152 research outputs found
Ex vivo HR-MAS Magnetic Resonance Spectroscopy of human gastric adenocarcinomas: A comparison with healthy gastric mucosa
The present study reports the characteristics of the biochemical profile of human gastric adenocarcinoma in comparison with that of healthy gastric mucosa, using ex vivo HR-MAS Magnetic Resonance Spectroscopy. Healthy human mucosa is mainly characterized by the presence of small metabolites (more than 50 identified) and macromolecules, whereas the adenocarcinoma spectra are dominated by the presence of signals due to triglycerides, whose content on the contrary is very low in healthy gastric mucosa. The use of spin-echo experiments enable us to detect some metabolites in the unhealthy tissues and to determine their variation with respect to the healthy ones. We have observed that the Cho:ChoCC ratio changes from 20:80 in the healthy tissues to 80:20 in the neoplastic gastric mucosa
Comparison of Data with Multiple Degrees of Freedom Utilizing the Feature Selective Validation (FSV) Method
This research is the product of a collaboration between:
1. Harbin Institute of Technology, China
2. De Montfort University, UK
3. University of L'Aquila, Italy
â© 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other worksThe feature selective validation method has been
shown to provide results that are in broad agreement with the
visual assessment of a group of engineers for line, 1-D, data. An
implementation using 2-D Fourier transforms and derivatives have
been available for some years, but verification of the performance
has been difficult to obtain. Further, that approach does not naturally
scale well for 3-D and higher degrees of freedom, particularly
if there are sizable differences in the number of points in the different
directions. This paper describes an approach based on repeated
1-D FSV analyses that overcomes those challenges. The ability of
the 2-D case to mirror user perceptions is demonstrated using the
LIVE database. Its extension to n-dimensions is also described and
includes a suggestion for weighting the algorithm based on the
number of data points in a given âdirection.
Down-sampled and Under-sampled Data sets in Feature Selective Validation (FSV)
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.Feature Selective Validation (FSV) is a heuristic method for quantifying the (dis)similarity of two data sets. The computational burden of obtaining the FSV values might be unnecessarily high if data sets with large numbers of points are used. While this may not be an important issue per se it is an important issue for future developments in FSV such as real-time processing or where multi-dimensional FSV is needed. Coupled with the issue of data set size, is the issue of data sets having âmissingâ values. This may come about because of a practical difficulty or because of noise or other confounding factors making some data points unreliable. These issues relate to the question âwhat is the effect on FSV quantification of reducing or removing data points from a comparison â i.e. down- or under-sampling data?â This paper uses three strategies to achieve this from known data sets. This paper demonstrates, through a representative sample of 16 pairs of data sets, that FSV is robust to changes providing a minimum data set size of approximately 200 points is maintained. It is robust also for up to approximately 10% âmissingâ data, providing this does not result in a continuous region of missed data
Castel di Sangro-Scontrone field camp â structural and applied geomorphology
The Geomorphological Field Camp 2014 in the Castel di Sangro-Scontrone area is the result of geological and geomorphological teaching field work activities carried out in Central Italy by a group of 23 students attending the Structural Geomorphology and Applied Geomorphology courses (Master's Degree in Geological Science and Technology of the UniversitĂ degli Studi âG. d'Annunzioâ Chieti-Pescara, Italy, Department of Engineering and Geology). The Field Camp 2014 was organized in May 2014, following regular classes held during the fall term. General activities for the field camp were developed over four main stages: (1) preliminary analysis of the regional geological and geomorphological setting of the area; (2) preliminary activities for the analysis of the local area (orography, hydrography and photogeology investigations, and geographical information system processing); (3) field work, focused on the analysis of a specific issue concerning structural geomorphology or applied geomorphology (e.g. landscape evolution, river channel change, landslide distribution, and flood hazard); and (4) post-field work production of the map. Finally, the fundamental role of field work in the analysis of landscape and in land management was outlined: indeed, the overall field camp enhanced the crucial role of field-based learning for young geomorphologists in order to acquire a strong sensitivity to geomorphological processes and landscape evolution
The contribution of Real Madridâs first five European Cups to the emergence of a common football space
Real Madrid won the first five editions of the European Champion Clubsâ Cup (now formally known as the UEFA Champions League, and to which we will refer hereon as the European Cup) between 1956 and 1960, contributing decisively to the competitionâs consolidation. The tournamentâs history started towards the end of 1954, when a journalist of the French sports daily LâĂquipe, Gabriel Hanot, published an article arguing the need to organise a competition that could bring together the champions of every European league. However, this was not an original proposal. Thirty years before Hanotâs article proposals for such a football competition were circulated among the gameâs ruling elite. Unfortunately, at that time the lack of a good transport infrastructure to travel through Europe discouraged the proposers which, instead, turned their attention to regional supranational competitions, such as the Mitropa Cup or the Latin Cup. The first five editions of