Accurate Diagnosis of Colorectal Cancer Based On Histopathology Images Using Artificial Intelligence

Background: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is essential for CRC patients’ treatment. The current heavy workload of pathologists in clinics/hospitals may easily lead to unconscious misdiagnosis of CRC based on daily image analyses. Methods: Based on a state-of-the-art transfer-learned deep convolutional neural network in artificial intelligence (AI), we proposed a novel patch aggregation strategy for clinic CRC diagnosis using weakly labeled pathological whole-slide image (WSI) patches. This approach was trained and validated using an unprecedented and enormously large number of 170,099 patches, \u3e 14,680 WSIs, from \u3e 9631 subjects that covered diverse and representative clinical cases from multi-independent-sources across China, the USA, and Germany. Results: Our innovative AI tool consistently and nearly perfectly agreed with (average Kappa statistic 0.896) and even often better than most of the experienced expert pathologists when tested in diagnosing CRC WSIs from multicenters. The average area under the receiver operating characteristics curve (AUC) of AI was greater than that of the pathologists (0.988 vs 0.970) and achieved the best performance among the application of other AI methods to CRC diagnosis. Our AI-generated heatmap highlights the image regions of cancer tissue/cells. Conclusions: This first-ever generalizable AI system can handle large amounts of WSIs consistently and robustly without potential bias due to fatigue commonly experienced by clinical pathologists. It will drastically alleviate the heavy clinical burden of daily pathology diagnosis and improve the treatment for CRC patients. This tool is generalizable to other cancer diagnosis based on image recognition

Constraints on Spin-Independent Nucleus Scattering with sub-GeV Weakly Interacting Massive Particle Dark Matter from the CDEX-1B Experiment at the China Jin-Ping Laboratory

We report results on the searches of weakly interacting massive particles (WIMPs) with sub-GeV masses ($m_{\chi}$) via WIMP-nucleus spin-independent scattering with Migdal effect incorporated. Analysis on time-integrated (TI) and annual modulation (AM) effects on CDEX-1B data are performed, with 737.1 kg$\cdot$day exposure and 160 eVee threshold for TI analysis, and 1107.5 kg$\cdot$day exposure and 250 eVee threshold for AM analysis. The sensitive windows in $m_{\chi}$ are expanded by an order of magnitude to lower DM masses with Migdal effect incorporated. New limits on $\sigma_{\chi N}^{\rm SI}$ at 90\% confidence level are derived as $2\times$10$^{-32}\sim7\times$10$^{-35}$ $\rm cm^2$ for TI analysis at $m_{\chi}\sim$ 50$-$180 MeV/$c^2$, and $3\times$10$^{-32}\sim9\times$10$^{-38}$ $\rm cm^2$ for AM analysis at $m_{\chi}\sim$75 MeV/$c^2-$3.0 GeV/$c^2$.Comment: 5 pages, 4 figure

Measurement of the branching fractions of psi(2S) -> 3(pi+pi-) and J/psi -> 2(pi+pi-)

Using data samples collected at sqrt(s) = 3.686GeV and 3.650GeV by the BESII detector at the BEPC, the branching fraction of psi(2S) -> 3(pi+pi-) is measured to be [4.83 +- 0.38(stat) +- 0.69(syst)] x 10^-4, and the relative branching fraction of J/psi -> 2(pi+pi-) to that of J/psi -> mu+mu- is measured to be [5.86 +- 0.19(stat) +- 0.39(syst)]% via psi(2S) -> (pi+pi-)J/psi, J/psi -> 2(pi+pi-). The electromagnetic form factor of 3(pi+pi-) is determined to be 0.21 +- 0.02 and 0.20 +- 0.01 at sqrt(s) = 3.686GeV and 3.650GeV, respectively.Comment: 17pages, 7 figures, submitted to Phys. Rev.

Partial Wave Analysis of χc0→π+π−K+K−\chi_{c0}\to\pi^+\pi^-K^+K^-

A partial wave analysis of $\chi_{c0}\to\pi^+\pi^-K^+K^-$ in $\psi(2S)\to\gamma\chi_{c0}$ decay is presented using a sample of 14 million $\psi(2S)$ events accumulated by the BES II detector. The data are fitted to the sum of relativistic covariant tensor amplitudes for intermediate resonant decay modes. From the fit, significant contributions to $\chi_{c0}$ decays from the channels $f_0(980)f_0(980)$, $f_0(980)f_0(2200)$, $f_0(1370)f_0(1710)$, $K^*(892)^0\bar K^*(892)^0$, $K^*_0(1430)\bar K^*_0(1430)$, $K^*_0(1430)\bar K^*_2(1430) + c.c.$, and $K_1(1270)K$ are found. Flavor-SU(3)-violating $K_1(1270)-K_1(1400)$ asymmetry is observed. Values obtained for the masses and widths of the resonances $f_0(1710)$, $f_0(2200)$, $f_0(1370)$, and $K^*_0(1430)$ are presented.Comment: 16 pages, 9 figures, and 4 table

