Adjacent Consonants and the Universality of Sonority Sequencing Principle in Dotyali Dialects: Syllable Contact Analysis

This paper presents on all the possible adjacent consonant letters in Dotyali, one of the descendant language of Sanskrit, mainly spoken in Shudoor Paschim Nepal [sʊdʊrə-pəssɪmə] (Far-western) and compares the results of their phonological changes in seven local contemporary speech (dialects)：Doteli，Dadeldhuri，Bajhangi，Achhami，Baitadeli，Darchuli and Bajureli. Based on the corpus data from the field survey conducted in between July-September 2017 on a list of 1000 frequently used Dotyali words, this paper comes with a conclusion that even the onset clusters with rising sonority profile (except glides) are broken up by vowel epenthesis or simplify the clusters by deletion. It is revealed that dialects, except from the Achhami and Bajureli, the consonants with different degree of sonority across the syllable boundary tend to be changed due to syllable contact to meet Sonority hierchy, but the sonority distance between two consonants (coda and onset consonants) varies, therefore phonological changes like assimilation, dissimilation, desonorization, contact anaptyxis, contact methasis etc. goes differently. The phonological changes in Bajureli occurs maily due to other separate independent constraints

The Nexus of Corporate Affinity for Technology and Firm Sustainable Performance in the Era of Digitalization: A Mediated Model

This study aims to elaborate on the embeddedness of digital technology applications and their effect on firms’ sustainable performances under the mediating conditions of team innovation performance and digital organizational culture. The study employs a quantitative approach, and data were collected from 319 employees working in the information technology sector of China. Analyses of moment structures ((AMOS-version 27.0) and SPSS software- version 4.0) were used for data analysis, and the structural equation modeling (SEM) technique was utilized for hypothesis testing. The results show that a corporate affinity for technology has a positive and significant impact on sustainable performance, organizational digital culture, and team innovation performance. Organizational digital culture mediates the relationship between the corporate affinity for technology and sustainable performance. Team innovation performance mediates the relationship between the corporate affinity for technology and sustainable performance. The study contributes to business sustainability in terms of digitalization. Scholars and professionals can use the study as a guide for developing a business model that ensures the sustainable performance of firms. The research seeks to fill the existing gap in the literature concerning sustainable company performance by examining the potential for digitalization to enhance organizational sustainability. Firms need to prioritize investments in technology, they need to build a “tech-savvy” workforce, and they need to promote digital culture across the organization. A mixed-methods study would provide a more comprehensive understanding of this matter. For business leaders, this research provides important insights into how digital tools may be used to foster a productive work environment and ensure long-term success. The study profoundly elaborates on different interdependencies that influence the firms’ sustainable performances, and it suggests that managers should devise policies to enable technology acceptance

An analytical study to establish the role of Calendula Q as a topical wound dressing in partial-thickness burn wound

Objectives: The primary objective of this study was to evaluate the efficacy of Calendula officinalis in the wound healing of burn wound in comparison with standard povidone-iodine solution. Materials and Methods: A prospective randomized controlled study with 3 weeks of intervention and follow-up was conducted at the Department of Burns, Plastic and Maxillofacial Surgery, Safdarjung Hospital and VMMC, New Delhi, in collaboration with Homeopathic Treatment Centre, Safdarjung Hospital, New Delhi, from January 1, 2017, to December 31, 2018. The patients between 15 and 60 years of age reporting to the burns outpatient department with burn wounds due to thermal bums having the involvement of 5%–20% of total body surface area within 24 h of injury were randomized to either the Calendula (n = 20) or Betadine (n = 20) group. Results: There was no significant difference between the Calendula and Betadine groups, however, by day 14, 75% of cases in the Calendula group showed 80% and above epithelization as compared to 45.0% of cases in the Betadine group. Similarly, there was no significant difference between the wound discharges between the two groups but 95% had no discharge by the 14th day in the Calendula group as compared with 65% in the Betadine group. The Calendula group had a reduced incidence of wound infection when compared with Betadine. Conclusion: Therefore, Calendula dressing had a positive influence in early epithelization, better control of wound discharge, and lesser infections but these need to be evaluated on adequate sample size for a definite outcome

