ELECTROCHEMICAL DETERMINATION OF THE INTERACTION BETWEEN ANTICANCER DRUG CAPECITABINE AND DNA BY CARBON PASTE ELECTRODE

In this study, the interaction of an anticancer drug, Capecitabine with DNA was investigated by electrochemical methods using carbon paste electrode (CPE). The interaction of Capecitabine with single-stranded Calf thymus DNA (ss DNA) and double-stranded Calf thymus DNA (ds DNA) at electrode surface, or in solution phase was investigated by monitoring the changes at the oxidation signal of guanin base of DNA measured by differential pulse voltammetry (DPV) technique. Impedimetric measurements were performed by electrochemical impedance spectroscopy technique that also confirmed that ds DNA was immobilized onto the electrode surface. The detection limit (DL) in the case of interaction of Capecitabine with dsDNA and ssDNA interaction was calculated and found to be 17.35µg/mL and 17.12µg/mL, respectively

Dövme yöntemi ile madalyon üretiminin analizi.

Coins and medallions are manufactured by using coining process which is a metal forming process. In coining of medallions, there is a strong need to shorten the production time and reduce the production cost and waste of material in conventional coining method. An alternative coining method may be considered in order to reduce the production time and the manufacturing cost. In this study, a new method has been proposed. In the proposed method, design of the medallion is performed by utilizing computer aided engineering (CAE) environment and the master die is manufactured by means of NC codes. The modular designs of blanking and coining die sets for medallions with a diameter in the range of 30-90 mm have been realized. Coining and blanking processes for production of the medallion have been simulated by using a commercial finite volume program. Moreover, a commemorative medallion for the opening ceremony of METU-BILTIR Center Forging Research and Application Laboratory has been designed. After die sets have been manufactured, the real-life experiments have been conducted by using 1000 tones mechanical forging press and 200 tones eccentric press available in Forging Research and Application Laboratory of the METU-BILTIR Center. The results have been compared with the computer simulations. After the real-life experiments, it has been observed that medallions have successfully been obtained by employing the new proposed method. Therefore, the new proposed method for coining has been verified.M.S. - Master of Scienc