Identification of Showers with Cores Outside the ARGO-YBJ Detector

In any EAS array, the rejection of events with shower cores outside the detector boundaries is of great importance. A large difference between the true and the reconstructed shower core positions may lead to a systematic miscalculation of some shower characteristics. Moreover, an accurate determination of the shower core position for selected internal events is important to reconstruct the primary direction using conical fits to the shower front, improving the detector angular resolution, or to performe an efficient gamma/hadron discrimination. In this paper we present a procedure able to identify and reject showers with cores outside the ARGO-YBJ carpet boundaries. A comparison of the results for gamma and proton induced showers is reported.Comment: 4 pages, to be published in the Proceedings of the 28th International Cosmic Ray Conference (Tsukuba, Japan 2003

Expected sensitivity of ARGO-YBJ to detect point gamma-ray sources

ARGO-YBJ is a full coverage air shower detector currently under construction at the Yangbajing Laboratory (4300 m a.s.l., Tibet, China). First data obtained with a subset of the apparatus will be available in summer 2003 while the full detector operation is expected in 2005. One of the main aims of ARGO-YBJ is the observation of gamma-ray sources, at an energy threshold of a few hundreds GeV. In this paper we present the expected sensitivity to detect point gamma ray sources, with particular attention to the Crab Nebula. According to our simulations a Crab-like signal could be detected in one year of operation with a statistical significance of 10 standard deviations, without any gamma/hadron discrimination.Comment: 4 pages, 2 Postscript figure

Atmospheric Thermodynamic Profiling through the Use of a Micro-Pulse Raman Lidar System: Introducing the Compact Raman Lidar MARCO

It was for a long time believed that lidar systems based on the use of high-repetition micro-pulse lasers could be effectively used to only stimulate atmospheric elastic backscatter echoes, and thus were only exploited in elastic backscatter lidar systems. Their application to stimulate rotational and roto-vibrational Raman echoes, and consequently, their exploitation in atmospheric thermodynamic profiling, was considered not feasible based on the technical specifications possessed by these laser sources until a few years ago. However, recent technological advances in the design and development of micro-pulse lasers, presently achieving high UV average powers (1–5 W) and small divergences (0.3–0.5 mrad), in combination with the use of large aperture telescopes (0.3–0.4 m diameter primary mirrors), allow one to presently develop micro-pulse laser-based Raman lidars capable of measuring the vertical profiles of atmospheric thermodynamic parameters, namely water vapor and temperature, both in the daytime and night-time. This paper is aimed at demonstrating the feasibility of these measurements and at illustrating and discussing the high achievable performance level, with a specific focus on water vapor profile measurements. The technical solutions identified in the design of the lidar system and their technological implementation within the experimental setup of the lidar prototype are also carefully illustrated and discussed

Characterization of the planetary boundary layer height and structure by Raman lidar: comparison of different approaches

Abstract. The planetary boundary layer (PBL) includes the portion of the atmosphere which is directly influenced by the presence of the earth's surface. Aerosol particles trapped within the PBL can be used as tracers to study the boundary-layer vertical structure and time variability. As a result of this, elastic backscatter signals collected by lidar systems can be used to determine the height and the internal structure of the PBL. The present analysis considers three different methods to estimate the PBL height. The first method is based on the determination of the first-order derivative of the logarithm of the range-corrected elastic lidar signals. Estimates of the PBL height for specific case studies obtained through this approach are compared with simultaneous estimates from the potential temperature profiles measured by radiosondes launched simultaneously to lidar operation. Additional estimates of the boundary layer height are based on the determination of the first-order derivative of the range-corrected rotational Raman lidar signals. This latter approach results to be successfully applicable also in the afternoon–evening decaying phase of the PBL, when the effectiveness of the approach based on the elastic lidar signals may be compromised or altered by the presence of the residual layer. Results from these different approaches are compared and discussed in the paper, with a specific focus on selected case studies collected by the University of Basilicata Raman lidar system BASIL during the Convective and Orographically-induced Precipitation Study (COPS)

In silico analysis of TTR gene (coding and non-coding regions, and interactive network) and its implications in transthyretin-related amyloidosis.

Introduction: Transthyretin (TTR)-related amyloidosis is a life-threatening disease. Currently, several questions about the pathogenic mechanisms of TTR-related amyloidosis remain unanswered. Methods: We have investigated various TTR-related issues using different in silico approaches. Results: Using an amino acid similarity-based analysis, we have indicated the most relevant TTR secondary structures in determining mutation impact. Our amyloidogenic propensity analysis of TTR missense substitutions has highlighted a similar pattern for wild-type and mutated TTR amino b acid sequences. However, some mutations present differences with respect to the general distribution. We have identified non-coding variants in cis-regulatory elements of the TTR gene, and our analysis on V122I-related haplotypes has indicated differences in non-coding regulatory variants, suggesting differences among V122I carriers. The analysis of methylation status indicated CpG sites that may affect TTR expression. Finally, our interactive network analysis revealed functional partners of TTR that may play a modifier role in the pathogenesis of TTR-related amyloidosis. Discussion and conclusion: Our data provided new insights into the pathogenesis of TTR-related amyloidosis that, if they were to be confirmed through experimental investigations, could significantly improve our understanding of the disease

