Numerical calculations of the phase diagram of cubic blue phases in cholesteric liquid crystals

We study the static properties of cubic blue phases by numerically minimising the three-dimensional, Landau-de Gennes free energy for a cholesteric liquid crystal close to the isotropic-cholesteric phase transition. Thus we are able to refine the powerful but approximate, semi-analytic frameworks that have been used previously. We obtain the equilibrium phase diagram and discuss it in relation to previous results. We find that the value of the chirality above which blue phases appear is shifted by 20% (towards experimentally more accessible regions) with respect to previous estimates. We also find that the region of stability of the O5 structure -- which has not been observed experimentally -- shrinks, while that of BP I (O8-) increases thus giving the correct order of appearance of blue phases at small chirality. We also study the approach to equilibrium starting from the infinite chirality solutions and we find that in some cases the disclination network has to assemble during the equilibration. In these situations disclinations are formed via the merging of isolated aligned defects.Comment: 16 pages, 5 figures. Accepted for publication in Phys. Rev.

Extracting the Number of Short Range Correlated Nucleon Pairs from Inclusive Electron Scattering Data

The extraction of the relative abundances of short-range correlated (SRC) nucleon pairs from inclusive electron scattering is studied using the generalized contact formalism (GCF) with several nuclear interaction models. GCF calculations can reproduce the observed scaling of the cross-section ratios for nuclei relative to deuterium at high xB and large Q2, a2 = (σA/A)/(σd/2). In the nonrelativistic instant-form formulation, the calculation is very sensitive to the model parameters and only reproduces the data using parameters that are inconsistent with ab initio many-body calculations. Using a light-cone GCF formulation significantly decreases this sensitivity and improves the agreement with ab initio calculations. The ratio of similar mass isotopes, such as 40Ca and 48Ca, should be sensitive to the nuclear asymmetry dependence of SRCs, but is found to also be sensitive to low-energy nuclear structure. Thus the empirical association of SRC pair abundances with the measured a2 values is only accurate to about 20%. Improving this will require cross-section calculations that reproduce the data while properly accounting for both nuclear structure and relativistic effects

Extracing the number of short-range corerlated nucleon pairs from inclusive electron scattering data

The extraction of the relative abundances of short-range correlated (SRC) nucleon pairs from inclusive electron scattering is studied using the generalized contact formalism (GCF) with several nuclear interaction models. GCF calculations can reproduce the observed scaling of the cross-section ratios for nuclei relative to deuterium at high-$x_B$ and large-$Q^2$, $a_2=(\sigma_A/A)/(\sigma_d/2)$. In the non-relativistic instant-form formulation, the calculation is very sensitive to the model parameters and only reproduces the data using parameters that are inconsistent with ab-initio many-body calculations. Using a light-cone GCF formulation significantly decreases this sensitivity and improves the agreement with ab-initio calculations. The ratio of similar mass isotopes, such as $^{40}$Ca and $^{48}$Ca, should be sensitive to the nuclear asymmetry dependence of SRCs, but is found to also be sensitive to low-energy nuclear structure. Thus the empirical association of SRC pair abundances with the measured $a_2$ values is only accurate to about $20\%$. Improving this will require cross-section calculations that reproduce the data while properly accounting for both nuclear structure and relativistic effects.Comment: Accepted for publication in Phys. Rev. C (Lett). 6 pages, 4 figures, and online supplementary material

Reporting guidelines for clinical trials of artificial intelligence interventions: the SPIRIT-AI and CONSORT-AI guidelines

BACKGROUND: The application of artificial intelligence (AI) in healthcare is an area of immense interest. The high profile of 'AI in health' means that there are unusually strong drivers to accelerate the introduction and implementation of innovative AI interventions, which may not be supported by the available evidence, and for which the usual systems of appraisal may not yet be sufficient. MAIN TEXT: We are beginning to see the emergence of randomised clinical trials evaluating AI interventions in real-world settings. It is imperative that these studies are conducted and reported to the highest standards to enable effective evaluation because they will potentially be a key part of the evidence that is used when deciding whether an AI intervention is sufficiently safe and effective to be approved and commissioned. Minimum reporting guidelines for clinical trial protocols and reports have been instrumental in improving the quality of clinical trials and promoting completeness and transparency of reporting for the evaluation of new health interventions. The current guidelines-SPIRIT and CONSORT-are suited to traditional health interventions but research has revealed that they do not adequately address potential sources of bias specific to AI systems. Examples of elements that require specific reporting include algorithm version and the procedure for acquiring input data. In response, the SPIRIT-AI and CONSORT-AI guidelines were developed by a multidisciplinary group of international experts using a consensus building methodological process. The extensions include a number of new items that should be reported in addition to the core items. Each item, where possible, was informed by challenges identified in existing studies of AI systems in health settings. CONCLUSION: The SPIRIT-AI and CONSORT-AI guidelines provide the first international standards for clinical trials of AI systems. The guidelines are designed to ensure complete and transparent reporting of clinical trial protocols and reports involving AI interventions and have the potential to improve the quality of these clinical trials through improvements in their design and delivery. Their use will help to efficiently identify the safest and most effective AI interventions and commission them with confidence for the benefit of patients and the public

