Renormalization effects on neutrino masses and mixing in a string-inspired SU(4) X SU(2)_L X SU(2)_R X U(1)_X model

We discuss renormalization effects on neutrino masses and mixing angles in a supersymmetric string-inspired SU(4) X SU(2)_L X SU(2)_R X U(1)_X model, with matter in fundamental and antisymmetric tensor representations and singlet Higgs fields charged under the anomalous U(1)_X family symmetry. The quark, lepton and neutrino Yukawa matrices are distinguished by different Clebsch-Gordan coefficients. The presence of a second U(1)_X breaking singlet with fractional charge allows a more realistic, hierarchical light neutrino mass spectrum with bi-large mixing. By numerical investigation we find a region in the model parameter space where the neutrino mass-squared differences and mixing angles at low energy are consistent with experimental data.Comment: 9 pages, 7 figures; references adde

Software verification plan for GCS

This verification plan is written as part of an experiment designed to study the fundamental characteristics of the software failure process. The experiment will be conducted using several implementations of software that were produced according to industry-standard guidelines, namely the Radio Technical Commission for Aeronautics RTCA/DO-178A guidelines, Software Consideration in Airborne Systems and Equipment Certification, for the development of flight software. This plan fulfills the DO-178A requirements for providing instructions on the testing of each implementation of software. The plan details the verification activities to be performed at each phase in the development process, contains a step by step description of the testing procedures, and discusses all of the tools used throughout the verification process

Sub-millimeter images of a dusty Kuiper belt around eta Corvi

We present sub-millimeter and mid-infrared images of the circumstellar disk around the nearby F2V star eta Corvi. The disk is resolved at 850um with a size of ~100AU. At 450um the emission is found to be extended at all position angles, with significant elongation along a position angle of 130+-10deg; at the highest resolution (9.3") this emission is resolved into two peaks which are to within the uncertainties offset symmetrically from the star at 100AU projected separation. Modeling the appearance of emission from a narrow ring in the sub-mm images shows the observed structure cannot be caused by an edge-on or face-on axisymmetric ring; the observations are consistent with a ring of radius 150+-20AU seen at 45+-25deg inclination. More face-on orientations are possible if the dust distribution includes two clumps similar to Vega; we show how such a clumpy structure could arise from the migration over 25Myr of a Neptune mass planet from 80-105AU. The inner 100AU of the system appears relatively empty of sub-mm emitting dust, indicating that this region may have been cleared by the formation of planets, but the disk emission spectrum shows that IRAS detected an additional hot component with a characteristic temperature of 370+-60K (implying a distance of 1-2AU). At 11.9um we found the emission to be unresolved with no background sources which could be contaminating the fluxes measured by IRAS. The age of this star is estimated to be ~1Gyr. It is very unusual for such an old main sequence star to exhibit significant mid-IR emission. The proximity of this source makes it a perfect candidate for further study from optical to mm wavelengths to determine the distribution of its dust.Comment: 22 pages, 4 figures. Scheduled for publication in ApJ 10 February 2005 issu

Evaluation of a novel assay for detection of the fetal marker RASSF1A: facilitating improved diagnostic reliability of noninvasive prenatal diagnosis

BackgroundAnalysis of cell free fetal (cff) DNA in maternal plasma is used routinely for non invasive prenatal diagnosis (NIPD) of fetal sex determination, fetal rhesus D status and some single gene disorders. True positive results rely on detection of the fetal target being analysed. No amplification of the target may be interpreted either as a true negative result or a false negative result due to the absence or very low levels of cffDNA. The hypermethylated RASSF1A promoter has been reported as a universal fetal marker to confirm the presence of cffDNA. Using methylation-sensitive restriction enzymes hypomethylated maternal sequences are digested leaving hypermethylated fetal sequences detectable. Complete digestion of maternal sequences is required to eliminate false positive results.MethodscfDNA was extracted from maternal plasma (n = 90) and digested with methylation-sensitive and insensitive restriction enzymes. Analysis of RASSF1A, SRY and DYS14 was performed by real-time PCR.ResultsHypermethylated RASSF1A was amplified for 79 samples (88%) indicating the presence of cffDNA. SRY real time PCR results and fetal sex at delivery were 100% accurate. Eleven samples (12%) had no detectable hypermethylated RASSF1A and 10 of these (91%) had gestational ages less than 7 weeks 2 days. Six of these samples were male at delivery, five had inconclusive results for SRY analysis and one sample had no amplifiable SRY.ConclusionUse of this assay for the detection of hypermethylated RASSF1A as a universal fetal marker has the potential to improve the diagnostic reliability of NIPD for fetal sex determination and single gene disorders

