Food-borne Lactiplantibacillus plantarum protect normal intestinal cells against inflammation by modulating reactive oxygen species and IL-23/IL-17 axis

Food-associated Lactiplantibacillus plantarum (Lpb. plantarum) strains, previously classified as Lactobacillus plantarum, are a promising strategy to face intestinal inflammatory diseases. Our study was aimed at clarifying the protective role of food-borne Lpb. plantarum against inflammatory damage by testing the scavenging microbial ability both in selected strains and in co-incubation with normal mucosa intestinal cells (NCM460). Here, we show that Lpb. plantarum endure high levels of induced oxidative stress through partially neutralizing reactive oxygen species (ROS), whereas they elicit their production when co-cultured with NCM460. Moreover, pre-treatment with food-borne Lpb. plantarum significantly reduce pro-inflammatory cytokines IL-17F and IL-23 levels in inflamed NCM460 cells. Our results suggest that food-vehicled Lpb. plantarum strains might reduce inflammatory response in intestinal cells by directly modulating local ROS production and by triggering the IL-23/IL-17 axis with future perspectives on health benefits in the gut derived by the consumption of functional foods enriched with selected strains

Climate fluctuations and human impact during the late Holocene in a multi-proxy marine record from the Gulf of Gaeta (Tyrrhenian Sea, central Italy)

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Antegrade selective cerebral perfusion in patients with "bovine aortic arch": is it easier?

[No abstract available

A comprehensive interpretative model of slow slip events on Mt. Etna’s eastern flank

Starting off from a review of previous literature on kinematic models of the unstable eastern flank of Mt. Etna, we propose a new model. The model is based on our analysis of a large quantity of multidisciplinary data deriving from an extensive and diverse network of INGV monitoring devices deployed along the slopes of the volcano. Our analysis had a twofold objective: first, investigating the origin of the recently observed slow-slip events on the eastern flank of Mt. Etna; and second, defining a general kinematic model for the instability of this area of the volcano. To this end, we investigated the 2008–2013 period using data collected from different geochemical, geodetic, and seismic networks, integrated with the tectonic and geologic features of the volcano and including the volcanic activity during the observation period. The complex correlations between the large quantities of multidisciplinary data have given us the opportunity to infer, as outlined in this work, that the fluids of volcanic origin and their interrelationship with aquifers, tectonic and morphological features play a dominant role in the large scale instability of the eastern flank of Mt. Etna. Furthermore, we suggest that changes in the strain distribution due to volcanic inflation/deflation cycles are closely connected to changes in shallow depth fluid circulation. Finally, we propose a general framework for both the short and long term modeling of the large flank displacements observed.Published635–6581IT. Reti di monitoraggio e OsservazioniJCR Journalrestricte

The ATLAS MDT remote calibration centers

The precision chambers of the ATLAS Muon Spectrometer are built with Monitored Drift Tubes (MDT). The requirement of high accuracy and low systematic error, to achieve a transverse momentum resolution of 10% at 1 TeV, can only be accomplished if the calibrations are known with an accuracy of 20 μm. The relation between the drift path and the measured time (the socalled r-t relation) depends on many parameters (temperature T, hit rate, gas composition, thresholds,...) subject to time variations. The r-t relation has to be measured from the data without the use of an external detector, using the autocalibration technique. This method relies on an iterative procedure applied to the same data sample, starting from a preliminary set of constants. The required precision can be achieved using a large (few thousand) number of non-parallel tracks crossing a region, called calibration region, i.e. the region of the MDT chamber sharing the same r-t relation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/85421/1/jpconf10_219_022028.pd

Determining the electron-phonon coupling in superconducting cuprates by resonant inelastic x-ray scattering: Methods and results on Nd1+xBa2-xCu3O7-δ

The coupling between lattice vibration quanta and valence electrons can induce charge-density modulations and decisively influence the transport properties of materials, e.g., leading to conventional superconductivity. In high-critical-temperature superconductors, where electronic correlation is the main actor, the actual role of electron-phonon coupling (EPC) is being intensely debated theoretically and investigated experimentally. We present an in-depth study of how the EPC strength can be obtained directly from resonant inelastic x-ray scattering (RIXS) data through the theoretical approach derived by Ament et\ua0al. [Europhys. Lett. 95, 27008 (2011)]. The role of the model parameters (e.g., phonon energy ω0, intermediate state lifetime 1/Γ, EPC matrix element M, and detuning energy Ω) is thoroughly analyzed, providing general relations among them that can be used to make quantitative estimates of the dimensionless EPC g=(M/ω0)2 without detailed microscopic modeling. We then apply these methods to very high-resolution Cu L3-edge RIXS spectra of three Nd1+xBa2−xCu3O7−δ films. For the insulating antiferromagnetic parent compound, the value of M as a function of the in-plane momentum transfer is obtained for Cu-O bond-stretching (breathing) and bond-bending (buckling) phonon branches. For the underdoped and the nearly optimally doped samples, the effects of Coulomb screening and of charge-density-wave correlations on M are assessed. In light of the anticipated further improvements of the RIXS experimental resolution, this work provides a solid framework for an exhaustive investigation of the EPC in cuprates and other quantum materials