A = 3(e,e\u27) \u3csub\u3eB\u3c/sub\u3e ≥ 1 Cross-Section Ratios and the Isospin Structure of Short-Range Correlations

We study the relation between measured high-, high-2, helium-3 to tritium, (,′) inclusive-scattering cross-section ratios and the relative abundance of high-momentum neutron-proton (⁢) and proton-proton (⁢) short-range correlated nucleon pairs in three-body (=3) nuclei. Analysis of these data using a simple pair-counting cross-section model suggested a much smaller ⁢/⁢ ratio than previously measured in heavier nuclei, questioning our understanding of = 3 nuclei and, by extension, all other nuclei. Here, we examine this finding using spectral-function-based cross-section calculations, with both an ab initio = 3 spectral function and effective generalized contact formalism spectral functions using different nucleon-nucleon interaction models. The ab initio calculation agrees with the data, showing good understanding of the structure of = 3 nuclei. An 8% uncertainty on the simple pair-counting model, as implied by the difference between it and the ab initio calculation, gives a factor of 5 uncertainty in the extracted ⁢/⁢ ratio. Thus we see no evidence for the claimed “unexpected structure in the high-momentum wave function for hydrogen-3 and helium-3.

Equilibrium properties of a Josephson junction ladder with screening effects

In this paper we calculate the ground state phase diagram of a Josephson Junction ladder when screening field effects are taken into account. We study the ground state configuration as a function of the external field, the penetration depth and the anisotropy of the ladder, using different approximations to the calculation of the induced fields. A series of tongues, characterized by the vortex density $\omega$, is obtained. The vortex density of the ground state, as a function of the external field, is a Devil's staircase, with a plateau for every rational value of $\omega$. The width of each of these steps depends strongly on the approximation made when calculating the inductance effect: if the self-inductance matrix is considered, the $\omega=0$ phase tends to occupy all the diagram as the penetration depth decreases. If, instead, the whole inductance matrix is considered, the width of any step tends to a non-zero value in the limit of very low penetration depth. We have also analyzed the stability of some simple metastable phases: screening fields are shown to enlarge their stability range.Comment: 16 pp, RevTex. Figures available upon request at [email protected] To be published in Physical Review B (01-Dec-96

Phases of Josephson Junction Ladders

We study a Josephson junction ladder in a magnetic field in the absence of charging effects via a transfer matrix formalism. The eigenvalues of the transfer matrix are found numerically, giving a determination of the different phases of the ladder. The spatial periodicity of the ground state exhibits a devil's staircase as a function of the magnetic flux filling factor $f$. If the transverse Josephson coupling is varied a continuous superconducting-normal transition in the transverse direction is observed, analogous to the breakdown of the KAM trajectories in dynamical systems.Comment: 12 pages with 3 figures, REVTE

Evaluation of objective vitritis grading method using optical coherence tomography: influence of phakic status and previous vitrectomy

PURPOSE: To evaluate a proposed method for objective measurement of vitreous inflammation using a spectral. domain optical coherence tomography (SD OCT) device in a large cohort of uveitis eyes, including pseudophakic eyes and vitrectomized eyes. DESIGN: Retrospective, observational cohort study. METHODS: One hundred five uveitis eyes (105 patients) with different vitreous haze score grades according to standardized protocols and corresponding SD OCT images (Cirrus HD-OCT; Carl Zeiss Meditec, Dublin, California, USA) were included. Clinical data recorded included phakic status, previous vitreoretinal surgery, and anterior chamber (AC) cells and flare. SD OCT images were analyzed using custom software that provided absolute measurements of vitreous (VIT) and retinal pigment epithelium (RPE) signal intensities, which were compared to generate a relative optical density ratio with arbitrary units (VIT/RPE-relative intensity) and compared to VHS. RESULTS: VIT/RPE-relative intensity showed a significant positive correlation with vitreous haze score (r = 0.535, P <.001) that remained significant after adjusting for factors governing media clarity, such as AC cells, AC flare, and phakic status (R-2-adjusted = 0.424, P <.001). Significant differences were also observed between the different vitreous haze score groups (P <.001). Preliminary observation did not observe differences in VIT/RPE-relative intensity values between phakic and pseudophakic eyes (0.3522 vs 0.3577, P =.48) and between nonvitrectomized and vitrectomized eyes (0.3540 vs 0.3580, P = .52), overall and respectively for each vitreous haze score subgroup. CONCLUSIONS: VIT/RPE-relative intensity values provide objective measurements of vitreous inflammation employing an SD OCT device. Phakic status and previous vitrectomy su