Development and testing of the AXBT real-time editing system (ARES)

Author Posting. © American Meteorological Society, 2021. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of the Atmospheric and Oceanic Technology 38(1), (2021): 3-16, https://doi.org/10.1175/JTECH-D-20-0110.1.Airborne expendable bathythermographs (AXBTs) are air-launched, single-use temperature–depth probes that telemeter temperature observations as VHF-modulated frequencies. This study describes the AXBT Real-Time Editing System (ARES), which is composed of two components: the ARES Data Acquisition System, which receives telemetered temperature–depth profiles with no external hardware other than a VHF radio receiver, and the ARES Profile Editing System, which quality controls AXBT temperature–depth profiles. The ARES Data Acquisition System performs fast Fourier transforms on windowed segments of the demodulated signal transmitted from the AXBT. For each segment, temperature is determined from peak frequency and depth from elapsed time since profile start. Valid signals are distinguished from noise by comparing peak signal levels and signal-to-noise ratios to predetermined thresholds. When evaluated using 387 profiles, the ARES Data Acquisition System produced temperature–depth profiles nearly identical to those generated using a Sippican MK-21 processor, while reducing the amount of noise from VHF interference included in those profiles. The ARES Profile Editor applies a series of automated checks to identify and correct common profile discrepancies before displaying the profile on an editing interface that provides simple user controls to make additional corrections. When evaluated against 1177 tropical Atlantic and Pacific AXBT profiles, the ARES automated quality control system successfully corrected 87% of the profiles without any required manual intervention. Necessary future work includes improvements to the automated quality control algorithm and algorithm evaluation against a broader dataset of temperature–depth profiles from around the world across all seasons.This work was sponsored by the Office of Naval Research (Grants N000141812819 and N0001420WX00345) and the U.S. Navy’s Civilian Institution Office with the MIT–WHOI Joint Program

QBO influence on MJO amplitude over the Maritime Continent: Physical mechanisms and seasonality

Author Posting. © American Meteorological Society, 2019. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Monthly Weather Review 147(1), (2019): 389-406. doi: 10.1175/MWR-D-18-0158.1.The quasi-biennial oscillation (QBO) is stratified by stratospheric zonal wind direction and height into four phase pairs [easterly midstratospheric winds (QBOEM), easterly lower-stratospheric winds, westerly midstratospheric winds (QBOWM), and westerly lower-stratospheric winds] using an empirical orthogonal function analysis of daily stratospheric (100–10 hPa) zonal wind data during 1980–2017. Madden–Julian oscillation (MJO) events in which the MJO convective envelope moved eastward across the Maritime Continent (MC) during 1980–2017 are identified using the Real-time Multivariate MJO (RMM) index and the outgoing longwave radiation (OLR) MJO index (OMI). Comparison of RMM amplitudes by the QBO phase pair over the MC (RMM phases 4 and 5) reveals that boreal winter MJO events have the strongest amplitudes during QBOEM and the weakest amplitudes during QBOWM, which is consistent with QBO-driven differences in upper-tropospheric lower-stratospheric (UTLS) static stability. Additionally, boreal winter RMM events over the MC strengthen during QBOEM and weaken during QBOWM. In the OMI, those amplitude changes generally shift eastward to the eastern MC and western Pacific Ocean, which may result from differences in RMM and OMI index methodologies. During boreal summer, as the northeastward-propagating boreal summer intraseasonal oscillation (BSISO) becomes the dominant mode of intraseasonal variability, these relationships are reversed. Zonal differences in UTLS stability anomalies are consistent with amplitude changes of eastward-propagating MJO events across the MC during boreal winter, and meridional stability differences are consistent with amplitude changes of northeastward-propagating BSISO events during boreal summer. Results remain consistent when stratifying by neutral ENSO phase.The authors are grateful for the funding provided by the Office of Naval Research Propagation of Intra-Seasonal Tropical Oscillations (ONR PISTON) Award N0001416WX01752 and the USNA Trident Scholar program. The authors also appreciate the helpful comments of the two external reviewers.2019-07-0