Search for psi(3770)\ra\rho\pi at the BESII detector at the Beijing Electron-Positron Collider

Non-$D\bar{D}$ decay \psppto \rhopi is searched for using a data sample of $(17.3\pm 0.5) pb^{-1}$ taken at the center-of-mass energy of 3.773 GeV by the BESII detector at the BEPC. No \rhopi signal is observed, and the upper limit of the cross section is measured to be \sigma(\EETO \rhopi)<6.0 pb at 90% C. L. Considering the interference between the continuum amplitude and the \pspp resonance amplitude, the branching fraction of \pspp decays to $\rho\pi$ is determined to be \BR(\pspp\ra\rho\pi)\in(6.0\times10^{-6}, 2.4\times10^{-3}) at 90% C. L. This is in agreement with the prediction of the $S$- and $D$-wave mixing scheme of the charmonium states for solving the ``\rhopi puzzle'' between \jpsi and \psp decays.Comment: 15 pages, 5 figure

A Unified Approach to the Classical Statistical Analysis of Small Signals

We give a classical confidence belt construction which unifies the treatment of upper confidence limits for null results and two-sided confidence intervals for non-null results. The unified treatment solves a problem (apparently not previously recognized) that the choice of upper limit or two-sided intervals leads to intervals which are not confidence intervals if the choice is based on the data. We apply the construction to two related problems which have recently been a battle-ground between classical and Bayesian statistics: Poisson processes with background, and Gaussian errors with a bounded physical region. In contrast with the usual classical construction for upper limits, our construction avoids unphysical confidence intervals. In contrast with some popular Bayesian intervals, our intervals eliminate conservatism (frequentist coverage greater than the stated confidence) in the Gaussian case and reduce it to a level dictated by discreteness in the Poisson case. We generalize the method in order to apply it to analysis of experiments searching for neutrino oscillations. We show that this technique both gives correct coverage and is powerful, while other classical techniques that have been used by neutrino oscillation search experiments fail one or both of these criteria.Comment: 40 pages, 15 figures. Changes 15-Dec-99 to agree more closely with published version. A few small changes, plus the two substantive changes we made in proof back in 1998: 1) The definition of "sensitivity" in Sec. V(C). It was inconsistent with our actual definition in Sec. VI. 2) "Note added in proof" at end of the Conclusio

Measurements of J/psi decays into phi pi^0, phi eta, and phi eta^prime

Based on 5.8x10^7 J/psi events detected in BESII, the branching fractions of J/psi--> phi eta and phi eta^prime are measured for different eta and eta^prime decay modes. The results are significantly higher than previous measurements. An upper limit on B(J/psi--> phi pi^0) is also obtained.Comment: 9 pages, 10 figure

Observation of p pbar pi^0 and p pbar eta in psi' decays

The processes psi'-->p pbar pi^0 and psi'-->p pbar eta are studied using a sample of 14 million psi' decays collected with the Beijing Spectrometer at the Beijing Electron-Positron Collider. The branching fraction of psi'-->p pbar pi^0 is measured with improved precision as (13.2\pm 1.0\pm 1.5)\times 10^{-5}, and psi'-->p pbar eta is observed for the first time with a branching fraction of (5.8\pm 1.1\pm 0.7)\times 10^{-5}, where the first errors are statistical and the second ones are systematic.Comment: 15 pages, 8 figures and 3 table

Measurement of the chi_{c2} Polarization in psi(2S) to gamma chi_{c2}

The polarization of the chi_{c2} produced in psi(2S) decays into gamma chi_{c2} is measured using a sample of 14*10^6 psi(2S) events collected by BESII at the BEPC. A fit to the chi_{c2} production and decay angular distributions in psi(2S) to gamma chi_{c2}, chi_{c2} to pi pi and KK yields values x=A_1/A_0=2.08+/-0.44 and y=A_2/A_0=3.03 +/-0.66, with a correlation rho=0.92 between them, where A_{0,1,2} are the chi_{c2} helicity amplitudes. The measurement agrees with a pure E1 transition, and M2 and E3 contributions do not differ significantly from zero.Comment: 6 pages, 4 figures, 1 tabl