Why reintroducing military conscription in Europe would be counterproductive

The reintroduction of military conscription has frequently been proposed as a way to instil national values in younger citizens. These arguments have gained added significance in Europe following Russia’s invasion of Ukraine. Drawing on new research, Vincenzo Bove, Riccardo Di Leo and Marco Giani argue that many of the proposed benefits of conscription are difficult to identify empirically. Indeed, far from fostering cohesion among citizens, conscription appears to be linked to a decline in institutional trust

A study of working fluids for heat driven ejector refrigeration using lumped parameter models

This paper studies the influence of working fluids over the performance of heat driven ejector refrigeration systems performance by using a lumped parameter model. The model used has been selected after a comparison of different models with a set of experimental data available in the literature. The effect of generator, evaporator and condenser temperature over the entrainment ratio and the COP has been investigated for different working fluids in the typical operating conditions of low grade energy sources. The results show a growth in performance (the entrainment ratio and the COP) with a rise in the generator and evaporator temperature and a decrease in the condenser temperature. The working fluids have a great impact on the ejector performance and each refrigerant has its own range of operating conditions. R134a is found to be suitable for low generator temperature (70-100 degrees C), whereas the hydrocarbons R600 is suitable for medium generator temperatures (100-130 degrees C) and R601 for high generator temperatures (130-180 degrees C). (C) 2015 Elsevier Ltd and IIR. All rights reserved

Bacterial Zinc Metalloenzyme Inhibitors: Recent Advances and Future Perspectives

Human deaths caused by Gram-negative bacteria keep rising due to the multidrug resistance (MDR) phenomenon. Therefore, it is a priority to develop novel antibiotics with different mechanisms of action. Several bacterial zinc metalloenzymes are becoming attractive targets since they do not show any similarities with the human endogenous zinc-metalloproteinases. In the last decades, there has been an increasing interest from both industry and academia in developing new inhibitors against those enzymes involved in lipid A biosynthesis, and bacteria nutrition and sporulation, e.g., UDP-[3-O-(R)-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase (LpxC), thermolysin (TLN), and pseudolysin (PLN). Nevertheless, targeting these bacterial enzymes is harder than expected and the lack of good clinical candidates suggests that more effort is needed. This review gives an overview of bacterial zinc metalloenzyme inhibitors that have been synthesized so far, highlighting the structural features essential for inhibitory activity and the structure-activity relationships. Our discussion may stimulate and help further studies on bacterial zinc metalloenzyme inhibitors as possible novel antibacterial drugs

The motherhood penalties : insights from women in UK academia

We use an original survey of academic women in the UK to investigate different dimensions of the motherhood penalty. Being a mother has no effect on salaries, but still slows down career progression even in such a high-skilled sector. Motherhood has an ambivalent impact on women’s perception of their working environment: improving satisfaction, but reducing perception of salary fairness relative to men. Our paper also explores how different policies can mitigate the motherhood penalties. We find that more generous maternity provisions are associated with higher salary, potentially because generosity reduces the crowding out of research activity. Better availability of childcare and an even distribution of responsibilities within the household correlate positively with earnings. Our findings also highlight the importance of a supportive work environment for mothers’ career and well-being at the workplace. Taken together, these findings suggest the necessity of a multi-faceted policy response to the motherhood penalties

Motherhood in academia : a novel dataset with an application to maternity leave uptake

Legislation over the past two decades enhanced the availability and quantity of statutory maternity leave in the United Kingdom. In high-skilled sectors, many employers top up this maternity leave in an effort to retain and develop the careers of women. As leave provision became more generous, debates emerged as to the role, if any, these enhanced benefits have in retaining women in high status occupation and facilitating their career growth. Further, individual situations and employment status may prevent women from taking advantage of enhanced benefits. This paper presents findings from a comprehensive survey of thousands of women in the UK Higher Education sector and documents how the lives of academic mothers changed over the past quarter century. Contract status and the partner’s participation in parenting has significant effects on the types of maternity leave taken. We reflect on these findings and discuss future research in the area of labour market equity and productivity the availability of this comprehensive quantitative survey of academic women can facilitate

Ground currents in a photovoltaic power plant: Theoretical approach and experimental tests

