E. Blythe Stason

His extreme modesty and unwillingness to advertise himself or permit others to extol him, his utter unselfishness, and his complete subordination of self and personal interests to those of the University and Law School to which he gave four decades of loyal and devoted service, have combined to leave biographical materials about Dean E. Blythe Stason, except for the most routine accounts, almost nonexistent. Writings by him are amazing in number and scope. Writings about him can scarcely be found. This is not because there is a lack of things to write about him and his many, brilliant accomplishments in the fields of law, education, administration and legal statesmanship. May one soon appear, with talents greater than those of this writer, to whom the time, opportunity and occasion may be made available for the necessary study, research and resultant writing. This alone could do him justice and permit the adequate paying of a richly deserved tribute. At the same time, it would add much to the public knowledge of how his achievements and many distinctions have helped to enhance the eminence and rich traditions of the Law School over whose destinies, for so long, he presided

Periorbitale Basalzellkarzinome und ihre Rezidive nach histologisch kontrollierter Exzision in der Klinik für Augenheilkunde, Universität des Saarlandes

Einführung: Die vorliegende retrospektive Arbeit beschäftigte sich mit periorbitalen Basalzellkarzinomen, die in der Klinik für Augenheilkunde am Universitätsklinikum des Saarlandes UKS in Homburg/Saar reseziert wurden. Ziel dieser Studie war es, die Rezidiventwicklung und mögliche Risikofaktoren zu untersuchen. Methoden: Diese Arbeit umfasst 270 Basalzellkarzinome von 243 Patienten, die im Zeitraum von 2009 bis 2020 in der Universitätsaugenklinik operiert wurden. Dabei wurden alle histopathologisch gesicherten Basalzellzellkarzinome mit mindestens einem Nachsorgebefund eingeschlossen. Grundlage der Datenerhebung waren die Klinikakten, denen die patienten- und tumorbezogenen Angaben, wie die genaue Lokalisation, die Art des Basalzellkarzinoms (primär oder bereits rezidiviert), die Anzahl der Eingriffe und die Art des Wundverschlusses bzw. der Defektdeckung entnommen werden konnten. Die histopathologischen Befundberichte wurden vom Institut für Allgemeine und Spezielle Pathologie des Universitätsklinikums des Saarlandes zur Verfügung gestellt. Ihnen konnten der jeweilige Subtyp des Basalzellkarzinoms und der Resektionsrandstatus der Exzision entnommen werden. Bei den Subtypen wurde zwischen solide/nodulär, superfiziell-multizentrisch, infiltrativ/sklerodermiform, basosquamös und gemischt/andere unterschieden. Ergebnisse: Bei den verschiedenen Tumorlokalisationen konnte kein signifikanter Unterschied zwischen den Rezidivraten nachgewiesen werden. Die bereits rezidivierten Basalzellkarzinome entwickelten signifikant häufiger (p<0,001) und eher (p<0,001) ein Rezidiv als die primären Basalzellkarzinome. Im Gesamtvergleich unterschieden sich die Rezidivraten der fünf definierten Subtypkategorien signifikant (p=0,005). Nach einer In-sano-Resektion war die Rezidivrate signifikant geringer als nach einer Non-in-sano-Resektion (p=0,008). Die Rezidivraten nach einzeitigen gegenüber mehrzeitigen Eingriffen bis zum Erreichen eines In-sano-Status wiesen keinen signifikanten Unterschied auf. Auch die exzidierte Gesamtfläche pro Behandlung und die zum Einsatz gekommenen Wundverschlüsse/Defektdeckungen ergaben keinen signifikanten Unterschied hinsichtlich der Rezidivraten. Schlussfolgerungen: Diese Arbeit konnte kein höheres Rezidivrisiko für bestimmte Lokalisationen innerhalb der Regio orbitalis nachweisen. Die Art des Basalzellkarzinoms (primär oder rezidiviert) und sein histologischer Subtyp hingegen scheinen das Rezidivrisiko zu beeinflussen. Insbesondere der superfiziell-multizentrische Subtyp fiel mit einer vergleichsweise hohen Rezidivrate auf. Die Überlegenheit der In-sano-Resektion gegenüber einer Non-in-sano-Resektion konnte für die Gesamtheit der BCC bestätigt werden, für einzelne Subtypen jedoch nicht. Die Anzahl der benötigten Eingriffe bis zum Erreichen einer In-sano-Resektion scheint das Rezidivrisiko nicht zu beeinflussen. Da auch mehrere Jahre nach einer Exzision Rezidive diagnostiziert wurden, sollte eine Langzeitnachsorge empfohlen werden.Introduction: The present retrospective study dealt with periorbital basal cell carcinomas resected at the Department of Ophthalmology at Saarland University Hospital UKS in Homburg/Saar. The aim of this study was to investigate recurrence development and possible risk factors. Methods: This study recorded 270 basal cell carcinomas from 243 patients who underwent surgery at the University Eye Hospital between 2009 and 2020. All histopathologically confirmed basal cell carcinomas with at least one follow-up finding were included. The data collection was based on the clinical files, from which the patient- and tumour-related information, such as the localisation of the basal cell carcinoma, the type of basal cell carcinoma (primary or recurrent), the number of operations and the type of wound closure or defect coverage could be taken. The histopathological reports were provided by the Institute of General and Special Pathology of Saarland University Hospital. The subtype of the basal cell carcinoma and the resection margin status of the excision could be taken from them. The subtypes were distinguished between solid/nodular, superficial-multicentric, infiltrative/sclerodermal, basosquamous and mixed/other. Results: No significant difference in recurrence rates could be demonstrated between different tumour localisations. The already recurrent basal cell carcinomas developed a recurrence significantly more frequently (p<0.001) and earlier (p<0.001) than the primary basal cell carcinomas. In the overall comparison, the five defined subtype categories resulted in significantly different recurrence rates (p=0.005). After in-sano resection, the recurrence rate was significantly lower than after non-in-sano resection (p=0.008). There was no significant difference in recurrence rates after single-stage versus multi-stage surgery until in-sano status was reached. The total excised area per treatment and the wound closures/defect coverage used also did not show a significant difference with respect to their recurrence rates. Conclusions: This study failed to demonstrate a higher risk of recurrence for specific locations within the orbital regio. However, the type of basal cell carcinoma (primary or recurrent) and its histological subtype seem to influence the risk of recurrence. The superficial-multicentric subtype stood out with a comparatively high recurrence rate. The superiority of in-sano resection over non-in-sano resection could be confirmed for BCC as a whole, but not for individual subtypes. The number of procedures required to achieve in-sano resection did not influence the risk of recurrence. Since recurrences were also diagnosed several years after excision, long-term follow-up should be recommended

