19 research outputs found
Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance
Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR
Consistency of shared reference frames should be reexamined
In a recent Letter [G. Chiribella et al., Phys. Rev. Lett. 98, 120501
(2007)], four protocols were proposed to secretly transmit a reference frame.
Here We point out that in these protocols an eavesdropper can change the
transmitted reference frame without being detected, which means the consistency
of the shared reference frames should be reexamined. The way to check the above
consistency is discussed. It is shown that this problem is quite different from
that in previous protocols of quantum cryptography.Comment: 3 pages, 1 figure, comments are welcom
Application of microfluidic chips in anticancer drug screening
With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects, and drug cytotoxicity.Peer reviewe