Changes in total choline concentration in the breast of healthy fertile young women in relation to menstrual cycle or use of oral contraceptives: a 3-T 1H-MRS study

BACKGROUND: To evaluate changes in total choline (tCho) absolute concentration ([tCho]) in the breast of healthy fertile women in relation to menstrual cycle (MC) or use of oral contraceptives (OC). METHODS: After institutional review board approval, we prospectively evaluated 40 healthy fertile volunteers: 20 with physiological MC, aged 28 ± 3 years (mean ± standard deviation; nOC group); 20 using OC, aged 26 ± 3 years (OC group). Hormonal assays and water-suppressed single-voxel 3-T proton magnetic resonance spectroscopy (1H-MRS) were performed on MC days 7, 14, and 21 in the nOC group and only on MC day 14 in the OC group. [tCho] was measured versus an external phantom. Mann-Whitney U test and Spearman coefficient were used; data are given as median and interquartile interval. RESULTS: All spectra had good quality. In the nOC group, [tCho] (mM) did not change significantly during MC: 0.8 (0.3-2.4) on day 7, 0.9 (0.4-1.2) on day 14, and 0.4 (0.2-0.8) on day 21 (p = 0.963). In the OC group, [tCho] was 0.7 (0.2-1.7) mM. The between-groups difference was not significant on all days (p ≥ 0.411). All hormones except prolactin changed during MC (p ≤ 0.024). In the OC group, [tCho] showed a borderline correlation with estradiol (r = 0.458, p = 0.056), but no correlation with other hormones (p ≥ 0.128). In the nOC group, [tCho] negatively correlated with prolactin (r = -0.587, p = 0.006) on day 7; positive correlation was found with estradiol on day 14 (r = 0.679, p = 0.001). CONCLUSIONS: A tCho peak can be detected in the normal mammary gland using 3-T 1H-MRS. The [tCho] in healthy volunteers was 0.4-0.9 mM, constant over the MC and independent of OC use

Environmental improvement and conservation of useful pastures for wild herbivores in a Regional Park on the Apennines mountains

In order to investigate some effects of the environmental management with faunistic purpose on pastures located on the Apennines mountains, in open areas subjected to bracken fern (Pteridium aqulinum) infestation, samples of vegetation were taken for three years on an open area in the Regional Park of "Laghi di Suviana e Brasimone" (BO). Experimental samples, taken before and after the agronomical works, showed the effects of the pasture improvement on botanical composition, richness and biodiversity. The agronomical pasture management produced a considerable decrease in bracken density and an increase on biodiversity, and the final average value of the Pastoral Value index was quadruplicate. These results confirmed the effectiveness of the actions carried out and the importance of maintaining a continuous programme of pasture management through annual clearing of vegetation

The next step in sustainable dining: the restaurant food waste map for the management of food waste

In recent years, out-of-home food waste is growing exponentially and therefore represents an important focus of attention, albeit little research has been done on this instance. A few researchers have developed frameworks to better explain wasteful behaviors away from home, however a comprehensive interpretation of the phenomenon giving indications for maps/guidelines for the foodservice managers has not been carried out. In this paper, as a result of a thematic literature review, the Restaurant Food Waste Map (RFWM) was designed to describe the phases in which the food waste phenomenon occurs, and to identify mitigation activities of food waste generation processes. The proposed map is aimed to describe three phases in which the food waste phenomenon occurs: (1) kitchen food preparation, (2) food service, and (3) clients' consumption. Moreover, the present map highlights the approaches that restaurants could take into consideration to better manage the food waste: (1) prevention, (2) reduction, and (3) reuse/redistribution of food waste. These approaches set out guidance on the preferred methods of dealing with food waste so as to minimize its impact on the environment and society. The present study provides literature knowledge about food waste management at the restaurant level, and highlights some practical implications. Further studies could explore and analyze out-of-home waste from both the client and business perspective according to the proposed RFWM, to target specific attitudes and behavioral changes, and to quantify the impacts of the suggested changes. Reducing food waste is a key sustainability challenge for the food service industry. Despite the significance of this issue, a comprehensive interpretation of the phenomenon giving indications for maps/guidelines for the foodservice managers has received limited attention in the literature. As a result of a thematic literature review, the RFWM was designed to describe the phases in which the food waste phenomenon occurs, and to identify mitigation activities of food waste generation processes with practice-driven initiatives an organized map has been developed. The proposed map is aimed to describe three phases in which the food waste phenomenon occurs: (1) kitchen food preparation, (2) food service, and (3) clients' consumption. Moreover, the present map highlights the approaches that restaurants could take into consideration to reduce food waste: (1) prevention, (2) reduction, and (3) reuse/redistribution of food waste. The present study provides literature knowledge about food waste management at the restaurant level, and highlights some practical implications. Further studies could explore and analyze out-of-home waste from both the client and business perspective according to the proposed RFWM, to target specific attitudes and behavioral changes, and to quantify the impacts of the suggested changes. The concepts discussed here could help practitioners to become more aware of the factors that drive the adoption of food waste management practices

