In-flight calibrations of IBIS/PICsIT

PICsIT (Pixellated Imaging CaeSium Iodide Telescope) is the high energy detector of the IBIS telescope on-board the INTEGRAL satellite. It consists of 4096 independent detection units, ~0.7 cm^2 in cross-section, operating in the energy range between 175 keV and 10 MeV. The intrinsically low signal to noise ratio in the gamma-ray astronomy domain implies very long observations, lasting 10^5-10^6 s. Moreover, the image formation principle on which PICsIT works is that of coded imaging in which the entire detection plane contributes to each decoded sky pixel. For these two main reasons, the monitoring, and possible correction, of the spatial and temporal non-uniformity of pixel performances, expecially in terms of gain and energy resolution, is of paramount importance. The IBIS on-board 22Na calibration source allows the calibration of each pixel at an accuracy of <0.5% by integrating the data from a few revolutions at constant temperature. The two calibration lines, at 511 and 1275 keV, allow also the measurement and monitoring of the PICsIT energy resolution which proves to be very stable at ~19% and ~9% (FWHM) respectively, and consistent with the values expected analytical predictions checked against pre-launch tests.Comment: 5 pages, 7 figures. Accepted for publication on A&A Special Issue on First Science with INTEGRA

The GAP-TPC

Several experiments have been conducted worldwide, with the goal of observing low-energy nuclear recoils induced by WIMPs scattering off target nuclei in ultra-sensitive, low-background detectors. In the last few decades noble liquid detectors designed to search for dark matter in the form of WIMPs have been extremely successful in improving their sensitivities and setting the best limits. One of the crucial problems to be faced for the development of large size (multi ton-scale) liquid argon experiments is the lack of reliable and low background cryogenic PMTs: their intrinsic radioactivity, cost, and borderline performance at 87 K rule them out as a possible candidate for photosensors. We propose a brand new concept of liquid argon-based detector for direct dark matter search: the Geiger-mode Avalanche Photodiode Time Projection Chamber (GAP-TPC) optimized in terms of residual radioactivity of the photosensors, energy and spatial resolution, light and charge collection efficiencyComment: 7 pages, 5 figures, Accepted for publication on JINS

Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease. Although genetic predisposition and epigenetic factors contribute to the development of NAFLD, our understanding of the molecular mechanism involved in the pathogenesis of the disease is still emerging. Here we investigated a possible role of a microRNAs-STAT3 pathway in the induction of hepatic steatosis. Differentiated HepaRG cells treated with the fatty acid sodium oleate (fatty dHepaRG) recapitulated features of liver vesicular steatosis and activated a cell-autonomous inflammatory response, inducing STAT3-Tyrosine-phosphorylation. With a genome-wide approach (Chromatin Immunoprecipitation Sequencing), many phospho-STAT3 binding sites were identified in fatty dHepaRG cells and several STAT3 and/or NAFLD-regulated microRNAs showed increased expression levels, including miR-21. Innovative CARS (Coherent Anti-Stokes Raman Scattering) microscopy revealed that chemical inhibition of STAT3 activity decreased lipid accumulation and deregulated STAT3-responsive microRNAs, including miR-21, in lipid overloaded dHepaRG cells. We were able to show in vivo that reducing phospho-STAT3-miR-21 levels in C57/BL6 mice liver, by long-term treatment with metformin, protected mice from aging-dependent hepatic vesicular steatosis. Our results identified a microRNAs-phosphoSTAT3 pathway involved in the development of hepatic steatosis, which may represent a molecular marker for both diagnosis and therapeutic targeting

BeppoSAX average spectra of Seyfert galaxies

We have studied the average 3-200 keV spectra of Seyfert galaxies of type 1 and 2, using data obtained with BeppoSAX. The average Seyfert 1 spectrum is well-fitted by a power law continuum with photon spectral index Gamma~1.9, a Compton reflection component R~0.6-1 (depending on the inclination angle between the line of sight and the reflecting material) and a high-energy cutoff at around 200 keV; there is also an iron line at 6.4 keV characterized by an equivalent width of 120 eV. Seyfert 2's on the other hand show stronger neutral absorption (NH=3-4 x 10^{22} atoms cm-2) as expected but are also characterized by an X-ray power law which is substantially harder (Gamma~1.75) and with a cut-off at lower energies (E_c~130 keV); the iron line parameters are instead substantially similar to those measured in type 1 objects. There are only two possible solutions to this problem: to assume more reflection in Seyfert 2 galaxies than observed in Seyfert 1 or more complex absorption than estimated in the first instance. The first possibility is ruled out by the Seyfert 2 to Seyfert 1 ratio while the second provides an average Seyfert 2 intrinsic spectrum very similar to that of the Seyfert 1. The extra absorber is likely an artifact due to summing spectra with different amounts of absorption, althought we cannot exclude its presence in at least some individual sources. Our result argues strongly for a very similar central engine in both type of galaxies as expected under the unified theory.Comment: 12 pages, 4 figures, to be published in ApJ Letter

IBIS/PICsIT in-flight performances

PICsIT (Pixellated Imaging CaeSium Iodide Telescope) is the high energy detector of the IBIS telescope on-board the INTEGRAL satellite. PICsIT operates in the gamma-ray energy range between 175 keV and 10 MeV, with a typical energy resolution of 10% at 1 MeV, and an angular resolution of 12 arcmin within a \~100 square degree field of view, with the possibility to locate intense point sources in the MeV region at the few arcmin level. PICsIT is based upon a modular array of 4096 independent CsI(Tl) pixels, ~0.70 cm^2 in cross-section and 3 cm thick. In this work, the PICsIT on-board data handling and science operative modes are described. This work presents the in-flight performances in terms of background count spectra, sensitivity limit, and imaging capabilities.Comment: 8 pages, 4 figures. Accepted for publication on A&A, special issue on First Science with INTEGRA

3EG J2027+3429 another Blazar behind the Galactic Plane

We report on the association of an X-ray source (WGA J2025.1+3342), serendipitously found with BeppoSAX in two separate observations, with the unidentified EGRET source 3EG J2027+3429. The source is detected from 1 keV up to about 100 keV, has a flat (0.6-1.5) spectrum and is highly variable both in intensity and shape. The data indicate marginal evidence for an iron line in the source rest frame. The overall X-ray luminosity is 4 10^{45} erg s^{-1} typical of a quasar. The X-ray source is coincident in radio with a bright object characterized by a flat spectrum over the band 0.3-10 GHz while in optical it is identified with a quasar at redshift 0.22. All available data indicate a SED compatible with a low frequency peaked or red blazar type object. This identification is interesting because this is the second blazar found behind the galactic plane in the direction of the Cygnus region.Comment: 6 pages, 5 figures, 3 tables, accepted for publication in A&