432 research outputs found
Time and Fuel Optimal Controls in the Presence of Measurement Uncertainties
Time and fuel optimal control problems associated with controlling spacecraft under noisy measurements and bounded control input
Temperature-Dependent Pseudogaps in Colossal Magnetoresistive Oxides
Direct electronic structure measurements of a variety of the colossal
magnetoresistive oxides show the presence of a pseudogap at the Fermi energy
E_F which drastically suppresses the electron spectral function at E_F. The
pseudogap is a strong function of the layer number of the samples (sample
dimensionality) and is strongly temperature dependent, with the changes
beginning at the ferromagnetic transition temperature T_c. These trends are
consistent with the major transport trends of the CMR oxides, implying a direct
relationship between the pseudogap and transport, including the "colossal"
conductivity changes which occur across T_c. The k-dependence of the
temperature-dependent effects indicate that the pseudogap observed in these
compounds is not due to the extrinsic effects proposed by Joynt.Comment: 5 pages, 6 figures, submitted to Phys. Rev.
Collective Modes and the Superconducting State Spectral Function of Bi2212
Photoemission spectra of the high temperature superconductor Bi2212 near
(pi,0) show a dramatic change when cooling below Tc: the broad peak in the
normal state turns into a sharp low energy peak followed by a higher binding
energy hump. Recent experiments find that this low energy peak persists over a
significant range in momentum space. We show in this paper that these data are
well described by a simple model of electrons interacting with a collective
mode which appears only below Tc.Comment: 4 pages, revtex, 4 encapsulated postscript figure
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Structural basis for the membrane fusion step in Hantavirus entry
Hantaviruses are important emerging human pathogens and are the causative agents of serious diseases in humans with high mortality rates. Like other members in the Bunyaviridae family their M segment encodes two glycoproteins, GN and GC, which are responsible for the early events of the viral infection. Hantaviruses deliver their tripartite genome into the cytoplasm by fusion of the viral and endosomal membranes in response to the reduced pH of the endosome. Unlike phleboviruses (e.g. Rift valley fever virus), that have an icosahedral glycoprotein envelope, hantaviruses display a pleomorphic virion morphology as GN and GC assemble into spikes with apparent four- fold symmetry organized in a grid-like pattern on the viral membrane. We determined the crystal structure of glycoprotein C (GC) from Puumala virus (PUUV), a representative member of the Hantavirus genus. The crystal structure shows GC as the membrane fusion effector of PUUV and it presents a class II membrane fusion protein fold. Furthermore, GC was crystallized in its post-fusion trimeric conformation that until now had been observed only in Flavi- and Togaviridae family members. The PUUV G C structure together with our functional data provides new mechanistic insights into class II membrane fusion proteins and reveals new targets for membrane fusion inhibitors against these important pathogens. Both similarities and differences to other class II membrane fusion proteins implies a revise paradigm for the evolution of these unique proteins
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