Assessment of Tsunami Preparedness in East Coast of India through Mock drill conducted on 26 September, 2015

The 2004 Indian Ocean tsunami resulted in catastrophic losses of life and property and demonstrated how destructive the tsunamis can be. In India, the tsunami took away nearly 16,000 lives of the people living in the coastal areas and caused lot of damage to the property. The reason for such a great loss to lives and property is due to lack of awareness and preparedness to tsunamis. Keeping this in view and to avoid further future losses, the Government of India has established the Indian Tsunami Early Warning System at INCOIS, Hyderabad under the Ministry of Earth Sciences. While a tsunami cannot be prevented, its impact can be mitigated through community and emergency preparedness, timely warnings, effective response, and public education. The Tsunami drills evaluates the ability of warning centre and disaster offices to respond to a tsunami. The drills not only emphasize the testing of communications from warning centre to its stakeholders, but also provide an opportunity for testing national/state/local chains of command and decision-making, including the alerting and evacuation of people from selected coastal communitie

Successful monitoring of the 11 April 2012 tsunami off the coast of Sumatra by Indian Tsunami Early Warning Centre

The Indian Tsunami Early Warning Centre (ITEWC) in Hyderabad monitored the 11 April 2012 tsunami off the coast of Sumatra, which was generated by a shallow strike-slip earthquake and it largest aftershock of magnitude Mw (mB) 8.5 and 8.2 respectively, that occurred inside the subducting slab of the Indian plate. The earthquake generated a small ocean-wide tsunami that has been recorded by various tide gauges and tsunami buoys located in the Indian Ocean region. ITEWC detected the earthquake within 3 min 52 s and issued six advisories (bulletins) according to its Standard Operating Procedure. The ITEWC performed well during the event, and avoided false alarms and unnecessary public evacuations, especially in the mainland part of India region

The admissible tsunamigenic source region of 24 September 2013 land-based earthquake application of backward ray tracing technique

A minor tsunami of about 50 cm was generated along the coast of Qurayat near Makran subduction zone in the Arabian Sea due to the 24 September 2013 Pakistan earthquake of magnitude 7.6 Mw(mB),although its source was ~200 km far inland of the Makran trench. The real time sea level observation network in the Arabian Sea recorded minor tsunami arrivals. In an attempt to explain the mechanism of this unusual tsunami, we use backward ray tracing technique to map the admissible region of tsunamigenic source. Basically, in this technique the ray equations are integrated starting from the specific locations of tsunami observations, in all possible directions. The known travel time of the initial waves to the respective tide gauges and tsunami buoys is used in this method. Backward wave front is constructed by joining all endpoints of the rays from each of the locations. The region where the envelope of all backward wave fronts converges is considered as the source of the tsunami, which is ~470 km from the earthquake epicentre with the location at 24.8 N and 61.5E. The admissible region identified is an undersea section between Chabahar and Gwadar, where a mud island had appeared subsequent to this earthquake. Convergence of the tsunami source zone and location of the mud island suggest that the sudden uplift must have caused the tsunam

The Characterization of Helicobacter pylori DNA Associated with Ancient Human Remains Recovered from a Canadian Glacier

Helicobacter pylori is a gram-negative bacterium that colonizes the stomach of nearly half of the world's population. Genotypic characterization of H. pylori strains involves the analysis of virulence-associated genes, such as vacA, which has multiple alleles. Previous phylogenetic analyses have revealed a connection between modern H. pylori strains and the movement of ancient human populations. In this study, H. pylori DNA was amplified from the stomach tissue of the Kwäday Dän Ts'ìnchi individual. This ancient individual was recovered from the Samuel Glacier in Tatshenshini-Alsek Park, British Columbia, Canada on the traditional territory of the Champagne and Aishihik First Nations and radiocarbon dated to a timeframe of approximately AD 1670 to 1850. This is the first ancient H. pylori strain to be characterized with vacA sequence data. The Tatshenshini H. pylori strain has a potential hybrid vacA m2a/m1d middle (m) region allele and a vacA s2 signal (s) region allele. A vacA s2 allele is more commonly identified with Western strains, and this suggests that European strains were present in northwestern Canada during the ancient individual's time. Phylogenetic analysis indicated that the vacA m1d region of the ancient strain clusters with previously published novel Native American strains that are closely related to Asian strains. This indicates a past connection between the Kwäday Dän Ts'ìnchi individual and the ancestors who arrived in the New World thousands of years ago