the European Cup witnessed as many victories of Real Madrid, thus forging an indissoluble bond between the competition and the Spanish club. These five European titles did not only cement the supremacy of Real Madrid on the pitch as a great football team, but they also contributed to the consolidation of the European Cup itself in the publicâs imaginary. We also argue that given the expectations raised by Real Madridâs triumphs across Europe those matches might have contributed as well to the emergence of a European football space. Since 1955 Real Madrid occupied an ever increasing space in the press across Europe. Real Madrid was then considered as the best expression of modernity in football. This chapter aims to analyse the meaning of these five European Cup titles for the emergence and definition of a nascent European football space. We, of course, also question whether such a common space can be found. The chapter explores in depth the reasons behind Real Madridâs enthusiasm with the new European competition. We also examine the social impact that Real Madridâs hegemony in the European Cup had in the context of Spainâs international isolation during General Francoâs dictatorship (1939-1975). In order to achieve the above mentioned objectives, the chapter relies on thematic analysis of selected publications in the Spanish and British press during those years. Moreover, we have also relied on a review of academic literature on the role of Real Madrid during the Franco dictatorship years, mainly the 1950s and 60s. This chapter is part of wider on-going research. In this research we examine the content of two Spanish dailies (ABC and Marca) and three British newspapers (The Guardian, The Times and the Daily Mirror). We searched these newspapers for content related to Real Madrid on specific dates: The semifinal games (two legs) and the final of each one of the five years where Real Madrid won the European Cup. We searched for content the day of each match, the day before and two days after each one of the matches. This chapter is a presentation of the findings obtained through thematic analysis of the data obtained through those searches
Early Detection of t(8;21) Chromosomal Translocations During Treatment of PML-RARA Positive Acute Promyelocytic Leukemia: A Case Study
Here we describe a female patient who developed acute promyelocytic leukemia (APL) characterized by t(l5;17) translocation at diagnosis. The patient began treatment with all-trans retinoic acid (ATRA) + chemotherapy. During follow up, the patient was found to be negative for the t(15;17) transcript after 3 months of therapy which remained undetectable, thereafter. However, the emergence of a small clone with a t(8;21) abnormality was observed in the bone marrow and peripheral blood (PB) cells between 3 and 18 months following treatment initiation. The abnormal translocation observed in PB cells obtained at 3 months was detected after the second cycle of consolidation therapy and reappeared at 15 months during maintenance treatment, a period without ATRA. Although based on a single case, we conclude that genetic screening of multiple translocations in AML patients should be requested to allow early identification of other emerging clones during therapy that may manifest clinically following treatment
Long-term management of GERD in the elderly with pantoprazole
The prevalence of gastroesophageal reflux disease (GERD) increases with age and elderly are more likely to develop severe disease. Older patients often complain of less severe or frequent heartburn than younger patients and they may present with atypical symptoms such as dysphagia, weight loss, or extraesophageal symptoms. Proton pump inhibitors (PPIs) are central in the management of GERD and are unchallenged with regards to their efficacy. They are considered safe and more effective than histamine receptor antagonists for healing esophagitis and for preventing its recurrence using a long term maintenance treatment. PPI have minimal side effects and few slight drug interactions and are considered safe for long term treatment. Pantoprazole is significantly effective both for acute and long-term treatment with excellent control of relapse and symptoms. It is well tolerated even for long-term therapy and its tolerability is optimal. Pantoprazole shows to have minimal interactions with other drugs because of a lower affinity for cytocrome P450 than older PPIs. Although the majority of elderly has concomitant illnesses and receive other drugs, this does not adversely effect the efficacy of pantoprazole because of its pharmacokinetics, which are independent of patient age. Clinical practice suggests that a low dose maintenance of PPIs should be used in older patients with GERD
Liberal governmentality in Spain: bodies, minds, and the medical construction of the âoutsider,â 1870â1910
This paper traces the fragility of the subject in the period extending from the aftermath of the Sexenio through to the early twentieth century. In particular, two case studies are focused upon: the question of gender âdevianceâ and the figure of the genius, in order to understand how medicine participated in the construction of âoutsiderâ identities within the context of the emerging liberal order. How did liberal rationales exclude or curtail certain wayward expressions of identity and subjectivity? What consequences did the marking of âexcessiveâ figures or outsiders have for notions of inclusiveness and citizenship within the late-nineteenth-century liberal order? By concentrating primarily on medical texts and journals published during the period, this study builds on existing research to tease out answers to these questions
Escleroterapia versus somatostatina na hemorragia digestiva alta por ruptura de varizes esofĂĄgicas
ICAROS (Italian survey on CardiAc RehabilitatiOn and Secondary prevention after cardiac revascularization): Temporary report of the first prospective, longitudinal registry of the cardiac rehabilitation network GICR/IACPR
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