Hearts of Darkness: the inside out probing of black holes

Classical black holes shield us from the singularities that inevitably appear in general relativity. Singularity regularization being one of the main landmarks for a successful theory of quantum gravity, quantum black holes are not obliged to hide their inner core from the outside world. Notwithstanding the aforesaid, it is often implicitly assumed that quantum gravity effects must remain confined to black hole interiors. In this essay, we argue in the opposite direction, discussing theoretical evidence for the existence of strong correlations between the physics inside and outside nonsingular black holes. We conclude that astronomical tests of the surroundings of black holes can provide invaluable information about their so-far unexplored interiors

Opening the Pandora's box at the core of black holes

We present a geometric classification of all spherically symmetric spacetimes that could result from singularity regularization, using a kinematic construction that is both exhaustive and oblivious to the dynamics of the fields involved. Due to the minimal geometric assumptions underlying it, this classification encompasses virtually all modified gravity theories, and any theory of quantum gravity in which an effective description in terms of an effective metric is available. The first noteworthy conclusion of our analysis is that the number of independent classes of geometries that can be constructed is remarkably limited, with no more than a handful of qualitatively different possibilities. But our most remarkable result is that this catalogue of possibilities clearly demonstrates that the degree of internal consistency and the strength of deviations with respect to general relativity are strongly, and positively, correlated. Hence, either quantum fluctuations of spacetime come to the rescue and solve these internal consistency issues, or singularity regularization will percolate to macroscopic (near-horizon) scales, radically changing our understanding of black holes and opening new opportunities to test quantum gravity

Nod2 Deficiency in mice is Associated with Microbiota Variation Favouring the Expansion of mucosal CD4+ LAP+ Regulatory Cells

Nucleotide-binding Oligomerization Domain-2 (NOD2) mutations are associated with an increased risk to develop Crohn's Disease. In previous studies, we have shown that Nod2-/- mice manifest increased proportion of Lamina Propria (LP) CD4+ LAP+ Foxp3- regulatory cells, when compared with Nod2+/+ mice, while CD4+ Foxp3 + regulatory cells were not affected. Here, we investigated the Nod2 gut microbiota, by 16S rRNA pyrosequencing, at steady state and after TNBS-colitis induction in mice reared separately or in cohousing, correlating the microbial profiles with LP regulatory T cells proportion and tissue cytokines content. We found that enrichment of Rikenella and Alistipes (Rikenellaceae) in Nod2-/- mice at 8 weeks of age reared separately was associated with increased proportion of CD4+ LAP+ Foxp3- cells and less severe TNBS-colitis. In co-housed mice the acquisition of Rickenellaceae by Nod2+/+ mice was associated with increased CD4+ LAP+ Foxp3- proportion and less severe colitis. Severe colitis was associated with enrichment of gram-negative pathobionts (Escherichia and Enterococcus), while less severe colitis with protective bacteria (Barnesiella, Odoribacter and Clostridium IV). Environmental factors acting on genetic background with different outcomes according to their impact on microbiota, predispose in different ways to inflammation. These results open a new scenario for therapeutic attempt to re-establish eubiosis in Inflammatory Bowel Disease patients with NOD2 polymorphisms

Hyperthermic Perfusion 16 Years After its First Clinical Applications

It is known that above-normal temperatures (42°-42.5°C) provoke selective damage to neoplastic cells. We used heated circulating blood as a method for heat transfer on patients with limb tumors. From October 1964 to December 1979, we treated a total of 198 patients with hyperthermic perfusion for melanoma of the limbs (91), osteosarcoma (57), and soft tissue sarcoma (50). For melanoma patients, the five-year survival rate, excluding Stage IV, was 60%. For patients with soft tissue sarcoma, the five-year survival rates were 53% and 56% for hyperthermic perfusion and hyperthermic antiblastic perfusion. respectively. For 29 patients with osteosarcoma, hyperthermic perfusion was combined with systematic amputation ofthe limb for a 60% survival rate over a five-year period. Newer studies with osteosarcoma patients involve a multistep treatment that saves the tumor-bearing limb without reducing survival rates. Our 16-year clinical trial demonstrates that hyperthermia is effective in curing some tumors of the limbs, especially osteosarcoma and melanoma. We believe that perfusion remains the most reliable heat transfer method for loco-regional treatment and perhaps even for whole-body treatment for limb tumors