Lung Injury Pathways: Adenosine Receptor 2B Signaling Limits Development of Ischemic Bronchiolitis Obliterans Organizing Pneumonia

Purpose/Aim of the Study: Adenosine signaling was studied in bronchiolitis obliterans organizing pneumonia (BOOP) resulting from unilateral lung ischemia. Materials and Methods: Ischemia was achieved by either left main pulmonary artery or complete hilar ligation. Sprague–Dawley (SD) rats, Dahl salt sensitive (SS) rats and SS mutant rat strains containing a mutation in the A2B adenosine receptor gene (Adora2b) were studied. Adenosine concentrations were measured in bronchoalveolar lavage (BAL) by HPLC. A2A (A2AAR) and A2B adenosine receptor (A2BAR) mRNA and protein were quantified. Results: Twenty-four hours after unilateral PA ligation, BAL adenosine concentrations from ischemic lungs were increased relative to contralateral lungs in SD rats. A2BAR mRNA and protein concentrations were increased after PA ligation while miR27a, a negatively regulating microRNA, was decreased in ischemic lungs. A2AAR mRNA and protein concentrations remained unchanged following ischemia. A2BAR protein was increased in PA ligated lungs of SS rats after 7 days, and 4 h after complete hilar ligation in SD rats. SS-Adora2b mutants showed a greater extent of BOOP relative to SS rats, and greater inflammatory changes. Conclusion: Increased A2BAR and adenosine following unilateral lung ischemia as well as more BOOP in A2BAR mutant rats implicate a protective role for A2BAR signaling in countering ischemic lung injury

Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide

Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem. Inflammatory responses to infections are reproduced by lipopolysaccharide (LPS) engaging Toll-like receptor 4 (TLR4). Apoptosis is a hallmark of lung injury in sepsis. This study was conducted to determine whether preexposure to LPS or hypoxia modulated the survival of pulmonary artery endothelial cells (PAECs). We also investigated the role TLR4 receptor expression plays in apoptosis due to these conditions. Bovine PAECs were cultured in hypoxic or normoxic environments and treated with LPS. TLR4 antagonist TAK-242 was used to probe the role played by TLR4 receptors in cell survival. Cell apoptosis and survival were measured by caspase 3 activity and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) incorporation. TLR4 expression and tumor necrosis factor α (TNF-α) production were also determined. LPS increased caspase 3 activity in a TAK-242-sensitive manner and decreased MTT incorporation. Apoptosis was decreased in PAECs preconditioned with hypoxia prior to LPS exposure. LPS increased TNF-α production, and hypoxic preconditioning blunted it. Hypoxic preconditioning reduced LPS-induced TLR4 messenger RNA and TLR4 protein. TAK-242 decreased to baseline the LPS-stimulated expression of TLR4 messenger RNA regardless of environmental conditions. In contrast, LPS followed by hypoxia substantially increased apoptosis and cell death. In conclusion, protection from LPS-stimulated PAEC apoptosis by hypoxic preconditioning is attributable in part to reduction in TLR4 expression. If these signaling pathways apply to septic patients, they may account for differing sensitivities of individuals to acute lung injury depending on oxygen tensions in PAECs in vivo

An active K/Ka-band antenna array for the NASA ACTS mobile terminal

An active K/Ka-band antenna array is currently under development for NASA's ACTS Mobile Terminal (AMT). The AMT task will demonstrate voice, data, and video communications to and from the AMT vehicle in Los Angeles, California, and a base station in Cleveland, Ohio, via the ACTS satellite at 30 and 20 GHz. Satellite tracking for the land-mobile vehicular antenna system involves 'mechanical dithering' of the antenna, where the antenna radiates a fixed beam 46 deg. above the horizon. The antenna is to transmit horizontal polarization and receive vertical polarization at 29.634 plus or minus 0.15 GHz and 19.914 plus or minus 0.15 GHz, respectively. The active array will provide a minimum of 22 dBW EIRP transmit power density and a -8 dB/K deg. receive sensitivity