Sustainability reporting practices. An explorative analysis of luxury fashion brands

PurposeThe purpose of this research is to identify the sustainable practices of luxury fashion brands through their communications via official reporting documents to classify practices used for communicating sustainability performance.Design/methodology/approachThis research uses the qualitative content analysis of Global Reporting Initiative (GRI)-oriented sustainability reports to examine the sustainable practices of 31 companies within the top 100 global luxury brands.FindingsThe authors classify the sample into four clusters: sustainability driven, sustainability newcomers, sustainability potential and sustainability passive. Results indicate that companies in this sector are focused on the issue of sustainability even though there is a remarkable fragmentation in terms of practices.Originality/valueThe study contributes to a better understanding of sustainability reporting activities and approaches in the fashion luxury industry by describing best practices and the effect of sustainability in corporate communications

Feeding evaluation of spontaneous species used by wild ungulates

Abandonment of traditional agricultural practices can produce remarkable effects on land use and on the vegetal composition of marginal areas. This is particularly true in the once grazed zones in the mountain environments, that are now affected by encroachment of shrubby vegetation. The conservation of these open areas and the preservation of a correct ratio pasture/wood are of extremely importance for wild animals. In this note we describe the effectiveness of agronomical intervention carried out to enhance pasture quality in a protected area of central Italy. Data collection concerned botanical composition, floristic richness and biodiversity of vegetation, before and after the intervention efforts. Moreover, data on utilization of single species were collected in order to evaluate the real consumption of each plant species by wild animals. Results confirmed the efficiency of the improvement of the studied area in terms of botanical composition and of pastoral value and they provided useful indications about the actual utilization of non forage plants by wild ungulates

Allergenius, an expert system for the interpretation of allergen microarray results

BACKGROUND: An in vitro procedure based on a microarray containing many different allergen components has recently been introduced for use in allergy diagnosis. Recombinant and highly purified allergens belonging to different allergenic sources (inhalants, food, latex and hymenoptera) are present in the array. These components can either be genuine or cross-reactive, resistant or susceptible to heat and low pH, and innocuous or potentially dangerous. A large number of complex and heterogeneous relationships among these components has emerged, such that sometimes these interactions cannot be effectively managed by the allergist. In the 1960s, specialized languages and environments were developed to support the replacement of human experts with dedicated decision-making information systems. Currently, expert systems (ES) are advanced informatics tools that are widely used in medicine, engineering, finance and trading. METHODS: We developed an ES, named Allergenius ®, to support the interpretation of allergy tests based on microarray technology (ImmunoCAP ISAC ®). The ES was implemented using Flex, a LPA Win-Prolog shell. Rules representing the knowledge base (KB) were derived from the literature and specialized databases. The input data included the patient’s ID and disease(s), the results of either a skin prick test or specific IgE assays and ISAC results. The output was a medical report. RESULTS: The ES was first validated using artificial and real life cases and passed all in silico validations. Then, the opinions of allergists with experience in molecular diagnostics were compared with the ES reports. The Allergenius reports included all of the allergists’ opinions and considerations, as well as any additional information. CONCLUSIONS: Allergenius is a trustable ES dedicated to molecular tests for allergy. In the present version, it provides a powerful method to understand ISAC results and to obtain a comprehensive interpretation of the patient’s IgE profiling

Screening and diagnostic breast MRI: how do they impact surgical treatment? Insights from the MIPA study

To report mastectomy and reoperation rates in women who had breast MRI for screening (S-MRI subgroup) or diagnostic (D-MRI subgroup) purposes, using multivariable analysis for investigating the role of MRI referral/non-referral and other covariates in driving surgical outcomes. The MIPA observational study enrolled women aged 18–80 years with newly diagnosed breast cancer destined to have surgery as the primary treatment, in 27 centres worldwide. Mastectomy and reoperation rates were compared using non-parametric tests and multivariable analysis

A Phenomenological Approach to Medication Adherence in Elderly Patients: A Qualitative Study

Background: Patient adherence to drug treatment is crucial to the success of any prescribed therapy, especially in chronic conditions. The present phenomenological qualitative study aims to explore the elderly experience in managing their medication therapy and their perception of medication adherence. Methods: Based on Husserl's perspective, a qualitative descriptive study was conducted utilizing the phenomenological approach, specifically Interpretative Phenomenological Analysis (IPA). The data analysis followed Giorgi's phenomenological approach and the inductive content analysis method. Approval for the study was obtained from the relevant Ethics Committee. Results: Themes emerged when participants described experiences about their own adherence to therapy. The following general theme emerged from the interviews and the phenomenological analysis: Generating awareness: taking therapy saves your life. It was followed by three other themes: (1) Drug therapy awareness; (2) Drug therapy in daily life; and (3) Drug therapy as a life partner. Conclusions: Elderly patients undergoing polypharmacological treatment emphasize the key factors for improving medication adherence, highlighting the influence of individual, motivational, and relational aspects. They express a strong desire for information and value the support of family doctors and nurses in managing therapy. Patient interviews indicate general support among elderly patients for using mobile health in pharmacological treatment, recognizing its potential and limitations