Formulation and evaluation of new polyherbal germicidal toothpaste containing ajwain oil

The main object of the present research is to provide a formulation useful as natural herbal tooth paste which obviates the drawbacks of the earlier tooth pastes.And its to provide a good tooth paste which can give effective protection to teeth and free them from any toxicity or toxic residue and irritation when regularly used. It should be cosmetically acceptable having pleasant odour and should not leave stain on teeth or fingers after use. Brightening the teeth by removing stains would be a prerequisite of the formulation.Still another object of the present invention is highlight the potential of extract of ajwain seed in inhibiting  the activity of Streptococcus mutans bacteria which are major cause of dental caries. The study attributed presence of naphthalene derivative responsible for such protective antibiofilm activity. Ajwain oil is proven to cure tooth pain. Along with equal parts of clove oil and water, it is used as home remedy to floss mouth and treat tooth ache, bad breath and tooth decay. Keywords: Halitosis, Gingivitis and Periodontiti

The study of cutaneous malignancies at a tertiary care hospital in central india

Background: There has been an alarming rise in the incidence of various diseases including that of cancer in the world with increase in the incidence of cutaneous malignancies owing to various changes that have taken place in the society over the past few years with respect to the culture, the lifestyle and also a contributory role has been played by the changes in the atmosphere as a result of increase in the air pollutants in the environment. Based on the scenario, we decided to conduct a study to evaluate the presentation and the management cutaneous malignancies in a teaching hospital set up in central india.Methods: A retrospective study was conducted between the time period of 1 year on the records of patients who were diagnosed with cutaneous and related malignancies who were treated at our Institute on a predesigned semi structured performa. SPSS version 23.0 was used for the analysis of the data collected.Results: We evaluated a total of 29 cases, Squamous cell carcinoma (SCC) was the most common histological type (51.72%) followed by melanoma (27.59%) and basal cell carcinoma (BCC, 20.69%). 75.86% of patients with cutaneous malignancies were males and 24.14% were females. Mortality rate observed was 13.7%.Conclusions: The most common cutaneous malignancy seen in this study was squamous cell carcinoma having increased propensity towards males than females. Rate of loco-regional disease and median disease-free survival is directly dependent on the adequacy of disease-free surgical margin and to the limited extent on the adjuvant therapy

Treatment and Outcomes of Early and Operable Recurrent Cervical Cancer: A Prospective Study

Objectives: The aim of this study was to evaluate outcomes, survival, patterns of recurrence, and morbidity in both early and recurrent operable cervical cancer patients following radical hysterectomy, pelvic lymph node dissection, and adjuvant radiotherapy. Materials and Methods: This was a prospective analysis of 55 patients of stage IA–IIA and recurrent operable cervical cancer treated with radical hysterectomy, pelvic lymphadenectomy, and adjuvant radiotherapy from 2014 to 2017. Overall survival (OS), disease-free survival (DFS), morbidity, and mortality rates were the end points of this study. Survival analysis was performed using the Kaplan–Meir method. Results: The median age of the study group was 45 years (range 18–68 years). The most common presentation was stage IB2 disease in 34.5% of patients. Fifty (90%) patients had squamous histology, whereas 5 (9.1%) had adenocarcinoma. Upfront radical hysterectomy was performed in 90.9% of patients, whereas 9.1% underwent surgery for recurrent cervical cancer. The most common indication for adjuvant radiotherapy was lymph node involvement, followed by parametrium involvement in 20% and 13% patients, respectively. Median follow-up period was 48 months (range 6–60 months). The OS and DFS rates were 85.0% and 81.8%, respectively. The most frequent complication encountered was paralytic ileus in 4 (7.2%) patients. Conclusion: Radical hysterectomy with pelvic lymphadenectomy for early cervical cancer has a favorable survival outcome with acceptable long-term morbidity

Spectrum of psychosocial dimensions of cancer in Indian scenario: An analytic review

Objective: Psycho-oncology refers to psychological, social, behavioral issues relatedto cancer prevention, treatment and survivorship. The prevalence of cancer in India is around 2.25 million with 1.1 million new cases per year. This  research analyzed  psychosocial  factors  affecting  the  victims  of  cancer  in  India  &  identified  various  dynamics  playing role in  management. Method: A prospective, cross-sectional study was performed over one year period. A psychosocial questionnaire was designed for collecting information. Based on this questionnaire, responses were recorded, reflecting patient’s feelings and experiences. This study was conducted at tertiary care centre RDGMC, Ujjain, India. The study group included 120 admitted patients. Results: Out of120 patients (54%) were males and (46%) were females. The sample included (50%) patients newly diagnosed with cancer &Head &Neck cancer was the commonest cancer, affecting (37%) patients. (41%) patients were compliant, (31%) patients were partially compliant, (28%) patients were non compliant to the treatment. (63%) patients continued treatment. (28%) patients abandoned the treatment& (9%) patients got deceased. Financial constraint was the commonest reason for abandonment accounting for 65 % of the patients. It was observed that (74%) patients experienced psychosocial stigma.&nbsp

The role of level IV neck dissection in early tongue cancer

To identify the rate of positive node / skip metastasis at level IV neck node in early carcinoma tongue after elective neck dissection. The records of fifty two patients were retrospectively reviewed from November 2016 to May 2018who underwent wide excision of tongue lesion with elective neck dissection for early tongue cancer. All the metastatic nodes were at the level from I-III. None of the patient had level IV/V neck node metastasis. Supra omohyoid neck dissection is adequate procedure for node negative early oral tongue cancer patients. The inclusion of level IV dissection should be intraoperative decision and should not be aggressive if no disease was found