THE INFLUENCE OF THIRD GENERATION ARTIFICIAL SOCCER TURF CHARACTERISTICS ON GROUND REACTION FORCES DURING RUNNING

The aim of this study was to determine the effect of different artificial soccer turf pitches on the ground reaction forces of running soccer players. For this purpose ground reaction forces were determined for twenty soccer players while they ran at three different speeds across a 25 meter long track covered with a third generation artificial soccer turf. Three different pitches, two FIFA 1star and one FIFA 2star, were examined. There was no difference between the two 1star systems in the peak vertical and horizontal ground reactions forces. Data on the 2star system was equivocal due to a too small sample size. It is concluded that surface characteristics influence the loading of the human muscle-skeletal system more subtly than initially anticipated. A more detailed biomechanical analysis of the events during impact is required to identify the critical loading parameters

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged murine HSCs. Here, we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain self-renewal capacity in serial transplantations. In primary transplantations, aged CD61High HSCs function similarly to young HSCs. CD61High HSCs are more quiescent than their CD61Low counterparts. We also show that in aged bone marrow, CD61High and CD61Low HSCs are transcriptomically distinct populations. Collectively, our research identifies CD61 as a key player in maintaining stem cell quiescence, ensuring the preservation of their functional integrity and potential during aging. Moreover, CD61 emerges as a marker to prospectively isolate a superior, highly dormant population of young and aged HSCs, making it a valuable tool both in fundamental and clinical research.</p

