in Astrophysics

Astrocomp is a joint project, developed by the INAF-Astrophysical Observatory of Catania, University of Roma La Sapienza and Enea. The project has the goal of providing the scientific community of a web-based user-friendly interface which allows running parallel codes on a set of high-performance computing (HPC) resources, without any need for specific knowledge about parallel programming and Operating Systems commands. Astrocomp provides, also, computing time on a set of parallel computing systems, available to the authorized user. At present, the portal makes a few codes available, among which: FLY, a cosmological code for studying three-dimensional collisionless self-gravitating systems with periodic boundary conditions; ATD, a parallel tree-code for the simulation of the dynamics of boundary-free collisional and collisionless self-gravitating systems and MARA, a code for stellar light curves analysis. Other codes are going to be added to the portal.Comment: LaTeX with elsart.cls and harvard.sty (included). 7 pages. To be submitted to a specific journa

Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction

Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the excessive generation or accumulation of free radicals or their oxidation products. Free radicals formed during oxidative stress can initiate lipid peroxidation, oxidize proteins to inactive states and cause DNA strand breaks. Oxidative stress is a condition in which oxidant metabolites exert toxic effects because of their increased production or an altered cellular mechanism of protection. In the early phase of acute heart ischemia cytokines have the feature to be functional pleiotropy and redundancy, moreover, several cytokines exert similar and overlapping actions on the same cell type and one cytokine shows a wide range of biological effects on various cell types. Activation of cytokine cascades in the infarcted myocardium was established in numerous studies. In experimental models of myocardial infarction, induction and release of the pro-inflammatory cytokines like TNF-&alpha (Tumor Necrosis Factor &alpha), IL-1&beta (Interleukin- 1&beta) and IL-6 (Interleukin-6) and chemokines are steadily described. The current review examines the role of oxidative stress and pro-inflammatory cytokines response following acute myocardial infarction and explores the inflammatory mechanisms of cardiac injur

Basic fibroblast growth factor mediates carotid plaque instability through metalloproteinase-2 and –9 expression

OBJECTIVE(S): We hypothesized that basic fibroblast growth factor (bFGF) may exert a role in carotid plaque instability by regulating the expression of matrix metalloproteinases (MMP). METHODS: Plaques obtained from 40 consecutive patients undergoing carotid endarterectomy were preoperatively classified as soft or hard. Serum bFGF was pre- and postoperatively measured. The release of MMP-2 and MMP-9 in the blood serum, and the activity, production and expression in the carotid specimens was analyzed. Specific anti-bFGF inhibition tests were performed in vitro on human umbilical artery smooth muscle cells (HUASMC) to evaluate the role of bFGF in the activity, production and expression of MMP-2 and -9. RESULTS: Twenty-one (53%) patients had a soft carotid plaque and 19 (48%) a hard plaque. Preoperative bFGF serum levels were higher in patients with soft plaques [soft=34 (28-39) pg/mL and hard=20 (17-22) pg/mL-p<0.001] and postoperatively returned to normal values (when compared to 10 healthy volunteers). The serum levels of MMP-2 in patients' with soft plaques were higher than those in patients' with hard plaques [soft=1222 (1190-1252) ng/mL and hard=748 (656-793)ng/mL-p<0.0001]. MMP-9 serum values were 26 (22-29) ng/mL for soft plaques and 18 (15-21) ng/mL for hard plaques (p<0.0001). We found increased activity, production and expression of MMP-2 and -9 in soft plaques compared to hard plaques (p<0.001). In vitro inhibition tests on HUASMC showed the direct influence of bFGF on the activity, production and expression of MMP-2 and -9 (p<0.001). CONCLUSIONS: bFGF seems to exert a key role in carotid plaque instability regulating the activity, production and expression of MMP thus altering the physiologic homeostasis of the carotid plaque

Risk factors for adenocarcinoma in the surgically transposed colon not exposed to the fecal stream. Etiological considerations extrapolated to sporadic colon carcinoma in the general population

The aim of the study was to analyze the clinical characteristics and outcomes of patients with de novo secondary adenocarcinoma arising in the operatively transposed colon not exposed to the fecal stream

"Do the right thing" for whom? An experiment on ingroup favouritism, group assorting and moral suasion