Phylogeographic Analysis Elucidates the Influence of the Ice Ages on the Disjunct Distribution of Relict Dragonflies in Asia

Unusual biogeographic patterns of closely related groups reflect events in the past, and molecular analyses can help to elucidate these events. While ample research on the origin of disjunct distributions of different organism groups in the Western Paleartic has been conducted, such studies are rare for Eastern Palearctic organisms. In this paper we present a phylogeographic analysis of the disjunct distribution pattern of the extant species of the strongly cool-adapted Epiophlebia dragonflies from Asia. We investigated sequences of the usually more conserved 18 S rDNA and 28 S rDNA genes and the more variable sequences of ITS1, ITS2 and CO2 of all three currently recognised Epiophlebia species and of a sample of other odonatan species. In all genes investigated the degrees of similarity between species of Epiophlebia are very high and resemble those otherwise found between different populations of the same species in Odonata. This indicates that substantial gene transfer between these populations occurred in the comparatively recent past. Our analyses imply a wide distribution of the ancestor of extant Epiophlebia in Southeast Asia during the last ice age, when suitable habitats were more common. During the following warming phase, its range contracted, resulting in the current disjunct distribution. Given the strong sensitivity of these species to climatic parameters, the current trend to increasing global temperatures will further reduce acceptable habitats and seriously threaten the existences of these last representatives of an ancient group of Odonata

MiR-155 Induction by F. novicida but Not the Virulent F. tularensis Results in SHIP Down-Regulation and Enhanced Pro-Inflammatory Cytokine Response

The intracellular Gram-negative bacterium Francisella tularensis causes the disease tularemia and is known for its ability to subvert host immune responses. Previous work from our laboratory identified the PI3K/Akt pathway and SHIP as critical modulators of host resistance to Francisella. Here, we show that SHIP expression is strongly down-regulated in monocytes and macrophages following infection with F. tularensis novicida (F.n.). To account for this negative regulation we explored the possibility that microRNAs (miRs) that target SHIP may be induced during infection. There is one miR that is predicted to target SHIP, miR-155. We tested for induction and found that F.n. induced miR-155 both in primary monocytes/macrophages and in vivo. Using luciferase reporter assays we confirmed that miR-155 led to down-regulation of SHIP, showing that it specifically targets the SHIP 3′UTR. Further experiments showed that miR-155 and BIC, the gene that encodes miR-155, were induced as early as four hours post-infection in primary human monocytes. This expression was dependent on TLR2/MyD88 and did not require inflammasome activation. Importantly, miR-155 positively regulated pro-inflammatory cytokine release in human monocytes infected with Francisella. In sharp contrast, we found that the highly virulent type A SCHU S4 strain of Francisella tularensis (F.t.) led to a significantly lower miR-155 response than the less virulent F.n. Hence, F.n. induces miR-155 expression and leads to down-regulation of SHIP, resulting in enhanced pro-inflammatory responses. However, impaired miR-155 induction by SCHU S4 may help explain the lack of both SHIP down-regulation and pro-inflammatory response and may account for the virulence of Type A Francisella

Long Term Running Biphasically Improves Methylglyoxal-Related Metabolism, Redox Homeostasis and Neurotrophic Support within Adult Mouse Brain Cortex

Oxidative stress and neurotrophic support decline seem to be crucially involved in brain aging. Emerging evidences indicate the pro-oxidant methylglyoxal (MG) as a key player in the age-related dicarbonyl stress and molecular damage within the central nervous system. Although exercise promotes the overproduction of reactive oxygen species, habitual exercise may retard cellular aging and reduce the age-dependent cognitive decline through hormetic adaptations, yet molecular mechanisms underlying beneficial effects of exercise are still largely unclear. In particular, whereas adaptive responses induced by exercise initiated in youth have been broadly investigated, the effects of chronic and moderate exercise begun in adult age on biochemical hallmarks of very early senescence in mammal brains have not been extensively studied. This research investigated whether a long-term, forced and moderate running initiated in adult age may affect the interplay between the redox-related profile and the oxidative-/MG-dependent molecular damage patterns in CD1 female mice cortices; as well, we investigated possible exercise-induced effects on the activity of the brain derived neurotrophic factor (BDNF)-dependent pathway. Our findings suggested that after a transient imbalance in almost all parameters investigated, the lately-initiated exercise regimen strongly reduced molecular damage profiles in brains of adult mice, by enhancing activities of the main ROS- and MG-targeting scavenging systems, as well as by preserving the BDNF-dependent signaling through the transition from adult to middle age