Gross tumour volume delineation in anal cancer on T2-weighted and diffusion-weighted MRI - Reproducibility between radiologists and radiation oncologists and impact of reader experience level and DWI image quality

Abstract Purpose To assess how gross tumour volume (GTV) delineation in anal cancer is affected by interobserver variations between radiologists and radiation oncologists, expertise level, and use of T2-weighted MRI (T2W-MRI) vs. diffusion-weighted imaging (DWI), and to explore effects of DWI quality. Methods and materials We retrospectively analyzed the MRIs (T2W-MRI and b800-DWI) of 25 anal cancer patients. Four readers (Senior and Junior Radiologist; Senior and Junior Radiation Oncologist) independently delineated GTVs, first on T2W-MRI only and then on DWI (with reference to T2W-MRI). Maximum Tumour Diameter (MTD) was calculated from each GTV. Mean GTVs/MTDs were compared between readers and between T2W-MRI vs. DWI. Interobserver agreement was calculated as Intraclass Correlation Coefficient (ICC), Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD). DWI image quality was assessed using a 5-point artefact scale. Results Interobserver agreement between radiologists vs. radiation oncologists and between junior vs. senior readers was good–excellent, with similar agreement for T2W-MRI and DWI (e.g. ICCs 0.72–0.94 for T2W-MRI and 0.68–0.89 for DWI). There was a trend towards smaller GTVs on DWI, but only for the radiologists (P = 0.03–0.07). Moderate-severe DWI-artefacts were observed in 11/25 (44%) cases. Agreement tended to be lower in these cases. Conclusion Overall interobserver agreement for anal cancer GTV delineation on MRI is good for both radiologists and radiation oncologists, regardless of experience level. Use of DWI did not improve agreement. DWI artefacts affecting GTV delineation occurred in almost half of the patients, which may severely limit the use of DWI for radiotherapy planning if no steps are undertaken to avoid them

Determination of the neutral to charged current inclusive cross-section ratio for v and v interactions in the "Gargamelle" experiment

0SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Total cross sections for ve and ve interactions and search for neutrino oscillations and decay

About 200 and 60 candidates for electron neutrino and antineutrino interactions, respectively, have been analyzed in the heavy liquid bubble chamber Gargamelle exposed to the CERN PS neutrino beam. Evidence for scaling has been found for these interactions, with slopes of the cross sections in good agreement with those obtained for muon neutrino and antineutrino events in the same chamber. No evidence appears for oscillations of neutrinos or antineutrinos, which would induce in the present experiment an excess of electron or positron events. The corresponding limits are given as functions of the mixing parameter, for the finite mass Majorana neutrinos. The possibility of a multiplicative law for the lepton number has also been investigated. A search for isolated electron-positron pairs revealed no excess in the forward direction, in contradiction to the expectation for muonic neutrino and antineutrino decays. The corresponding limits on the c.m. half lifetimes are given. © 1978.0SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Measurement of the ratio of neutral current ν + p and ν + n inelastic cross sections below 10 GeV. Gargamelle neutrino propane experiment

The first measurement of the neutral current inelastic cross-section ratio σ(ν + n → v + .)/σ(ν + p →v + .) is presented. It is based on a sample of 573 neutral current events from the Gargamelle propane experiment using the CERN-PS neutrino beam. The ratio is found to be 0.76 -0.15 +0.17. The relative contributions of reactions on neutrons and protons are estimated from the charge and proton multiplicity distributions. This method was already successfully applied to charged current channels where an independent measurement of the cross-section ratio is possible. © 1978.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Experimental study of exclusive one-pion production in all neutrino-induced neutral current channels

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Observation of an excess of νe, νe events in a beam dump experiment at 400 GeV

A beam dump experiment has been performed at CERN in Gargamelle using the neutrino facility to look for penetrating particles produced either directly in the beam interaction or by prompt decay of new particles. A total of 32 interactions with a visible energy greater than 10 GeV has been found, classified, aftercorrections, into 18 charged current νμ or νμ, 5.1 neutral current and 8.9 νe or νe charged current events. An excess of νe events remains after all subtractions from any established sources. Results are presented in terms of the product of the cross section and the leptonic decay branching ratio of the possible source. © 1978.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Population pharmacokinetics and pharmacogenetics of ritonavir-boosted darunavir in the presence of raltegravir or tenofovir disoproxil fumarate/emtricitabine in HIV-infected adults and the relationship with virological response : a sub-study of the NEAT001/ANRS143 randomized trial

OBJECTIVES: NEAT001/ANRS143 demonstrated non-inferiority of once-daily darunavir/ritonavir (800/100 mg) + twice-daily raltegravir (400 mg) versus darunavir/ritonavir + tenofovir disoproxil fumarate/emtricitabine (245/200 mg once daily) in treatment-naive patients. We investigated the population pharmacokinetics of darunavir, ritonavir, tenofovir and emtricitabine and relationships with demographics, genetic polymorphisms and virological failure. METHODS: Non-linear mixed-effects models (NONMEM v. 7.3) were applied to determine pharmacokinetic parameters and assess demographic covariates and relationships with SNPs (SLCO3A1, SLCO1B1, NR1I2, NR1I3, CYP3A5*3, CYP3A4*22, ABCC2, ABCC10, ABCG2 and SCL47A1). The relationship between model-predicted darunavir AUC0-24 and C24 with time to virological failure was evaluated by Cox regression. RESULTS: Of 805 enrolled, 716, 720, 347 and 361 were included in the darunavir, ritonavir, tenofovir and emtricitabine models, respectively (11% female, 83% Caucasian). No significant effect of patient demographics or SNPs was observed for darunavir or tenofovir apparent oral clearance (CL/F); coadministration of raltegravir did not influence darunavir or ritonavir CL/F. Ritonavir CL/F decreased by 23% in NR1I2 63396C>T carriers and emtricitabine CL/F was linearly associated with creatinine clearance (P < 0.001). No significant relationship was demonstrated between darunavir AUC0-24 or C24 and time to virological failure [HR (95% CI): 2.28 (0.53-9.80), P = 0.269; and 1.82 (0.61-5.41), P = 0.279, respectively]. CONCLUSIONS: Darunavir concentrations were unaltered in the presence of raltegravir and not associated with virological failure. Polymorphisms investigated had little impact on study-drug pharmacokinetics. Darunavir/ritonavir + raltegravir may be an appropriate option for patients experiencing NRTI-associated toxicity