A COMPARATIVE STUDY IN THE DIABETES MELLITUS PATIENTS FOR ORAL MANIFESTATION AT TERTIARY CARE HOSPITAL IN NORTH KARNATAKA

ABSTRACTObjective: Diabetes mellitus is the leading health problem across the world. It is associated with several complications such as retinopathy, neuropathy,oral manifestations, chronic macrovascular and microvascular complications. Our objective is to compare these oral manifestations in controlled anduncontrolled diabetic patients.Methods: A study was conducted on total of 100 diabetic patients. The patients were divided into two groups: Group I (n=50) consists of controlleddiabetic patients and Group II (n=50) consists of uncontrolled diabetic patients. Before, the start of the study proper oral examination was donefor both the groups. Samples were collected and were subjected to microbial examination. Comparison between both the groups was done for oralmanifestations.Results: It showed that uncontrolled diabetic patients had a higher incidence of oral manifestations such as hyposalivation, parotid enlargement,burning sensation of mouth, taste alterations, sialorrhea, dental carries, and microbial lesions than controlled diabetes patients.Conclusion: Uncontrolled diabetic patients had higher risk of oral manifestations than controlled diabetic individuals.Keywords: Diabetes mellitus, Retinopathy, Neuropathy, Oral manifestations, Periodontitis, Hyposalivation

Prevalence of dental caries in first and second permanent molars

Background:This study was conducted to assess the First and Second molar permanent molar caries in school children of Nalgonda district, Andhrapradesh, India.Methods:We have taken total 1800 school going children as study population age between 12-15 years, who lived in the same place since birth and consumed drinking water form single source.Results:The mean of caries in first and second were 0.12 ± 0.36 and 0.36 ± 0.70 respectively and total was 0.49 ± 0.92.Conclusion:The prevalence of Second molar teeth was found higher than First molar teeth and these caries were untreated

Laforin, a Dual Specificity Phosphatase Involved in Lafora Disease, Is Present Mainly as Monomeric Form with Full Phosphatase Activity

Lafora Disease (LD) is a fatal neurodegenerative epileptic disorder that presents as a neurological deterioration with the accumulation of insoluble, intracellular, hyperphosphorylated carbohydrates called Lafora bodies (LBs). LD is caused by mutations in either the gene encoding laforin or malin. Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases. In the current study, we investigated the functional and physiological relevance of laforin dimerization. We purified recombinant human laforin and subjected the monomer and dimer fractions to denaturing gel electrophoresis, mass spectrometry, phosphatase assays, protein-protein interaction assays, and glucan binding assays. Our results demonstrate that laforin prevalently exists as a monomer with a small dimer fraction both in vitro and in vivo. Of mechanistic importance, laforin monomer and dimer possess equal phosphatase activity, and they both associate with malin and bind glucans to a similar extent. However, we found differences between the two states' ability to interact simultaneously with malin and carbohydrates. Furthermore, we tested other members of the glucan phosphatase family. Cumulatively, our data suggest that laforin monomer is the dominant form of the protein and that it contains phosphatase activity

Conventional radiograph V/S CT for evaluation of sagittal fracture of mandibular condyle: A Case report

Condylar fractures of mandible are not very easy to diagnose radiographicaly. If fracture is vertical, it would be much more difficult to diagnose. Since treatment depends on type of fracture, CT scan is advised rather than conventional radiographs to diagnose condylar fractures.The cases reporting to the hospital during the period of July 2019 to April 2020 were enrolled, of which 2 cases have been reported here. It was observed that there are chances of missing the diagnosis of the condylar fracture if only the conventional radiographs are used. CT along with conventional radiographs should be considered for better treatment and management of the patients with maxillofacial injuries