A stroll in the energy landscape

We review recent results on the potential energy landscape (PES) of model liquids. The role of saddle-points in the PES in connecting dynamics to statics is investigated, confirming that a change between minima-dominated and saddle-dominated regions of the PES explored in equilibrium happens around the Mode Coupling Temperature. The structure of the low-energy saddles in the basins is found to be simple and hierarchically organized; the presence of saddles nearby in energy to the local minima indicates that, at non-cryogenic temperatures, entropic bottlenecks limit the dynamics.Comment: 8th International Workshop on Disordered Systems, Andalo (Trento), Italy, 12-15 March 200

Bifosfonati e disfunzione renale

Disphosphonates and renal impairmentOsteoporosis and chronic kidney disease (CKD) are two frequent pathological conditions in the adult and geriatric population and often coexist. These conditions ..

SAFE: Self-Attentive Function Embeddings for Binary Similarity

The binary similarity problem consists in determining if two functions are similar by only considering their compiled form. Advanced techniques for binary similarity recently gained momentum as they can be applied in several fields, such as copyright disputes, malware analysis, vulnerability detection, etc., and thus have an immediate practical impact. Current solutions compare functions by first transforming their binary code in multi-dimensional vector representations (embeddings), and then comparing vectors through simple and efficient geometric operations. However, embeddings are usually derived from binary code using manual feature extraction, that may fail in considering important function characteristics, or may consider features that are not important for the binary similarity problem. In this paper we propose SAFE, a novel architecture for the embedding of functions based on a self-attentive neural network. SAFE works directly on disassembled binary functions, does not require manual feature extraction, is computationally more efficient than existing solutions (i.e., it does not incur in the computational overhead of building or manipulating control flow graphs), and is more general as it works on stripped binaries and on multiple architectures. We report the results from a quantitative and qualitative analysis that show how SAFE provides a noticeable performance improvement with respect to previous solutions. Furthermore, we show how clusters of our embedding vectors are closely related to the semantic of the implemented algorithms, paving the way for further interesting applications (e.g. semantic-based binary function search).Comment: Published in International Conference on Detection of Intrusions and Malware, and Vulnerability Assessment (DIMVA) 201

Metodologie Tecnologiche nello Sport per promuovere l’Inclusione

The aim of this paper is to highlight the technological methodologies in the sportscontext, able to favor an inclusive process towards people forced to live in situationsof psycho-physical and social discomfort, such as the disabled.Like in the school system, where technology already provides an important supportin the proposal for an inclusive education, such innovations and tools are requiredto amplify the inclusive benefits that sport is able to generate.In this regard, we want to analyze a proposal for a technological strategy in the water polo discipline, with the aim of promoting the inclusion of the disabled.Lo scopo del paper è quello di evidenziare delle metodologiche di tipo tecnologiconel contesto sportivo in grado di favorire un processo inclusivo nei confrontidelle persone costrette in situazioni di disagio psico-fisico e sociale come i diversamenteabili.Al pari del sistema scolastico, dove la tecnologia fornisce già un importante supporto nella proposta di una didattica inclusiva, tali innovazioni e strumenti sonochiamati ad amplificare anche i benefici inclusivi che lo sport è capace di produrre.Si analizza, a tal proposito, una proposta di strategia tecnologica nello sport dellapallanuoto che mira a favorire l’inclusione dei diversamente abili

Basic fibroblast growth factor mediates carotid plaque instability through metalloproteinase-2 and –9 expression

