Lasing Efficiency and Photochemical Stability of IR Laser

The lasing efficiencies and photochemical stabilities of laser dyes useful in the 710-1080-nm spectral region have been investigated using a Q-switched ruby laser pumping source. The measured bleaching rates P defined as the probability of irreversible decomposition of a dye molecule per absorbed photon, varied from <= 1 exp-5 to 3 exp-4 for the different dye-solvent combinations investigated. Broad-band lasing efficiencies (the ratios of dye laser output to ruby radiation input) ranged from 4 to 43 percent. Shifts of wavelength tuning range with variations in solvent, dye concentration, and dye laser cavity geometry are reported

Hot-wire Measurements in Low Reynolds Number Hypersonic Flows

Measurements were made of the heat loss and recovery temperature of a fine hot-wire at a nominal Mach number of 5.8. Data were obtained over an eight-fold range of Reynolds numbers in the transitional regime between continuum and free-molecule flow. At high Reynolds numbers, the heat transfer data agree well with the results of Laufer and McClellan, which were obtained at lower Mach numbers. At lower Reynolds numbers, the results indicate a monotonic transition between continuum and free molecule heat transfer laws. The slope of the heat transfer correlation also appears to vary monotonically, with Nu=√Re at high Reynolds numbers and Nu ~ Re for Re < < 1. Data on the wire recovery temperature (corresponding to zero net heat transfer) were obtained for free-stream Knudsen numbers between 0.4 and 3.0. Comparison with previous data suggests that for Mach numbers greater than about two the normalized variation of recovery temperature in the transitional regime is a unique function of the free-stream Knudsen number. The steady-state hot-wire may be used to obtain two thermodynamic measurements: the rate of heat transfer from the wire and the wire recovery temperature. An illustrative experiment was performed in the wake of a transverse cylinder, using both hot-wire and pressure instruments in a redundant system of measurements. It was shown that good accuracy may be obtained with a hot-wire even when the Reynolds number based on wire diameter is small

NACA Research Memorandums

Report presenting tests of an airplane model equipped with missiles to investigate the capability of that combination to achieve satisfactory launching and jettisoning of the missiles. Information about pylon modifications, missiles in launch positions, missile trajectory, and missiles in jettison positions is provided

In Silico Modeling of Shear-Stress-Induced Nitric Oxide Production in Endothelial Cells through Systems Biology

AbstractNitric oxide (NO) produced by vascular endothelial cells is a potent vasodilator and an antiinflammatory mediator. Regulating production of endothelial-derived NO is a complex undertaking, involving multiple signaling and genetic pathways that are activated by diverse humoral and biomechanical stimuli. To gain a thorough understanding of the rich diversity of responses observed experimentally, it is necessary to account for an ensemble of these pathways acting simultaneously. In this article, we have assembled four quantitative molecular pathways previously proposed for shear-stress-induced NO production. In these pathways, endothelial NO synthase is activated 1), via calcium release, 2), via phosphorylation reactions, and 3), via enhanced protein expression. To these activation pathways, we have added a fourth, a pathway describing actual NO production from endothelial NO synthase and its various protein partners. These pathways were combined and simulated using CytoSolve, a computational environment for combining independent pathway calculations. The integrated model is able to describe the experimentally observed change in NO production with time after the application of fluid shear stress. This model can also be used to predict the specific effects on the system after interventional pharmacological or genetic changes. Importantly, this model reflects the up-to-date understanding of the NO system, providing a platform upon which information can be aggregated in an additive way