Ethyl 2‑Cyano-2-(4-nitrophenylsulfonyloxyimino)acetate-Mediated Lossen Rearrangement: Single-Pot Racemization-Free Synthesis of Hydroxamic Acids and Ureas from Carboxylic Acids

Ethyl 2-cyano-2-(4-nitrophenylsulfonyloxyimino)­acetate (4-NBsOXY) mediated Lossen rearrangement and its application for the synthesis of ureas is demonstrated. Required hydroxamic acids for the Lossen rearrangements were synthesized from carboxylic acids using the same reagent. Finally, reaction of an amine with the produced isocyanate resulted in urea. Good yields without racemization were achieved under milder and simpler reaction conditions. Reactions are compatible with common <i>N</i>-protecting groups, such as Boc, Fmoc, Cbz, and benzyl, as well as various OH protecting groups, such as ^tBu and Bzl. Conversion from carboxylic acid to urea is achieved in one pot. Most importantly, byproducts Oxyma [ethyl 2-cyano-2-(hydroxyimino)­acetate] and 4-nitrobenzenesulfonic acid can be recovered easily and can be recycled to prepare the reagent. Thus, the method is environmentally friendly and cost-effective

What determines the entrepreneurial intentions of employees? A moderated mediation model of entrepreneurial motivation and innovate work behavior

Innovation is a vital element of an organization's success. Companies must implement efficient, innovative plans and policies to consistently develop novel innovations. Based on the theory of planned behavior, the current framework formulated the idea of entrepreneurial education, entrepreneurial mindset, and technological knowledge with entrepreneurial intention in the healthcare industry. Further, this concept comprises the mediating role of innovative work behavior and the moderating effect of entrepreneurial motivation between constructs. The study adopted a quantitative method and collected data from 529 employees working in healthcare organizations (e.g., medical services, manufacturing medical equipment, and drugs/Pharmaceutical companies). The study's findings revealed that entrepreneurial education, entrepreneurial mindset, and technological knowledge positively and significantly affect entrepreneurial intention. The mediation results show that innovative work behavior significantly affects other constructs, and entrepreneurial motivation has a significant moderating effect. The study highlighted the notable transformations in the healthcare industry by proposing the need for relevant entrepreneurial education, traits, and characteristics in accelerating business activities. The study found a link between entrepreneurial education, mindset, technological knowledge, and entrepreneurial intention. This study is helpful for managers and practitioners in executing effective strategies for innovation in healthcare companies

Investigations of Peptide-Based Biocompatible Injectable Shape-Memory Hydrogels: Differential Biological Effects on Bacterial and Human Blood Cells

Here, we report the self-assembly of Amoc (9-anthracenemethoxycarbonyl)-capped dipeptides, which self-assemble to form injectable, self-healable, and shape-memory hydrogels with inherent antibacterial properties. Amoc-capped dipeptides self-assemble to form nanofibrillar networks, which are established by several spectroscopic and microscopic techniques. The inherent antibacterial properties of hydrogels are evaluated using two Gram-positive Staphylococcus aureus, Bacillus subtilis and three Gram-negative Escherichia coli, Pseudomonas aeruginosa, and Salmonella typhi bacteria. These hydrogels exhibit potent antibacterial efficacy against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentrations (MIC₅₀) for the hydrogels on Gram-positive bacteria are in the range of 10–200 μM hydrogelator concentrations. The biocompatibility and cytotoxicity of the hydrogels are evaluated using 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), hemolysis, and lipid peroxidation (LPO) assay on human blood cells. The hydrogels are hemocompatible and they decrease LPO values on human red blood cells probably via increased cellular stability against oxidative stress. Furthermore, MTT data show that the hydrogels are biocompatible and promote cell viability and proliferation on cultured human white blood cells. Taken together, these results may suggest that our designed injectable hydrogels could be useful to prevent localized bacterial infections