OBJECTIVE(S): We hypothesized that basic fibroblast growth factor (bFGF) may exert a role in carotid plaque instability by regulating the expression of matrix metalloproteinases (MMP). METHODS: Plaques obtained from 40 consecutive patients undergoing carotid endarterectomy were preoperatively classified as soft or hard. Serum bFGF was pre- and postoperatively measured. The release of MMP-2 and MMP-9 in the blood serum, and the activity, production and expression in the carotid specimens was analyzed. Specific anti-bFGF inhibition tests were performed in vitro on human umbilical artery smooth muscle cells (HUASMC) to evaluate the role of bFGF in the activity, production and expression of MMP-2 and -9. RESULTS: Twenty-one (53%) patients had a soft carotid plaque and 19 (48%) a hard plaque. Preoperative bFGF serum levels were higher in patients with soft plaques [soft=34 (28-39) pg/mL and hard=20 (17-22) pg/mL-p<0.001] and postoperatively returned to normal values (when compared to 10 healthy volunteers). The serum levels of MMP-2 in patients' with soft plaques were higher than those in patients' with hard plaques [soft=1222 (1190-1252) ng/mL and hard=748 (656-793)ng/mL-p<0.0001]. MMP-9 serum values were 26 (22-29) ng/mL for soft plaques and 18 (15-21) ng/mL for hard plaques (p<0.0001). We found increased activity, production and expression of MMP-2 and -9 in soft plaques compared to hard plaques (p<0.001). In vitro inhibition tests on HUASMC showed the direct influence of bFGF on the activity, production and expression of MMP-2 and -9 (p<0.001). CONCLUSIONS: bFGF seems to exert a key role in carotid plaque instability regulating the activity, production and expression of MMP thus altering the physiologic homeostasis of the carotid plaque

Growth factors and experimental arterial grafts

Background: The production of growth factors from several experimental arterial conduits was determined. Methods: We implanted 105 experimental arterial grafts that were 1 cm long in the abdominal aorta of Lewis rats (average weight, 250 g). Five different types of grafts were analyzed: arterial isografts, vein grafts, arterial allografts, and polytetrafluoroethylene (PTFE) grafts with normal or decreased compliance. Animals were killed humanely 4 weeks after surgery and the production of platelet-derived growth factor (PDGF), basic fibroblast growth factor (bFGF), transforming growth factor-b, tumor necrosis factor-a, and interleukin-1 was analyzed. Results: Myointimal hyperplasia (MH) was evident in vein grafts, arterial allografts, and PTFE grafts, but not in arterial isografts. Growth factor production was increased for grafts prone to develop MH like vein, PTFE grafts, and arterial allografts. PDGF and bFGF were increased significantly for PTFE and vein grafts, but not for arterial allografts. The importance of bFGF and PGDF was confirmed by the capability of antibody to PDGF and to bFGF to reduce the mitogenic activity of smooth muscle cells, in vivo and in vitro, for PTFE and vein grafts, but not for arterial allografts, in which a predominant role was played by interleukin-1 and tumor necrosis factor-a. Conclusions: Agents able to neutralize this increased production of growth factors, either directly or by competition with their receptors, can prevent MH formation. (J Vasc Surg 2016;64:1444-9.) Clinical Relevance: Arterial grafts release growth factors, which can lead to myointimal hyperplasia formation and atherosclerosis progression in the arterial tree. Both phenomena can cause graft occlusion. Inhibition of growth factor release by arterial grafts can improve their clinical effectiveness

Risk factors for adenocarcinoma in the surgically transposed colon not exposed to the fecal stream. Etiological considerations extrapolated to sporadic colon carcinoma in the general population

The aim of the study was to analyze the clinical characteristics and outcomes of patients with de novo secondary adenocarcinoma arising in the operatively transposed colon not exposed to the fecal stream

Pain-motor integration in the primary motor cortex in Parkinson's disease

In Parkinson's disease (PD), the influence of chronic pain on motor features has never been investigated. We have recently designed a technique that combines nociceptive system activation by laser stimuli and primary motor cortex (M1) activation through transcranial magnetic stimulation (TMS), in a laser-paired associative stimulation design (Laser-PAS). In controls, Laser-PAS induces long-term changes in motor evoked potentials reflecting M1 long-term potentiation-like plasticity, arising from pain-motor integration