A dendrochronological analysis of Pinus pinea L. on the Italian mid-Tyrrhenian coast

In order to assess the response of the radial growth of Pinus pinea L. to climatic variability in Central Italy, dendrochronological and dendroclimatological analyses were carried out on five different populations scattered along the Tyrrhenian coasts of the peninsula. The aim of this study is to contribute to the understanding of the ecological demands of this species, particularly in the study area. For each site total ring, early-, and late-wood width chronologies were developed. Multidimensional analyses were performed for the three tree-ring datasets in order to analyze the relations between sites chronologies. Both Principal Component Analyses and hierarchical classifications highlighted an important difference of one site in respect to the other, probably due to site characteristics. Correlation functions were performed to infer the main climatic factors controlling the radial growth of the species. For a comparative study, we limited our attention to the common interval 1926-2003 (78 years) in which the response of the tree-ring chronologies to climate at both local and regional scale was investigated. Positive moisture balance in the late spring-summer period of the year of growth is the climatic driver of P. pinea radial growth in the study area. Moreover, this study shows how low summer temperatures strongly favor the radial growth of the species.Fil: Piraino, Sergio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto Argentino de Investigaciones de Zonas Aridas; ArgentinaFil: Camiz, Sergio. Universita degli studi di Roma "Sapienza". Dipartimento di Matematica; ItaliaFil: Di Filippo, Alfredo. Universita Degli Studi Della Tuscia. DendrologyLab; ItaliaFil: Piovesan, Gianluca. Universita Degli Studi Della Tuscia. DendrologyLab; ItaliaFil: Spada, Francesco. Universita degli studi di Roma "Sapienza". Dipartimento de biología ambientale; Itali

Variable parameters for a single exponential model of photovoltaic modules in crystalline-silicon

The correct approximation of parallel resistance (Rp) and series resistance (Rs) poses a major challenge for the single diode model of the photovoltaic module (PV). The bottleneck behind the limited accuracy of the model is the static estimation of resistive parameters. This means that Rp and Rs, once estimated, usually remain constant for the entire operating range of the same weather condition, as well as for other conditions. Another contributing factor is the availability of only standard test condition (STC) data in the manufacturer’s datasheet. This paper proposes a single-diode model with dynamic relations of Rp and Rs. The relations not only vary the resistive parameters for constant/distinct weather conditions but also provide a non-iterative solution. Initially, appropriate software is used to extract the data of current-voltage (I-V) curves from the manufacturer’s datasheet. By using these raw data and simple statistical concepts, the relations for Rp and Rs are designed. Finally, it is proved through root mean square error (RMSE) analysis that the proposed model holds a one-tenth advantage over numerous recently proposed models. Simultaneously, it is low complex, iteration-free (0 to voltage in maximum power point Vmpp range), and requires less computation time to trace the I-V curve

On the Inner Horizon Instability of Non-Singular Black Holes

Regular black holes represent a conservative model in which the classical singularity is replaced by a non-singular core without necessarily modifying the spacetime outside the trapping horizon. Given the possible lack of phenomenological signatures, it is crucial to study the consistency of the model. In this short work, we review the physical mechanism leading to the instability of the central core, arguing that that non-perturbative backreation is non-negligible and must be taken into account to provide a meaningful description of physical black holes

Inner horizon instability and the unstable cores of regular black holes

Regular black holes with nonsingular cores have been considered in several approaches to quantum gravity, and as agnostic frameworks to address the singularity problem and Hawking’s information paradox. While in a recent work we argued that the inner core is destabilized by linear perturbations, opposite claims were raised that regular black holes have in fact stable cores. To reconcile these arguments, we discuss a generalization of the geometrical framework, originally applied to Reissner-Nordtsröm black holes by Ori, and show that regular black holes have an exponentially growing Misner-Sharp mass at the inner horizon. This result can be taken as an indication that stable nonsingular black hole spacetimes are not the definitive endpoint of a quantum gravity regularization mechanism, and that nonperturbative backreation effects must be taken into account in order to provide a consistent description of the quantum-gravitational endpoint of gravitational stellar collapse