GCS programmer's manual

A variety of instructions to be used in the development of implementations of software for the Guidance and Control Software (GCS) project is described. This document fulfills the Radio Technical Commission for Aeronautics RTCA/DO-178A guidelines, 'Software Considerations in Airborne Systems and Equipment Certification' requirements for document No. 4, which specifies the information necessary for understanding and programming the host computer, and document No. 12, which specifies the software design and implementation standards that are applicable to the software development and testing process. Information on the following subjects is contained: activity recording, communication protocol, coding standards, change management, error handling, design standards, problem reporting, module testing logs, documentation formats, accuracy requirements, and programmer responsibilities

Letter. On the activation of [CrCl3{R-SN(H)S-R}] catalysts for selective trimerization of ethene: a freeze-quench Cr K-edge XAFS study

Homogeneous chromium catalysts for the selective conversion of ethene to hex-1-ene are formed from Cr(III) reagents, amino-thioether ligands of the type HN(CH2CH2SR)2, and aluminum reagents. In this study the early activation steps are investigated by EPR, UV-visible and Cr K-edge XAFS spectroscopy; rapid stopped-flow mixing and a freeze-quench allows good quality EXAFS analysis of a species formed in ~ 1 second of reaction. This is shown to involve reduction to Cr(II) and deprotonation of a NH group of the auxiliary ligand. This 4-coordinate metal-center may act as precursor for the coordination of ethene and subsequent selective oligomerization

A Mid-Infrared Imaging Survey of Embedded Young Stellar Objects in the Rho Ophiuchi Cloud Core

Results of a comprehensive, new, ground-based mid-infrared imaging survey of the young stellar population of the Rho Ophiuchi cloud are presented. Data were acquired at the Palomar 5-m and at the Keck 10-m telescopes with the MIRLIN and LWS instruments, at 0.25 arcsec and 0.25 arcsec resolutions, respectively. Of 172 survey objects, 85 were detected. Among the 22 multiple systems observed, 15 were resolved and their individual component fluxes determined. A plot of the frequency distribution of the detected objects with SED spectral slope shows that YSOs spend ~400,000 yr in the Flat Spectrum phase, clearing out their remnant infall envelopes. Mid-infrared variability is found among a significant fraction of the surveyed objects, and is found to occur for all SED classes with optically thick disks. Large-amplitude near-infrared variability, also found for all SED classes with optically thick disks, seems to occur with somewhat higher frequency at the earlier evolutionary stages. Although a general trend of mid-infrared excess and NIR veiling exists proceeding through SED classes, with Class I objects generally exhibiting K-veilings > 1, Flat Spectrum objects with K-veilings > 0.58, and Class III objects with K-veilings =0, Class II objects exhibit the widest range of K-band veiling values, 0-4.5. However, the highly variable value of veiling that a single source can exhibit in any of the SED classes in which active disk accretion can take place is striking, and is direct observational evidence for highly time-variable accretion activity in disks. Finally, by comparing mid-infrared vs. near-infrared excesses in a subsample with well-determined effective temperatures and extinction values, disk clearing mechanisms are explored. The results are consistent with disk clearing proceeding from the inside-out.Comment: 18 pages + 5 tables + 7 figure