Precise measurement of the 222Rn half-life: a probe to monitor the stability of radioactivity

We give the results of a study on the 222Rn decay we performed in the Gran Sasso Laboratory (LNGS) by detecting the gamma rays from the radon progeny. The motivation was to monitor the stability of radioactivity measuring several times per year the half-life of a short lifetime (days) source instead of measuring over a long period the activity of a long lifetime (tens or hundreds of years) source. In particular, we give a possible reason of the large periodical fluctuations in the count rate of the gamma rays due to radon inside a closed canister which has been described in literature and which has been attributed to a possible influence of a component in the solar irradiation affecting the nuclear decay rates. We then provide the result of four half-life measurements we performed underground at LNGS in the period from May 2014 to January 2015 with radon diffused into olive oil. Briefly, we did not measure any change of the 222Rn half-life with a 8*10^-5 precision. Finally, we provide the most precise value for the 222Rn half-life: 3.82146(16){stat}(4){syst} days.Comment: Accepted for publication in Physics Letters B, 6 pages, 6 figure

Search for correlations between solar flares and decay rate of radioactive nuclei

The deacay rate of three different radioactive sources 40K, 137Cs and natTh has been measured with NaI and Ge detectors. Data have been analyzed to search for possible variations in coincidence with the two strongest solar flares of the years 2011 and 2012. No significant deviations from standard expectation have been observed, with a few 10-4 sensitivity. As a consequence, we could not find any effect like that recently reported by Jenkins and Fischbach: a few per mil decrease in the decay rate of 54Mn during solar flares in December 2006.Comment: 5 pages, 3 figure

Search for time modulations in the decay rate of 40K and 232Th

Time modulations at per mil level have been reported to take place in the decay constant of about 15 nuclei with period of one year (most cases) but also of about one month or one day. In this paper we give the results of the activity measurement of a 40K source and a 232Th one. The two experiments have been done at the Gran Sasso Laboratory during a period of about 500 days, above ground (40K) and underground (232Th) with a target sensitivity of a few parts over 10^5. We also give the results of the activity measurement at the time of the X-class solar flares which took place in May 2013. Briefly, our measurements do not show any evidence of unexpected time dependence in the decay rate of 40K and 232Th.Comment: version accepted for publication (Astroparticle Physics

Direct-acting antivirals and visceral leishmaniasis: A case report

Background: Visceral leishmaniasis is a vector-borne parasitic disease caused by protozoa belonging to the genus Leishmania. The clinical presentation of visceral leishmaniasis strictly depends on the host immunocompetency, whereas depressive conditions of the immune system impair the capability to resolve the infection and allow reactivation from sites of latency of the parasite. Case presentation: We describe a case of visceral leishmaniasis (VL) that occurred in a patient with chronic hepatitis C treated with direct-acting antiviral drugs (DAA). The hypothesized mechanism is the alteration of protective inflammation mechanisms secondary to DAA therapy. Downregulation of type II and III IFNs, their receptors, which accompany HCV clearance achieved during treatment with sofosbuvir and ribavirin might have a negative impact on a risk for reactivation of a previous Leishmania infection. We know indeed that IFN-\u3b3 is important to enhance killing mechanisms in macrophages, which are the primary target cells of Leishmania. Conclusion: Since VL is endemic in Sicily as well as in other countries of the Mediterranean basin, physicians should be aware of the possible unmasking of cryptic Leishmania infection by DAAs

Petrography, mineralogy and geochemistry of a primitive pumice from Stromboli: implications for the deep feeding system

