6,644 research outputs found

    Complex permeability of soft magnetic ferrite polyester resin composites at frequencies above 1 MHz

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    Composite soft magnetic materials consist of magnetic particles in a non-magnetic matrix. The properties of such materials can be modelled using effective medium theory. Measurements have been made of the complex permeability of composites produced using ferrite powder and polyester resin. The success of various effective medium expressions in predicting the variation of complex permeability with composition has been assessed

    The translational potential of human induced pluripotent stem cells for clinical neurology: The translational potential of hiPSCs in neurology

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    The induced pluripotent state represents a decade-old Nobel prize-winning discovery. Human-induced pluripotent stem cells (hiPSCs) are generated by the nuclear reprogramming of any somatic cell using a variety of established but evolving methods. This approach offers medical science unparalleled experimental opportunity to model an individual patient's disease "in a dish." HiPSCs permit developmentally rationalized directed differentiation into any cell type, which express donor cell mutation(s) at pathophysiological levels and thus hold considerable potential for disease modeling, drug discovery, and potentially cell-based therapies. This review will focus on the translational potential of hiPSCs in clinical neurology and the importance of integrating this approach with complementary model systems to increase the translational yield of preclinical testing for the benefit of patients. This strategy is particularly important given the expected increase in prevalence of neurodegenerative disease, which poses a major burden to global health over the coming decades

    People's perceptions and classifications of sounds heard in urban parks : semantics, affect and restoration

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    Sounds have been broadly categorized by researchers into ‘human’, ‘nature’ and ‘mechanical’. It is less clear if the general public define and classify sounds in the same way and which factors influence their classification process. Establishing people’s classification and impression of urban park sounds helps identify their perception and experience of urban parks. This in turn aides the process of defining parks with reference to soundscapes, to produce an appreciated and potentially restorative place. This study involved urban park sounds, identified by park users, being presented in card sorts and survey items. Participants sorted the sounds into similar groups, in reference to a visited park. The terminology, factors involved and classification of the sounds was assessed using multidimensional scaling. Triangulation of the results suggests affect is a key factor in people’s classification process. Participants’ grouped sounds were labelled by affective terms more often than their perceived physical properties. Affective evaluations of each sound produced a similar classification structure as the card sort results. People’s classification structure also varied depending on how restorative they found their urban park. Furthermore schematic recollections played a part with many sounds being ‘expected’. Overall similarities and differences with ‘human’, ‘nature’ and ‘mechanical’ classifications were observed

    Performance interface document for users of Tracking and Data Relay Satellite System (TDRSS) electromechanically steered antenna systems (EMSAS)

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    Satellites that use the NASA Tracking and Data Relay Satellite System (TDRSS) require antennas that are crucial for performing and achieving reliable TDRSS link performance at the desired data rate. Technical guidelines are presented to assist the prospective TDRSS medium-and high-data rate user in selecting and procuring a viable, steerable high-gain antenna system. Topics addressed include the antenna gain/transmitter power/data rate relationship; Earth power flux-density limitations; electromechanical requirements dictated by the small beam widths, desired angular coverage, and minimal torque disturbance to the spacecraft; weight and moment considerations; mechanical, electrical and thermal interfaces; design lifetime failure modes; and handling and storage. Proven designs are cited and space-qualified assemblies and components are identified

    A study to explore the experiences of patient and family volunteers in a critical care environment: a phenomenological analysis

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    Introduction: ICU survivors suffer persistent physical, psychological and social problems in the months and years after discharge from critical care (1). Caregivers of these patients also suffer similar problems (2). As a result, an innovative, peer supported rehabilitation programme- Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) was created in Glasgow Royal Infirmary. This 5 week multi disciplinary programme, which is co facilitated by patient and family volunteers further along the recovery trajectory, aims to empower patients and caregivers to take control of their health and wellbeing. The objective of this study was to explore the experiences of the volunteers who participated in InS:PIRE. It also sought to identify the support required by volunteers from healthcare professionals involved in the project. Methods: Six in depth semi structured interviews were undertaken with volunteers (both patients and family members) involved in the InS:PIRE clinic by an assistant psychologist. A predetermined topic guide was utilised to guide interviews. Interviews were audio recorded and transcribed verbatim. Interpretative Phenomenological Analysis was used to analyse the transcripts (3). Peer Review was undertaken to ensure credibility of the findings. Results: Findings: Six key themes were identified from these interviews: the social impact of volunteering, shared experiences; supporting others; personal boundaries; support needs and personal gain. The importance of peer support and having a shared understanding of participants needs were key themes for the volunteers. Volunteers described the need for further support in areas such as: confidentiality; listening skills and understanding boundaries. Conclusions: The use of peer volunteers in this ICU rehabilitation service has been successful within this local context. Further, larger scale research studies, which explore further the impact of volunteering for ICU survivors are required

    VLA Observations of the Infrared Dark Cloud G19.30+0.07

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    We present Very Large Array observations of ammonia (NH3) (1,1), (2,2), and CCS (2_1-1_0) emission toward the Infrared Dark Cloud (IRDC) G19.30+0.07 at ~22GHz. The NH3 emission closely follows the 8 micron extinction. The NH3 (1,1) and (2,2) lines provide diagnostics of the temperature and density structure within the IRDC, with typical rotation temperatures of ~10 to 20K and NH3 column densities of ~10^15 cm^-2. The estimated total mass of G19.30+0.07 is ~1130 Msun. The cloud comprises four compact NH3 clumps of mass ~30 to 160 Msun. Two coincide with 24 micron emission, indicating heating by protostars, and show evidence of outflow in the NH3 emission. We report a water maser associated with a third clump; the fourth clump is apparently starless. A non-detection of 8.4GHz emission suggests that the IRDC contains no bright HII regions, and places a limit on the spectral type of an embedded ZAMS star to early-B or later. From the NH3 emission we find G19.30+0.07 is composed of three distinct velocity components, or "subclouds." One velocity component contains the two 24 micron sources and the starless clump, another contains the clump with the water maser, while the third velocity component is diffuse, with no significant high-density peaks. The spatial distribution of NH3 and CCS emission from G19.30+0.07 is highly anti-correlated, with the NH3 predominantly in the high-density clumps, and the CCS tracing lower-density envelopes around those clumps. This spatial distribution is consistent with theories of evolution for chemically young low-mass cores, in which CCS has not yet been processed to other species and/or depleted in high-density regions.Comment: 29 pages, 9 figures, accepted for publication by ApJ. Please contact the authors for higher resolution versions of the figure
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