Cost-effectiveness Study of Antihypertensive Drugs in Mumbai, India

Hypertension is a serious global public health problem. It accounts for 10% of all deaths in India and is the leading noncommunicable disease.1 Recent studies have shown that the prevalence of hypertension is 25% in urban and 10% in rural people in India.2 It exerts a substantial public health burden on cardiovascular health status and health care systems in India.3 Antihypertensive treatment effectively reduces hypertension-related morbidity and mortality.1 The cost of medications has always been a barrier to effective treatment

Chromomagnetic Dipole Moment of the Top Quark Revisited

We study the complete one-loop contributions to the chromagnetic dipole moment $\Delta\kappa$ of the top quark in the Standard Model, two Higgs doublet models, topcolor assited technicolor models (TC2), 331 models and extended models with a single extra dimension. We find that the SM predicts $\Delta\kappa = - 0.056$ and that the predictions of the other models are also consitent with the constraints imposed on $\Delta\kappa$ by low-energy precision measurements.Comment: 20 pages, 5 figures, Updat

Synthesis and in vitro anticancer activity of 6-chloro-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives: molecular docking and interaction with bovine serum albumin

A novel series of 6-chloro-7-methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one derivatives were synthesized. Structure of the newly synthesized compounds was established by their analytical and spectroscopic data. The title compounds were evaluated for their anticancer activity against human breast cancer (T-47D) and lung cancer (NCI-H226) cell lines. Effects of compounds on the cell morphology of these cell lines were studied. Among the series of compounds tested, 6-chloro-7-methyl-2-(4-((2-(piperidin-1-yl)ethylamino)methyl) phenyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one [MTDP4(9)] exhibited good anticancer activity against both cell lines. Further, the binding interaction of [MTDP4(9)] with bovine serum albumin has been investigated by UV, fluorescence and molecular docking studies

Synthesis and <i>in vitro</i> anticancer activity of 6-chloro-7-methyl-5<i>H</i>-[1,3,4]thiadiazolo[3,2-<i>a</i>]pyrimidin-5-one derivatives: molecular docking and interaction with bovine serum albumin

<p>A novel series of 6-chloro-7-methyl-5<i>H</i>-[1,3,4]thiadiazolo[3,2-<i>a</i>]pyrimidin-5-one derivatives were synthesized. Structure of the newly synthesized compounds was established by their analytical and spectroscopic data. The title compounds were evaluated for their anticancer activity against human breast cancer (T-47D) and lung cancer (NCI-H226) cell lines. Effects of compounds on the cell morphology of these cell lines were studied. Among the series of compounds tested, 6-chloro-7-methyl-2-(4-((2-(piperidin-1-yl)ethylamino)methyl) phenyl)-[1,3,4]thiadiazolo[3,2-<i>a</i>]pyrimidin-5-one [MTDP4(9)] exhibited good anticancer activity against both cell lines. Further, the binding interaction of [MTDP4(9)] with bovine serum albumin has been investigated by UV, fluorescence and molecular docking studies.</p

A New Polymorph of N,N '-Dimethylurea Characterized by X-ray Diffraction and First-Principles Lattice Dynamics Calculations

In this study we present a combined crystallographic and computational study of a new polymorph of N,N'-dimethylurea (DMU) with P2(1)2(1)2 space group symmetry, along with a revised theoretical study of the previously known phase in its corrected space group (Fdd2). X-ray diffraction studies show crystal structures that are very similar, differing only in the relative orientation of the hydrogen-bonded molecular chains that are common to both phases. The vibrational spectra were obtained from B3LYP hybrid functional lattice dynamics calculations and compared with the experimental data for the known phase. The free-energy difference between the forms is derived from the Gamma-point optical mode frequencies, and amounts to less than 1 kJ mol(-1) across the temperature range of interest. The electronic densities-of-states of both phases are also computed, yielding only marginal differences in valence and conduction band compositions and band gap widths. Taken together, the results highlight the small but important differences separating the two crystal lattices