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged murine HSCs. Here, we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain self-renewal capacity in serial transplantations. In primary transplantations, aged CD61High HSCs function similarly to young HSCs. CD61High HSCs are more quiescent than their CD61Low counterparts. We also show that in aged bone marrow, CD61High and CD61Low HSCs are transcriptomically distinct populations. Collectively, our research identifies CD61 as a key player in maintaining stem cell quiescence, ensuring the preservation of their functional integrity and potential during aging. Moreover, CD61 emerges as a marker to prospectively isolate a superior, highly dormant population of young and aged HSCs, making it a valuable tool both in fundamental and clinical research.</p

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged murine HSCs. Here, we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain self-renewal capacity in serial transplantations. In primary transplantations, aged CD61High HSCs function similarly to young HSCs. CD61High HSCs are more quiescent than their CD61Low counterparts. We also show that in aged bone marrow, CD61High and CD61Low HSCs are transcriptomically distinct populations. Collectively, our research identifies CD61 as a key player in maintaining stem cell quiescence, ensuring the preservation of their functional integrity and potential during aging. Moreover, CD61 emerges as a marker to prospectively isolate a superior, highly dormant population of young and aged HSCs, making it a valuable tool both in fundamental and clinical research.</p

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged murine HSCs. Here, we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain self-renewal capacity in serial transplantations. In primary transplantations, aged CD61High HSCs function similarly to young HSCs. CD61High HSCs are more quiescent than their CD61Low counterparts. We also show that in aged bone marrow, CD61High and CD61Low HSCs are transcriptomically distinct populations. Collectively, our research identifies CD61 as a key player in maintaining stem cell quiescence, ensuring the preservation of their functional integrity and potential during aging. Moreover, CD61 emerges as a marker to prospectively isolate a superior, highly dormant population of young and aged HSCs, making it a valuable tool both in fundamental and clinical research.</p

CD61 identifies a superior population of aged murine HSCs and is required to preserve quiescence and self-renewal

Aging leads to a decline in function of hematopoietic stem cells (HSCs) and increases susceptibility to hematological disease. We found CD61 to be highly expressed in aged murine HSCs. Here, we investigate the role of CD61 in identifying distinct subpopulations of aged HSCs and assess how expression of CD61 affects stem cell function. We show that HSCs with high expression of CD61 are functionality superior and retain self-renewal capacity in serial transplantations. In primary transplantations, aged CD61High HSCs function similarly to young HSCs. CD61High HSCs are more quiescent than their CD61Low counterparts. We also show that in aged bone marrow, CD61High and CD61Low HSCs are transcriptomically distinct populations. Collectively, our research identifies CD61 as a key player in maintaining stem cell quiescence, ensuring the preservation of their functional integrity and potential during aging. Moreover, CD61 emerges as a marker to prospectively isolate a superior, highly dormant population of young and aged HSCs, making it a valuable tool both in fundamental and clinical research.</p

Facilitating Recovery of Daily Functioning in People With a Severe Mental Illness Who Need Longer-Term Intensive Psychiatric Services:Results From a Cluster Randomized Controlled Trial on Cognitive Adaptation Training Delivered by Nurses

Background: Feasible and effective interventions to improve daily functioning in people with a severe mental illness (SMI), such as schizophrenia, in need of longer-term rehabilitation are scarce. Aims: We assessed the effectiveness of Cognitive Adaptation Training (CAT), a compensatory intervention to improve daily functioning, modified into a nursing intervention. Method: In this cluster randomized controlled trial, 12 nursing teams were randomized to CAT in addition to treatment as usual (CAT; n = 42) or TAU (n = 47). Daily functioning (primary outcome) was assessed every 3 months for 1 year. Additional follow-up assessments were performed for the CAT group in the second year. Secondary outcomes were assessed every 6 months. Data were analyzed using multilevel modeling. Results: CAT participants improved significantly on daily functioning, executive functioning, and visual attention after 12 months compared to TAU. Improvements were maintained after 24 months. Improved executive functioning was related to improved daily functioning. Other secondary outcomes (quality of life, empowerment, negative symptoms) showed no significant effects. Conclusions: As a nursing intervention, CAT leads to maintained improvements in daily functioning, and may improve executive functioning and visual attention in people with SMI in need of longer-term intensive psychiatric care. Given the paucity of evidence-based interventions in this population, CAT can become a valuable addition to recovery-oriented care