Digging the population of compact binary mergers out of the noise

Coalescing compact binaries emitting gravitational wave (GW) signals, as recently detected by the Advanced LIGO-Virgo network, constitute a population over the multi-dimensional space of component masses and spins, redshift, and other parameters. Characterizing this population is a major goal of GWobservations and may be approached via parametric models.We demonstrate hierarchical inference for such models with a method that accounts for uncertainties in each binary merger’s individual parameters, for mass-dependent selection effects, and also for the presence of a second population of candidate events caused by detector noise. Thus, the method is robust to potential biases from a contaminated sample and allows us to extract information from events that have a relatively small probability of astrophysical origin

Transcriptomic profiling of 39 commonly-used neuroblastoma cell lines

Neuroblastoma cell lines are an important and cost-effective model used to study oncogenic drivers of the disease. While many of these cell lines have been previously characterized with SNP, methylation, and/or mRNA expression microarrays, there has not been an effort to comprehensively sequence these cell lines. Here, we present raw whole transcriptome data generated by RNA sequencing of 39 commonly-used neuroblastoma cell lines. These data can be used to perform differential expression analysis based on a genetic aberration or phenotype in neuroblastoma (e.g., MYCN amplification status, ALK mutation status, chromosome arm 1p, 11q and/or 17q status, sensitivity to pharmacologic perturbation). Additionally, we designed this experiment to enable structural variant and/or long-noncoding RNA analysis across these cell lines. Finally, as more DNase/ATAC and histone/transcription factor ChIP sequencing is performed in these cell lines, our RNA-Seq data will be an important complement to inform transcriptional targets as well as regulatory (enhancer or repressor) elements in neuroblastoma

A polymerase chain reaction/ligase detection reaction fluorescent microsphere assay to determine Plasmodium falciparum MSP-119 haplotypes

The merozoite surface protein-1 (MSP-1) is a blood stage antigen currently being tested as a vaccine against Plasmodium falciparum malaria. Determining the MSP-1(19) haplotype(s) present during infection is essential for assessments of MSP-1 vaccine efficacy and studies of protective immunity in human populations. The C-terminal fragment (MSP-1(19)) has four predominant haplotypes based on point mutations resulting in non-synonymous amino acid changes: E-TSR (PNG-MAD20 type), E-KNG (Uganda-PA type), Q-KNG (Wellcome type), and Q-TSR (Indo type). Current techniques using direct DNA sequencing are laborious and expensive. We present an MSP-1(19) allele-specific polymerase chain reaction (PCR)/ligase detection reaction-fluorescent microsphere assay (LDR-FMA) that allows simultaneous detection of the four predominant MSP-1(19) haplotypes with a sensitivity and specificity comparable with other molecular methods and a semi-quantitative determination of haplotype contribution in mixed infections. Application of this method is an inexpensive, accurate, and high-throughput alternative to distinguish the predominant MSP-1(19) haplotypes in epidemiologic studies

Microreactor cells for high throughput x-ray absorption spectroscopy

High-throughput experimentation has been applied to X-ray Absorption spectroscopy as a novel route for increasing research productivity in the catalysis community. Suitable instrumentation has been developed for the rapid determination of the local structure in the metal component of precursors for supported catalysts. An automated analytical workflow was implemented that is much faster than traditional individual spectrum analysis. It allows the generation of structural data in quasi-real time. We describe initial results obtained from the automated high throughput (HT) data reduction and analysis of a sample library implemented through the 96 well-plate industrial standard. The results show that a fully automated HT-XAS technology based on existing industry standards is feasible and useful for the rapid elucidation of geometric and electronic structure of materials

An Absolute Flux Density Measurement of the Supernova Remnant Casseopia A at 32 GHz

We report 32 GHz absolute flux density measurements of the supernova remnant Cas A, with an accuracy of 2.5%. The measurements were made with the 1.5-meter telescope at the Owens Valley Radio Observatory. The antenna gain had been measured by NIST in May 1990 to be $0.505 \pm 0.007 \frac{{\rm mK}}{{\rm Jy}}$. Our observations of Cas A in May 1998 yield $S_{cas,1998} = 194 \pm 5 {\rm Jy}$. We also report absolute flux density measurements of 3C48, 3C147, 3C286, Jupiter, Saturn and Mars.Comment: 30 pages, 4 figures; accepted for publication by AJ. Revised systematic error budget, corrected typos, and added reference

The Radio Variability of the Gravitational Lens PMN J1838-3427

We present the results of a radio variability study of the gravitational lens PMN J1838-3427. Our motivation was to determine the Hubble constant by measuring the time delay between variations of the two quasar images. We monitored the system for 4 months (approximately 5 times longer than the expected delay) using the Australia Telescope Compact Array at 9 GHz. Although both images were variable on a time scale of a few days, no correlated intrinsic variability could be identified, and therefore no time delay could be measured. Notably, the fractional variation of the fainter image (8%) was greater than that of the brighter image (4%), whereas lensed images of a point source would have the same fractional variation. This effect can be explained, at least in part, as the refractive scintillation of both images due to the turbulent interstellar medium of the Galaxy.Comment: To appear in AJ (8 pages, including 4 figures

High Throughput In Situ XAFS Screening of Catalysts

We outline and demonstrate the feasibility of high-throughput (HT) in situ XAFS for synchrotron radiation studies. An XAS data acquisition and control system for the analysis of dynamic materials libraries under control of temperature and gaseous environments has been developed. The system is compatible with the 96-well industry standard and coupled to multi-stream quadrupole mass spectrometry (QMS) analysis of reactor effluents. An automated analytical workflow generates data quickly compared to traditional individual spectrum acquisition and analyses them in quasi-real time using an HT data analysis tool based on IFFEFIT. The system was used for the automated characterization of a library of 91 catalyst precursors containing ternary combinations of Cu, Pt, and Au on ?-Al2O3, and for the in situ characterization of Au catalysts supported on Al2O3 and TiO2

ALMA High-frequency Long Baseline Campaign in 2017:Band-to-band Phase Referencing in Submillimeter Waves

In 2017, an Atacama Large Millimeter/submillimeter Array (ALMA) high-frequency long baseline campaign was organized to test image capabilities with baselines up to 16 km at submillimeter (submm) wavelengths. We investigated image qualities using ALMA receiver Bands 7, 8, 9, and 10 (285-875 GHz) by adopting band-to-band (B2B) phase referencing in which a phase calibrator is tracked at a lower frequency. For B2B phase referencing, it is expected that a closer phase calibrator to a target can be used, comparing to standard in-band phase referencing. In the first step, it is ensured that an instrumental phase offset difference between low- and high-frequency Bands can be removed using a differential gain calibration in which a phase calibrator is certainly detected while frequency switching. In the next step, comparative experiments are arranged to investigate the image quality between B2B and in-band phase referencing with phase calibrators at various separation angles. In the final step, we conducted long baseline imaging tests for a quasar at 289 GHz in Band 7 and 405 GHz in Band 8 and complex structure sources of HL Tau and VY CMa at ~670 GHz in Band 9. The B2B phase referencing was successfully applied, allowing us to achieve an angular resolution of 14x11 and 10x8 mas for HL Tau and VY CMa, respectively. There is a high probability of finding a low-frequency calibrator within 5.4 deg in B2B phase referencing, bright enough to use an 8 s scan length combined with a 7.5 GHz bandwidth.Comment: 61 pages, 17 figures, 8 table