We describe the field relations, petrographic, mineralogical and geochemical characteristics of an exceptional “golden” pumice belonging to a tephra layer exposed on the summit area of Stromboli volcano, Italy. Pumice sample PST-9 comes from a fallout deposit older than a spatter agglutinate sequence emplaced during the twentieth century. The eruption that produced it had a size exceeding that of intermediate paroxysms but was smaller than large-scale, spatter-forming, paroxysms from the sixteenth century and 1930 A.D. Lapilli are strongly vesicular and crystal-poor, similar to other “golden” pumices. Modal proportions include 89 vol% glass, 8 vol% clinopyroxene, 1–2 vol% olivine and 1–2 vol% plagioclase. Plagioclase is represented by reacted crystals coming from the shallow resident magma and incorporated in the pumice during eruption. A total of 74 and 44 crystals of olivine and clinopyroxene, respectively, were examined and 187 and 99 electron microprobe analyses obtained. Fo in olivine ranges between 70 and 92 mol% and Fs in clinopyroxene between 3 and 13 mol%. PST-9 hosts a higher proportion of Fo-rich olivine and Fs-poor clinopyroxene than the other “golden” pumices. Groundmass glasses are basaltic (Mg# = 66–69), as are most rim glasses around olivine and clinopyroxene, and glass inclusions in clinopyroxene. They are more primitive than in the other “golden” pumices. A few rim glasses and glass inclusions are shoshonitic (Mg# = 45–50). Most glass inclusions in olivine have CaO/Al2O3 higher than the other glasses and the whole-rock. PST-9 has the highest bulk MgO, CaO, Mg# and CaO/Al2O3 and the lowest FeOt of all “golden” pumices analysed to date. Analysis of Fe-Mg partitioning between olivine, clinopyroxene and melt allows three crystallization stages to be recognized. The first involves primitive mantle-derived melts (Mg# = 74–80), the second basaltic melts represented by groundmass glasses and the third is associated with more evolved melts represented by the shoshonitic glasses. The population of crystals in “golden” pumices is heterogeneous not only because of crystal incorporation from the shallow resident magma, but also because of pre-eruptive recharge of the deep reservoir with primitive melts. Differences between PST-9 and the other “golden” pumices in terms of groundmass glass composition and distribution of olivine and clinopyroxene compositions reflect contrasted replenishment rates of the deep reservoir with primitive liquids. Gabbroic inclusions in a clinopyroxene crystal provide a direct illustration of melt wall-rock interaction and stress the variability of the deep reservoir in terms of temperature, crystallinity and phase assemblages. Deep crystallization of plagioclase should be considered as a possibility at Stromboli. PST-9 is exceptionally well representative of the early magmatic evolution of “golden” pumices

Cluster of legionnaires’ disease in an Italian prison

Background: Legionella pneumophila (Lp) is the most common etiologic agent causing Legionnaires’ Disease (LD). Water systems offer the best growth conditions for Lp and support its spread by producing aerosols. From 2015 to 2017, the Regional Reference Laboratory of Clinical and Environmental Surveillance of Legionellosis of Palermo monitored the presence of Lp in nine prisons in Western Sicily. During this investigation, we compared Lp isolates from environmental samples in a prison located in Palermo with isolates from two prisoners in the same prison. Methods: We collected 93 water samples from nine Sicilian prisons and the bronchoalveolar lavages (BALs) of two prisoners considered cases of LD. These samples were processed following the procedures described in the Italian Guidelines for the Prevention and Control of Legionellosis of 2015. Then, genotyping was performed on 19 Lp colonies (17 from water samples and 2 from clinical samples) using the Sequence-Based Typing (SBT) method, according to European Study Group for Legionella Infections (ESGLI) protocols. Results: Lp serogroup (sg) 6 was the most prevalent serogroup isolated from the prisons analyzed (40%), followed by Lp sg 1 (16%). Most of all, in four penitentiary institutions, we detected a high concentration of Lp >104 Colony Forming Unit/Liter (CFU/L). The environmental molecular investigation found the following Sequence Types (STs) in Lp sg 6: ST 93, ST 292, ST 461, ST 728, ST 1317 and ST 1362, while most of the isolates in sg 1 belonged to ST 1. We also found a new ST that has since been assigned the number 2451 in the ESGLI-SBT database. From the several Lp sg 1 colonies isolated from the two BALs, we identified ST 2451. Conclusions: In this article, we described the results obtained from environmental and epidemiological investigations of Lp isolated from prisons in Western Sicily. Furthermore, we reported the first cluster of Legionnaires’ in an Italian prison and the molecular typing of Lp sg 1 from one prison’s water system and two BALs, identified the source of the contamination, and discovered a new ST