In this paper we investigate the effect of moral suasion on ingroup favouritism. We report a well-powered, pre-registered, two-stage 2x2 mixed-design experiment. In the first stage, groups are formed on the basis of how participants answer to a set of questions, concerning non-morally relevant issues in one treatment (assorting on non-moral preferences), and morally relevant issues in another treatment (assorting on moral preferences). In the second stage, participants choose how to split a given amount of money between participants of their own group and participants of the other group, first in the baseline setting and then in a setting where they are told to do what they believe to be morally right (moral suasion). Our main results are: (i) in the baseline, participants tend to favour their own group to a greater extent when groups are assorted according to moral preferences, compared to when they are assorted according to non-moral preferences; (ii) the net effect of moral suasion is to decrease ingroup favouritism, but there is also a non-negligible proportion of participants for whom moral suasion increases ingroup favouritism; (iii) the effect of moral suasion is substantially stable across group assorting and four pre-registered individual characteristics (gender, political orientation, religiosity, pro-life vs pro-choice ethical convictions)

The effect of norm-based messages on reading and understanding COVID-19 pandemic response governmental rules

The new coronavirus disease (COVID-19) threatens the lives of millions of people around the world, making it the largest health threat in recent times. Billions of people around the world are asked to adhere to strict shelter-in-place rules, finalised to slow down the spread of the virus. Appeals and messages are being used by leaders and policy-makers to promote pandemic response. Given the stakes at play, it is thus important for social scientists to explore which messages are most effective in promoting pandemic response. In fact, some papers in the last month have explored the effect of several messages on people’s intentions to engage in pandemic response behaviour. In this paper, we make two contributions. First, we explore the effect of messages on people’s actual engagement, and not on intentions. Specifically, our dependent variables are the level of understanding of official COVID-19 pandemic response governmental informative panels, measured through comprehension questions, and the time spent on reading these rules. Second, we test a novel set of appeals built through the theory of norms. One message targets the personal norm (what people think is the right thing to do), one targets the descriptive norm (what people think others are doing), and one targets the injunctive norm (what people think others approve or disapprove of). Our experiment is conducted online with a representative (with respect to gender, age, and location) sample of Italians. Norms are made salient using a flier. We find that norm-based fliers had no effect on comprehension and on time spent on the panels. These results suggest that norm-based interventions through fliers have very little impact on people’s reading and understanding of COVID-19 pandemic response governmental rules

UVES observations of QSO 0000-2620: oxygen and zinc abundances in the Damped Ly-alpha galaxy at z_abs=3.3901

Observations of the QSO 0000-2620 with UVES spectrograph at the 8.2m ESO KUEYEN telescope are used for abundance analysis of the damped Ly-alpha system at z_{abs}=3.3901. Several Oxygen lines are identified in the Ly_alpha forest and a measure for the oxygen abundance is obtained at [O/H]=-1.85 +/- 0.1 by means of the unsaturated OI 925 A and OI 950 A lines. This represents the most accurate O measurement in a damped Ly_alpha galaxy so far. We have also detected ZnII 2026 A and CrII 2056, 2062 A redshifted at about 8900 A and found abundances [Zn/H] = -2.07 +/- 0.1 and [Cr/H]=-1.99 +/- 0.1. Furthermore, previous measurements of Fe, Si, Ni and N have been refined yielding [Fe/H]=-2.04 +/- 0.1, [Si/H]=-1.90 +/- 0.1, [Ni/H]=-2.27 +/- 0.1, and [N/H]=-2.68 +/- 0.1. The abundance of the non-refractory element zinc is the lowest among the damped Ly-alpha systems showing that the associated intervening galaxy is indeed in the early stages of its chemical evolution. The fact that the Zn abundance is identical to that of the refractory elements Fe and Cr suggests that dust grains have not formed yet. In this Damped Ly-alpha system the observed [O,S,Si/Zn,Fe,Cr] ratios, in whatever combination are taken, are close to solar (i.e 0.1-0.2 dex) and do not show the [alpha-element/Fe] enhancement observed in Milky Way stars of comparable metallicity. The observed behavior supports a galaxy evolution model characterized by either episodic or low star formation rate rather than a Milky-Way-type evolutionary model.Comment: Accepted by Ap