Arrays of photovoltaic (PV) modules, mounted on metallic structures, always create stray capacitances between active conductors and ground. Thus, leakage currents flowing in these ground capacitances are formed. If the number of PV modules array is high, these currents can reach some amperes. Noticeable leakage currents can cause several problems related to the proper operation of electrical installation and appliances and to the safety of people. In this work, the problem of the ground currents in PV arrays is firstly studied from a theoretical point of view. Suitable equivalent circuits are presented. Then, the set-up and the results of a field measurement for the estimation of the leakage currents in an operating PV power plant are reported

Motherhood in academia : a novel dataset of UK academic women with an application to maternity leave uptake

Motherhood is widely believed to be an important factor slowing down the career progression of women. We present a novel database that combines an original survey of women and mothers working in the UK Higher Education sector with data on the occupational maternity benefits offered by academic employers. This allows users to track, at the individual level, child‐bearing experiences and employment histories simultaneously. We describe several aspects of mothers' experiences in academia and how those evolve over the years. We also conduct an empirical analysis of the determinants of maternity leave uptake, showing that women's employment status and family arrangements significantly impact the types of maternity leave – paid or unpaid – taken

Motherhood in academia: A novel dataset of <scp>UK</scp> academic women with an application to maternity leave uptake

AbstractMotherhood is widely believed to be an important factor slowing down the career progression of women. We present a novel database that combines an original survey of women and mothers working in the UK Higher Education sector with data on the occupational maternity benefits offered by academic employers. This allows users to track, at the individual level, child‐bearing experiences and employment histories simultaneously. We describe several aspects of mothers' experiences in academia and how those evolve over the years. We also conduct an empirical analysis of the determinants of maternity leave uptake, showing that women's employment status and family arrangements significantly impact the types of maternity leave – paid or unpaid – taken.</jats:p

Reduction of mdx mouse muscle degeneration by low-intensity endurance exercise: a proteomic analysis in quadriceps muscle of exercised versus sedentary mdx mice

In our recent study was shown a significant recovery of damaged skeletal muscle of mice with x-linked muscular dystrophy (mdx) following low-intensity endurance exercise, probably by reducing the degeneration of dystrophic muscle. Consequently, in the present work we aimed to identify proteins involved in the observed reduction of degenerating fibers. To this end, we used proteomic analysis to evaluate changes in the protein profile of quadriceps dystrophic muscles of exercised versus sedentary mdx mice. Four protein spots were found to be significantly changed and were identified as three isoforms of Carbonic anhydrase 3 (CA3) and superoxide dismutase [Cu-Zn] (SODC). Protein levels of CA3 isoforms were significantly up-regulated in quadriceps of sedentary mdx mice and were completely restored to wild type mice values, both sedentary and exercised, in quadriceps of exercised mdx mice. Protein levels of SODC were down-regulated in quadriceps of sedentary mdx mice and were significantly restored to wild type mice values, both sedentary and exercised, in quadriceps of exercised mdx mice. Western blot data were in agreement with those obtained using proteomic analysis and revealed the presence of one more CA3 isoform that was significantly changed. Based on data found in the present study, it seems that low-intensity endurance exercise may in part contribute to reduce cell degeneration process in mdx muscles, by counteracting oxidative stress

Identification of a Novel p53 Modulator Endowed with Antitumoural and Antibacterial Activity through a Scaffold Repurposing Approach

Intracellular pathogens, such as Chlamydia trachomatis, have been recently shown to induce degradation of p53 during infection, thus impairing the protective response of the host cells. Therefore, p53 reactivation by disruption of the p53-MDM2 complex could reduce infection and restore pro-apoptotic effect of p53. Here, we report the identification of a novel MDM2 inhibitor with potential antitumoural and antibacterial activity able to reactivate p53. A virtual screening was performed on an in-house chemical library, previously synthesised for other targets, and led to the identification of a hit compound with a benzo[a]dihydrocarbazole structure, RM37. This compound induced p53 up-regulation in U343MG glioblastoma cells by blocking MDM2-p53 interaction and reduced tumour cell growth. NMR studies confirmed its ability to dissociate the MDM2-p53 complex. Notably, RM37 reduced Chlamydia infection in HeLa cells in a concentration-dependent manner and ameliorated the inflammatory status associated with infection