Dual JAK1 and STAT3 mutations in a breast implant-associated anaplastic large cell lymphoma.

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Book Reviews

An Estate Planner\u27s Handbook By Mayo Adams Shattuck Boston: Little, Brown & Company, 1948. Pp. 575. $7.50 reviewer: Philip A. Hendrick ================================ Estate Planning and Estate Tax Saving By Edward N. Polisher Philadelphia: George T. Bisel Company. Second Edition, 1948. 2 Volumes. Pp. xxxii, 923.$20.00 reviewer: Charles L.B. Lowndes =============================== Federal Taxes--Corporations and Partnerships, 1948-49 By Robert H. Montgomery, Conrad B. Taylor and Mark E. Richardson Vol. I: Gross Income and Deductions Vol. II: Taxes, Returns and Administration New York: The Ronald Press Company, 1948. Pp. xiii, 1001; pp. iv, 881. $20.00 Federal Taxes--Estates, Trusts and Gifts, 1948-49 By Robert H. Montgomery and James 0. Wynn New York: The Ronald Press Company,1948. Pp. xi, 1263.$10.00 reviewer: Adrian W. DeWind ================================ Wills, Gifts and Estate Planning Under the 1948 Revenue Act By Seymour S. Mintz, Richard C. Flesch and Bernard Soman Washington: The Bureau of National Affairs, Inc., 1948. Pp. 328. $2.00 reviewer: Chas. A. Morehead =============================== Federal Taxation for the Lawyer By Houstin Shockey New York: Prentice-Hall, Inc., Second Edition, 1947. Pp. xiii, 396.$5.00 reviewer: John R. Stiver

Dot Display Affects Approximate Number System Acuity and Relationships with Mathematical Achievement and Inhibitory Control

Much research has investigated the relationship between the Approximate Number System (ANS) and mathematical achievement, with continued debate surrounding the existence of such a link. The use of different stimulus displays may account for discrepancies in the findings. Indeed, closer scrutiny of the literature suggests that studies supporting a link between ANS acuity and mathematical achievement in adults have mostly measured the ANS using spatially intermixed displays (e.g. of blue and yellow dots), whereas those failing to replicate a link have primarily used spatially separated dot displays. The current study directly compared ANS acuity when using intermixed or separate dots, investigating how such methodological variation mediated the relationship between ANS acuity and mathematical achievement. ANS acuity was poorer and less reliable when measured with intermixed displays, with performance during both conditions related to inhibitory control. Crucially, mathematical achievement was significantly related to ANS accuracy difference (accuracy on congruent trials minus accuracy on incongruent trials) when measured with intermixed displays, but not with separate displays. The findings indicate that methodological variation affects ANS acuity outcomes, as well as the apparent relationship between the ANS and mathematical achievement. Moreover, the current study highlights the problem of low reliabilities of ANS measures. Further research is required to construct ANS measures with improved reliability, and to understand which processes may be responsible for the increased likelihood of finding a correlation between the ANS and mathematical achievement when using intermixed displays

Exploring the Demands of Assimilation among White Ethnic Majorities in Western Europe

This article was published in the journal, Journal of Ethnic and Migration Studies [© Routledge (Taylor & Francis)] and the definitive version is available at: http://dx.doi.org/10.1080/1369183X.2012.640015Since the mid-1990s, assimilation has gradually regained momentum as both a normative and an analytical concept for understanding the ways in which migrants are incorporated into societies at large. Although scholars have investigated various dimensions of this process, they have tended to privilege the experience of migrants themselves. Comparatively little attention has been dedicated to the perspective of the dominant groups, particularly in relation to what ethnic majority people demand that migrants do in order to be accepted. This article explores these demands of assimilation through qualitative data collected among white local elites in four regional case-studies in Western Europe. The analysis reveals a different picture from the one usually portrayed by 'new assimilation theory'. Accordingly, I suggest rethinking assimilation in ways which incorporate more fully the plurality of demands put forward by dominant ethnic groups. © 2012 Copyright Taylor and Francis Group, LLC

P13: Breast implant-associated anaplastic large-cell lymphoma presenting as a tumor mass and recurring as a seroma, with dual JAK1 and STAT3 mutations

Background: Breast implant-associated anaplastic large-cell lymphoma (BI-ALCL) is a rare subtype of ALK-negative ALCL arising specifically in association with breast implants, most often as a periprosthetic seroma. Most patients have excellent outcomes, with a tumor mass being an adverse prognostic factor. Information on genetic alterations is limited. In seven cases with reported NGS data, a few somatic mutations were detected including STAT3 S614R (two cases) or JAK1 G1097V (one case). We report genetic findings in paired BI-ALCL samples of a patient presenting with a tumor and recurring with a seroma. Methods: Primary and recurrent FFPE tumor samples were analyzed by a T-cell-lymphoma-customized NGS assay targeting 26 genes. Results: A 1943-born woman, with silicone breast implants since 1992, presented in 2011 with a right periprosthetic breast mass, without effusion. Tumorectomy showed a 2.8 cm infiltrating tumor of large anaplastic cells, positive for CD30, CD8, CD45RO, granzyme B and perforine, negative for ALK, EMA, CD2, CD3, CD4, CD5, CD7, CD15, CD20, CD45 and CD56. BI-ALCL was diagnosed and staged IE. CHOP polychemotherapy and autologous stem cell transplantation resulted in complete remission. In 2015 the disease recurred as a right periprosthetic seroma: the anaplastic cell proliferation, confined to the surface of the pseudocapsule, showed similar immunophenotype and TRgene rearrangements. NGS revealed pathogenic JAK1 (c.3290G>T, p.G1097V) and STAT3 (c.1840A>C, p.S614R) mutations in both specimens. Immunohistochemistry showed strong nuclear pSTAT3 expression, reflecting mutation-induced STAT3 activation. The patient is currently in complete remission. Conclusions: While single JAK1 or STAT3 mutations are found in other T-cell malignancies, dual JAK1/STAT3 mutations as observed in this BI-ALCL have so far been reported only in nodal ALK-negative ALCLs. Specifically, the JAK1 G1097V and STAT3 S614R variants found by us and others could represent recurrent drivers in BI-ALCL. Furthermore, similar molecular alterations seem to underlie both seroma and mass presentatio