Towards a Reproducible Pan-European Soil Erosion Risk Assessment - RUSLE

Soil is a valuable, non-renewable natural resource that offers a multitude of ecosystems goods and services. Given the increasing threat of soil erosion in Europe and the implications this has on future food security and water quality, it is important that land managers and decision makers are provided with accurate and appropriate information on the areas more prone to erosion phenomena. The present study shows an attempt to locate, at regional scale, the most sensitive areas and to highlight any changes of soil erosion trends with climate change. The choice of the input datasets is crucial as they have to offer the most homogeneous and complete covering at the pan-European level and to allow the produced information to be harmonized and easily validated. The model is based on available datasets (HWSD, SGDBE, SRTM, CLC and E-OBS) and The Revised Universal Soil Loss Equation (RUSLE) is used because of its flexibility and least data demanding. A significant effort has been made to select the better simplified equations to be used when a strict application of the RUSLE model was not possible. In particular for the computation of the Rainfall Erosivity factor a validation based on measured precipitation time series (having a temporal resolution of 10-15 minutes) has been implemented to be easily reproducible. The validation computational framework is available as free software. Designing the computational modeling architecture with the aim to ease as much as possible the future reuse of the model in analyzing climate change scenarios has also been a challenging goal of the research

Cigarette Smoke Suppresses Type I Interferon-Mediated Antiviral Immunity in Lung Fibroblast and Epithelial Cells

The objective of this study was to investigate the impact of cigarette smoke on innate antiviral defense mechanisms; specifically, we examined the effects of cigarette smoke on the induction of type I interferon (IFN). We observed a dose-dependent decrease in the ability of human lung fibroblast and epithelial cells to elicit an antiviral response against a viral double-strand RNA (dsRNA) mimic, polyI:C, in the presence of cigarette smoke-conditioned medium (SCM). Mechanistically, SCM decreases the expression of IFN-stimulated gene 15 (ISG15) and IFN regulatory factor-7 (IRF-7) transcripts and suppresses the nuclear translocation of key transcription factors, nuclear factor-κB (NF-κB) and IRF-3, after polyI:C stimulation. Furthermore, we provide evidence that the intercellular defense strategy against viral infection is also impaired. We observed a decrease in the ability of fibroblasts to elicit an antiviral state in response to IFN-β stimulation. This was associated with decreased nuclear translocation of phosphorylated Stat1 in response to IFN-β treatment. The effects elicited by SCM are reversible and are almost entirely abrogated in the presence of an antioxidant, such as glutathione. Our findings suggest that cigarette smoke affects the immediate-early, inductive, and amplification phases of the type I IFN response