Light-meson leptonic decay rates in lattice QCD+QED

The leading electromagnetic (e.m.) and strong isospin-breaking corrections to the $\pi^+ \to \mu^+ \nu[\gamma]$ and $K^+ \to \mu^+ \nu[\gamma]$ leptonic decay rates are evaluated for the first time on the lattice. The results are obtained using gauge ensembles produced by the European Twisted Mass Collaboration with $N_f = 2 + 1 + 1$ dynamical quarks. The relative leading-order e.m.~and strong isospin-breaking corrections to the decay rates are 1.53(19)\% for $\pi_{\mu 2}$ decays and 0.24(10)\% for $K_{\mu 2}$ decays. Using the experimental values of the $\pi_{\mu 2}$ and $K_{\mu 2}$ decay rates and updated lattice QCD results for the pion and kaon decay constants in isosymmetric QCD, we find that the Cabibbo-Kobayashi-Maskawa matrix element $| V_{us}| = 0.22538(46)$, reducing by a factor of about $1.8$ the corresponding uncertainty in the Particle Data Group review. Our calculation of $|V_{us}|$ allows also an accurate determination of the first-row CKM unitarity relation $| V_{ud}|^2 + | V_{us}|^2 + | V_{ub}|^2 = 0.99988(46)$. Theoretical developments in this paper include a detailed discussion of how QCD can be defined in the full QCD+QED theory and an improved renormalisation procedure in which the bare lattice operators are renormalised non-perturbatively into the (modified) Regularization Independent Momentum subtraction scheme and subsequently matched perturbatively at $O(\alpha_{em}\alpha_s(M_W))$ into the W-regularisation scheme appropriate for these calculations.Comment: 63 pages, 10 figures and 2 tables. Version matches the published pape

Ambulatory surgery for perianal Crohn’s disease. Study of feasibility

Background. One-third of Crohn’s disease (CD) patients present perianal fistula. The gold standard in the diagnosis and treatment of symptomatic perianal disease (PAD) in CD is the exploration of the anal canal and distal rectum under anesthesia (EUA). This procedure is mainly conducted as a day case surgery. Unfortunately, it is not always possible to proceed within the ideal timing and any delay may well represent a relevant clinical issue. The aim of this study was to evaluate the feasibility of outpatient treatment of symptomatic perianal fistulas in CD patients. Methods. All CD patients under regular follow-up at our inflammatory bowel disease referral center, presenting with symptomatic perianal fistulas, were offered surgical consultation. The data of patients were prospectively collected for three years (February 2014 to February 2017) for the purpose of the study. All clinical information, including previous EUA and/or records from MRI and endoscopic ultrasound, was included. Outpatient anal canal and distal rectum exploration and treatment (OE) were undertaken during the specialist surgical consultation. Fistulas were classified according to Parks’s classification; the type of outpatient treatment and compliance of patients were recorded. Pain was assessed by VAS at the time of the procedure and during the first control. Patients were followed up in the surgical clinic in relation to the study. Results. Ninety-two CD patients with symptomatic perianal fistulas had surgical consultation during the study period. OE was offered to all but 18 patients who fulfilled the exclusion criteria or had an extremely severe disease; six patients refused the OE (8.11%). Of the 68 patients undergoing OE, eleven (16.18%) had previous surgery for perianal disease. The OE was accomplished in sixty-one patients (89.71%), while in 7 patients, it was abandoned for scarce compliance. Nine patients (14.75%) underwent drainage of perianal abscess; in 3 of them, it was possible to probe the fistula tract, find the internal orifice, and pass a loose seton. Overall, setonage was performed in 50 patients (81.97%). Rectovaginal setons were placed in 3 patients and more than one seton (up to 3) in 6 cases. Fistulotomy was performed in 4 simple subcutaneous fistulous tracts. Concordance with the preoperative findings was found in 54 out of 61 patients. EUA was scheduled at the time of OE for the 7 patients who did not complete the procedure. All sixty-one patients who had the OE were followed up for a minimum of 12 months. Conclusions. This preliminary study indicates that OE in CD patients with symptomatic perianal fistulas is safe and feasible in a high-volume referral center. It might provide several benefits, including patients’ logistics, reduce or remove patients’ symptoms and discomfort, allow for a timely start of medical therapy, and avoid further complications

Radon concentration in self-bottled mineral spring waters as a possible public health issue

Since 2013, the Council Directive 2013/51/Euratom has been regulating the content of radioactive substances in water intended for human consumption. However, mineral waters are exempted from this regulation, including self-bottled springs waters, where higher radon concentration are expected. Therefore, a systematic survey has been conducted on all the 33 mineral spring waters of Lazio (a region of Central Italy) in order to assess if such waters, when self-bottled, may be of concern for public health. Waters have been sampled in two different ways to evaluate the impact of bottling on radon concentration. Water sampling was possible for 20 different spring waters, with 6 samples for each one. The results show that 2 (10%) of measured mineral spring waters returned radon concentrations higher than 100 Bq L−1, i.e., the parametric value established by the Council Directive. These results, if confirmed by other surveys involving a higher number of mineral spring waters, would suggest regulating also these waters, especially in countries like Italy for which: (i) mineral water consumption is significant; (ii) mineral concession owners generally allow the consumers to fill bottles and containers, intended for transport and subsequent consumption, directly from public fountains or from fountains within the plant; (iii) the consumers’ habit of drinking self-bottled mineral water is widespread