On the hopping pattern design for D2D Discovery

The hopping pattern for D2D Discovery are investi- gated. We propose three metrics for hopping pattern performance evaluation: column period, maximal collision ratio, maximal con- tinual collision number. A class of hopping patterns is constructed based on the metrics, and through simulation the patterns show better discovery performance

Reactive power planning for regional power grids based on active and reactive power adjustments of DGs

To deal with extreme overvoltage scenarios with small probabilities in regional power grids, the traditional reactive power planning model requires a huge VAR compensator investment. Obviously, such a decision that makes a large investment to cope with a small probability event is not economic. Therefore, based on the scenario analysis of power outputs of distributed generations and load consumption, a novel reactive power planning model considering the active and reactive power adjustments of distributed generations is proposed to derive the optimal allocation of VAR compensators and ensure bus voltages within an acceptable range under extreme overvoltage scenarios. The objective of the proposed reactive power planning model is to minimize the VAR compensator investment cost and active power adjustment cost of distributed generations. Moreover, since the proposed reactive power planning model is formulated as a mixed-integer nonlinear programming problem, a primal-dual interior point method-based particle swarm optimization algorithm is developed to effectively solve the proposed model. Simulation results were conducted with the modified IEEE 30-bus system to verify the effectiveness of the proposed reactive power planning model

Influence of Ag micro-alloying on the thermal stability and ageing characteristics of a Cu–14Fe in-situ composite

This paper studied the influence of Ag micro-alloying on the thermal stability and ageing characteristics of a deformation-processed Cu–14Fe in-situ composite prepared by thermo-mechanical processing. Heat treatment caused (i) edge recession, longitudinal splitting, cylinderization, break-up and spheroidisation of the Fe fibres in the Ag micro-alloyed Cu–14Fe in-situ composite, and (ii) recovery, recrystallisation and precipitation in the Cu matrix. Ag micro-alloying caused these processes to occur at lower temperatures. The index Z (a combination figure of merit that assesses the service performance) reached the peak value of 3.3×10 MPa·% IACS after isothermal heat treatment at 500 °C for 1 h, where IACS is the International Annealed Copper Standard, a measure of conductivity. The optimum combinations of tensile strength and conductivity were 1033 MPa and 56.6% IACS; 931 MPa and 58.9% IACS; or 851 MPa and 60.6% IACS. The tensile strength and conductivity of Ag micro-alloyed Cu–14Fe in-situ composite at η=7.8 after isochronal heat treatments were higher than those of the Cu–14Fe in-situ composite at each temperature

Prognostic factors of the short-term outcomes of patients with hepatitis B virus-associated acute-on-chronic liver failure

OBJECTIVE: To investigate the impact of the baseline status of patients with hepatitis B virus-associated acute-on-chronic liver failure on short-term outcomes. METHODS: A retrospective study was conducted that included a total of 138 patients with hepatitis B virus-associated acute-on-chronic liver failure admitted to the Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, from November 2013 to October 2016. The patients were divided into a poor prognosis group (74 patients) and a good prognosis group (64 patients) based on the disease outcome. General information, clinical indicators and prognostic scores of the patients’ baseline status were analyzed, and a prediction model was established accordingly. RESULTS: Elder age, treatment with artificial liver support systems and the frequency of such treatments, high levels of white blood cells, neutrophils, neutrophil count/lymphocyte count ratio, alanine aminotransferase, gamma-glutamyl transferase, total bilirubin, urea, and prognostic scores as well as low levels of albumin and sodium were all significantly associated with the short-term outcomes of hepatitis B virus-associated acute-on-chronic liver failure. The predictive model showed that logit (p) = 3.068 + 1.003 × neutrophil count/lymphocyte count ratio - 0.892 × gamma-glutamyl transferase - 1.138 × albumin - 1.364 × sodium + 1.651 × artificial liver support therapy. CONCLUSION: The neutrophil count/lymphocyte count ratio and serum levels of gamma-glutamyl transferase, albumin and sodium were independent risk factors predicting short-term outcomes of hepatitis B virus-associated acute-on-chronic liver failure, and the administration of multiple treatments with artificial liver support therapy during the early stage is conducive to improved short-term outcomes

Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients

BACKGROUND: Although many of the recently approved genomically targeted therapies have improved outcomes for patients in non–small-cell lung cancer (NSCLC) with lung adenocarcinoma, little is known about the genomic alterations that drive lung squamous cell cancer (SCC) and development of effective targeted therapies in lung SCC is a promising area to be further investigated. Discoidin domain receptor 2 (DDR2), is a novel receptor tyrosine kinases that respond to several collagens and involved in tissue repair, primary and metastatic cancer progression. METHODS: Expression of DDR2 mRNA was analyzed in 54 lung SCC tissues by qRT-PCR. Over-expression approaches were used to investigate the biological functions of DDR2 and its’ mutations in lung SCC cells. Conventional Sanger sequencing was used to investigate the mutations of DDR2 gene in 86 samples. The effect of DDR2 and its’ mutations on proliferation was evaluated by MTT and colony formation assays; cell migration and invasion was evaluated by trasnwell assays. Lung SCC cells stably transfected with pEGFP-DDR2 WT, pEGFP-DDR2-S131C or empty vector were injection into nude mice to study the effect of DDR2 and its’ mutation on tumorigenesis in vivo. Protein and mRNA expression levels of E-cadherin and MMP2 were determined by qRT-PCR and western blot analysis. Differences between groups were tested for significance using Student’s t-test (two-tailed). RESULTS: In this study, we found that DDR2 mRNA levels were significantly decreased in 54 lung SCC tissues compared with normal lung tissues. Moreover, there were 3 novel DDR2 mutations (G531V, S131C, T681I) in 4 patients and provide the mutation rate of 4.6% in the 86 patients with lung SCC. The mutation of S131C in DDR2 could promote lung SCC cells proliferation, migration and invasion via inducing MMP-2, but reducing E-cadherin expression. CONCLUSIONS: These data indicated that the novel DDR2 mutation may contribute to the development and progression of lung SCC and this effect may be associated with increased proliferation and invasiveness, at least in part, via regulating E-cadherin expression

Photocatalytic and Magnetic Behaviors Observed in BiFeO 3

Perovskite-type BiFeO3 nanofibers with wave nodes-like morphology were prepared by electrospinning. The nanofibers show a highly enhanced visible-light-active photocatalytic property. The results also showed that the diameter could affect the band gap and photocatalytic performances of nanofibers. Additionally, weak ferromagnetic behaviors can be observed at room temperature, which should be correlated to the size-confinement effect on the magnetic ordering of BiFeO3 structure