Fixture-abutment connection surface and micro-gap measurements by 3D micro-tomographic technique analysis

X-ray micro-tomography (micro-CT) is a miniaturized form of conventional computed axial tomography (CAT) able to investigate small radio-opaque objects at a-few-microns high resolution, in a non-destructive, non-invasive, and tri-dimensional way. Compared to traditional optical and electron microscopy techniques, which provide two-dimensional images, this innovative investigation technology enables a sample tri-dimensional analysis without cutting, coating or exposing the object to any particular chemical treatment. X-ray micro-tomography matches ideal 3D microscopy features: the possibility of investigating an object in natural conditions and without any preparation or alteration; non-invasive, non-destructive, and sufficiently magnified 3D reconstruction; reliable measurement of numeric data of the internal structure (morphology, structure and ultra-structure). Hence, this technique has multi-fold applications in a wide range of fields, not only in medical and odontostomatologic areas, but also in biomedical engineering, materials science, biology, electronics, geology, archaeology, oil industry, and semi-conductors industry. This study shows possible applications of micro-CT in dental implantology to analyze 3D micro-features of dental implant to abutment interface. Indeed, implant-abutment misfit is known to increase mechanical stress on connection structures and surrounding bone tissue. This condition may cause not only screw preload loss or screw fracture, but also biological issues in peri-implant tissues

Assessment of Trends and Uncertainties in the Atmospheric Boundary Layer Height Estimated Using Radiosounding Observations over Europe

Trends in atmospheric boundary layer height may represent an indication of climate changes. The related modified interaction between the surface and free atmosphere affects both thermodynamics variables and dilution of chemical constituents. Boundary layer is also a major player in various feedback mechanisms of interest for climate models. This paper investigates trends in the nocturnal and convective boundary layer height at mid-latitudes in Europe using radiosounding profiles from the Integrated Global Radiosounding Archive (IGRA). Atmospheric data from the European Centre for Medium-Range Weather Forecasts (ECMWF) ReAnalysis v5 (ERA5) and from the GCOS Reference Upper-Air Network (GRUAN) Lindenberg station are used as intercomparison datasets for the study of structural and parametric uncertainties in the trend analysis. Trends are calculated after the removal of the lag-1 autocorrelation term for each time series. The study confirms the large differences reported in literature between the boundary layer height estimates obtained with the two different algorithms used for IGRA and ERA5 data: ERA5 shows a density distribution with median values of 350 m and 1150 m for the night and the daytime data, respectively, while the corresponding IGRA median values are of 1150 m and 1750 m. An overall good agreement between the estimated trends is found for nighttime data, while daytime ERA5 boundary layer height estimates over Europe are characterized by a lower spatial homogeneity than IGRA. Parametric uncertainties due to missing data in both the time and space domain are also investigated: the former is not exceeding 1.5 m, while the latter are within 10 m during night and 17 m during the day. Recommendations on dataset filtering based on time series completeness are provided. Finally, the comparison between the Lindenberg data as processed at high-resolution by GRUAN and as provided to IGRA at a lower resolution, shows the significant impact of using high-resolution data in the determination of the boundary layer height, with differences from about 200 m to 450 m for both night and day, as well as a large deviation in the estimated trend

Metabolic Effects of the Intracellular Regulation of Thyroid Hormone: Old Players, New Concepts

Thyroid hormones (THs) are key determinants of cellular metabolism and regulate a variety of pathways that are involved in the metabolism of carbohydrates, lipids and proteins in several target tissues. Notably, hyperthyroidism induces a hyper-metabolic state characterized by increased resting energy expenditure, reduced cholesterol levels, increased lipolysis and gluconeogenesis followed by weight loss, whereas hypothyroidism induces a hypo-metabolic state characterized by reduced energy expenditure, increased cholesterol levels, reduced lipolysis and gluconeogenesis followed by weight gain. Thyroid hormone is also a key regulator of mitochondria respiration and biogenesis. Besides mirroring systemic TH concentrations, the intracellular availability of TH is potently regulated in target cells by a mechanism of activation/inactivation catalyzed by three seleno-proteins: type 1 and type 2 iodothyronine deiodinase (D1 and D2) that convert the biologically inactive precursor thyroxine T4 into T3, and type 3 iodothyronine deiodinase (D3) that inactivates TH action. Thus, the pleiotropic effects of TH can fluctuate among tissues and strictly depend on the cell-autonomous action of the deiodinases. Here we review the mechanisms of TH action that mediate metabolic regulation. This review traces the critical impact of peripheral regulation of TH by the deiodinases on the pathways that regulate energy metabolism and the balance among energy intake, expenditure and storage in specific target tissues

Role of surface microgeometries on electron escape probability and secondary electron yield of metal surfaces

The influence of microgeometries on the Secondary Electron Yield (SEY) of surfaces is investigated. Laser written structures of different aspect ratio (height to width) on a copper surface tuned the SEY of the surface and reduced its value to less than unity. The aspect ratio of microstructures was methodically controlled by varying the laser parameters. The results obtained corroborate a recent theoretical model of SEY reduction as a function of the aspect ratio of microstructures. Nanostructures - which are formed inside the microstructures during the interaction with the laser beam - provided further reduction in SEY comparable to that obtained in the simulation of structures which were coated with an absorptive layer suppressing secondary electron emission