Landscape evolution at extensional relay zones

It is commonly argued that the extensional relay zones between adjacent crustal-scale normal fault segments are associated with large catchment-fan systems that deliver significant amounts of sediment to hanging wall basins. This conceptual model of extensional basin development, while useful, overlooks some of the physical constraints on catchment evolution and sediment supply in relay zones. We argue that a key factor in the geomorphic evolution of relay zones is the interplay between two different timescales, the time over which the fault array develops, and the time over which the footwall catchment-fan systems are established. Results of numerical experiments using a landscape evolution model suggest that, in isolated fault blocks, footwall catchment evolution is highly dependent on the pattern and rate of fault array growth. A rapidly linked en echelon fault geometry gives rise to capture of relay zone drainage by aggressive catchment incision in the relay zone and to consequent increases in the rate of sediment supply to the hanging wall. Capture events do not occur when the fault segments are allowed to propagate slowly toward an en echelon geometry. In neither case, however, are large relay zone catchment-fan systems developed. We propose several physical reasons for this, including geometric constraints and limits on catchment incision and sediment transport rates in relay zones. Future research efforts should focus on the timescales over which fault array development occurs, and on the quantitative variations in catchment-fan system morphology at relay zones

Rattus Model Utilizing Selective Pulmonary Ischemia Induces Bronchiolitis Obliterans Organizing Pneumonia

Bronchiolitis obliterans organizing pneumonia (BOOP), a morbid condition when associated with lung transplant and chronic lung disease, is believed to be a complication of ischemia. Our goal was to develop a simple and reliable model of lung ischemia in the Sprague-Dawley rat that would produce BOOP. Unilateral ischemia without airway occlusion was produced by an occlusive slipknot placed around the left main pulmonary artery. Studies were performed 7 days later. Relative pulmonary and systemic flow to each lung was measured by injection of technetium Tc 99m macroaggregated albumin. Histological sections were examined for structure and necrosis and scored for BOOP. Apoptosis was detected by immunohistochemistry with an antibody against cleaved caspase 3. Pulmonary artery blood flow to left lungs was less than 0.1% of the cardiac output, and bronchial artery circulation was ~2% of aortic artery flow. Histological sections from ischemic left lungs consistently showed Masson bodies, inflammation, and young fibroblasts filling the distal airways and alveoli, consistent with BOOP. In quantitative evaluation of BOOP using epithelial changes, inflammation and fibrosis were higher in ischemic left lungs than right or sham-operated left lungs. Apoptosis was increased in areas exhibiting histological BOOP, but there was no histological evidence of necrosis. Toll-like receptor 4 expression was increased in ischemic left lungs over right. An occlusive slipknot around the main left pulmonary artery in rats produces BOOP, providing direct evidence that ischemia without immunomodulation or coinfection is sufficient to initiate this injury. It also affords an excellent model to study signaling and genetic mechanisms underlying BOOP

Field Dependence of the Superconducting Basal Plane Anisotropy of TmNi2B2C

The superconductor TmNi2B2C possesses a significant four-fold basal plane anisotropy, leading to a square Vortex Lattice (VL) at intermediate fields. However, unlike other members of the borocarbide superconductors, the anisotropy in TmNi2B2C appears to decrease with increasing field, evident by a reentrance of the square VL phase. We have used Small Angle Neutron Scattering measurements of the VL to study the field dependence of the anisotropy. Our results provide a direct, quantitative measurement of the decreasing anisotropy. We attribute this reduction of the basal plane anisotropy to the strong Pauli paramagnetic effects observed in TmNi2B2C and the resulting expansion of vortex cores near Hc2.Comment: 8 pages, 6 figures, 1 tabl