118 research outputs found
Einleitung:Denken mit Haraway und Canguilhem
Wie wird das Leben zum Objekt des Wissens? Und wie gestaltet sich das Verhältnis von Leben, Wissenschaft und Technik? Donna J. Haraway und Georges Canguilhem verstehen diese Fragen als politische Fragen und Epistemologie als eine politische Praxis. Die besondere Aktualität von Canguilhems Denken leitet sich aus der von ihm gestellten Frage her, wie sich eine Geschichte der Rationalität des Wissens vom Leben schreiben lässt. Haraway bezieht sich nicht explizit auf Canguilhem, schließt jedoch an die von ihm gestellte Frage an
On two problems in graph Ramsey theory
We study two classical problems in graph Ramsey theory, that of determining
the Ramsey number of bounded-degree graphs and that of estimating the induced
Ramsey number for a graph with a given number of vertices.
The Ramsey number r(H) of a graph H is the least positive integer N such that
every two-coloring of the edges of the complete graph contains a
monochromatic copy of H. A famous result of Chv\'atal, R\"{o}dl, Szemer\'edi
and Trotter states that there exists a constant c(\Delta) such that r(H) \leq
c(\Delta) n for every graph H with n vertices and maximum degree \Delta. The
important open question is to determine the constant c(\Delta). The best
results, both due to Graham, R\"{o}dl and Ruci\'nski, state that there are
constants c and c' such that 2^{c' \Delta} \leq c(\Delta) \leq 2^{c \Delta
\log^2 \Delta}. We improve this upper bound, showing that there is a constant c
for which c(\Delta) \leq 2^{c \Delta \log \Delta}.
The induced Ramsey number r_{ind}(H) of a graph H is the least positive
integer N for which there exists a graph G on N vertices such that every
two-coloring of the edges of G contains an induced monochromatic copy of H.
Erd\H{o}s conjectured the existence of a constant c such that, for any graph H
on n vertices, r_{ind}(H) \leq 2^{c n}. We move a step closer to proving this
conjecture, showing that r_{ind} (H) \leq 2^{c n \log n}. This improves upon an
earlier result of Kohayakawa, Pr\"{o}mel and R\"{o}dl by a factor of \log n in
the exponent.Comment: 18 page
Induction of GADD34 Is Necessary for dsRNA-Dependent Interferon-β Production and Participates in the Control of Chikungunya Virus Infection
Nucleic acid sensing by cells is a key feature of antiviral responses, which generally result in type-I Interferon production and tissue protection. However, detection of double-stranded RNAs in virus-infected cells promotes two concomitant and apparently conflicting events. The dsRNA-dependent protein kinase (PKR) phosphorylates translation initiation factor 2-alpha (eIF2α) and inhibits protein synthesis, whereas cytosolic DExD/H box RNA helicases induce expression of type I-IFN and other cytokines. We demonstrate that the phosphatase-1 cofactor, growth arrest and DNA damage-inducible protein 34 (GADD34/Ppp1r15a), an important component of the unfolded protein response (UPR), is absolutely required for type I-IFN and IL-6 production by mouse embryonic fibroblasts (MEFs) in response to dsRNA. GADD34 expression in MEFs is dependent on PKR activation, linking cytosolic microbial sensing with the ATF4 branch of the UPR. The importance of this link for anti-viral immunity is underlined by the extreme susceptibility of GADD34-deficient fibroblasts and neonate mice to Chikungunya virus infection
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