The synthesis and investigation of the antimicrobial activity of some new phenylselanyl-1-(toluene-4sulfonyl)-1H-tetrazole derivatives

The sulfonamide functional group has aroused interest in both medicinal and bioorganic chemistry. In this study, some new phenylselanyl-1-(toluene-4-sulfonyl)-1H-tetrazole derivatives (2a-f) have been synthesized using dicyclohexylcarbodiimide/dimethylaminopyridine (DCC/DMAP). The structures of the presently synthesized compounds were elucidated by spectroscopic methods [Fourier-transform infrared (FTIR) spectroscopy, (1)H nuclear magnetic resonance (NMR), (13)C nuclear magnetic resonance-attached proton test ((13)C NMR-APT), and mass spectrometry (MS)]. In addition, the antimicrobial activity of the synthesized compounds and two antibiotics [sulfamethoxazole (SMX) and sulfamerazine (SRZ)] were investigated against some microorganisms