口服雄黄治疗骨髓增生异常综合征概况

Chinese arsenic drugs have been applied in Chinese medicine for several centuries. Active ingredients of realgar is As2S2. Oral realgar has been widely used in the treatment of myelodysplastic syndrome (MDS) with obvious Chinese characteristics, and the good clinical outcomes have been achieved. Decreasing the gastrointestinal adverse reactions of realgar can not only increase tolerance of patient to realgar, but improve the clinical efficacy, which will ensure the safety of oral realgar for clinical use, as well as open a new vision for the treatment of MDS.含砷中药在祖国传统医学中有悠久的历史。雄黄的活性成分是二硫化二砷（As2S2）。口服雄黄在骨髓增生异常综合征（MDS）的临床治疗中越来越广泛，具有明显的中医特色，也取得了很好的临床效果。控制雄黄的消化道不良反应，不仅增加患者对口服雄黄的耐受性，而且可以提高临床疗效，为口服雄黄的临床应用提供了安全性，也为MDS的治疗领域开辟了新途径

Preliminary study on the immunology pathogenesis of ocular myasthenia gravis in children

AIM: To discuss the role of humoral immunity and cellular immunity in the development of ocular myasthenia gravis in children by analyzing the clinical value of the indices including immunoglobulin, complement and T cell subgroup in peripheral blood. <p>METHODS: The concentrations of serum IgG, IgA, IgM, C3 and C4 in the myasthenia gravis group and the control group were detected by immune compare turbid. The contents of CD3⁺T cell, CD4⁺T cell and CD8⁺T cell were detected by flow cytometry. Data was analyzed by Independent-Sample Test.<p>RESULTS: There were no significant differences in contents of IgA, IgM, CD3⁺T cell, CD8⁺T cell between ocular myasthenia gravis group in children and the control group(<i>P</i>>0.05). The concentrations of serum IgG, C3 and C4 for myasthenia gravis group were lower than those of the control group(<i>P</i><0.05). The content of CD4⁺T cell were higher than those of the control group(<i>P</i><0.05).<p>CONCLUSION: Complement C3, C4 and CD4⁺T cell played an important role in immunology pathogenesis mechanism for ocular myasthenia gravis in children

Comprehensive Analysis and Functional Studies of WRKY Transcription Factors in Nelumbo nucifera

The WRKY family is one of the largest transcription factor (TF) families in plants and plays central roles in modulating plant stress responses and developmental processes, as well as secondary metabolic regulations. Lotus (Nelumbo nucifera) is an aquatic crop that has significant food, ornamental and pharmacological values. Here, we performed an overview analysis of WRKY TF family members in lotus, and studied their functions in environmental adaptation and regulation of lotus benzylisoquinoline alkaloid (BIA) biosynthesis. A total of 65 WRKY genes were identified in the lotus genome and they were well clustered in a similar pattern with their Arabidopsis homologs in seven groups (designated I, IIa-IIe, and III), although no lotus WRKY was clustered in the group IIIa. Most lotus WRKYs were functionally paired, which was attributed to the recently occurred whole genome duplication in lotus. In addition, lotus WRKYs were regulated dramatically by salicilic acid (SA), jasmonic acid (JA), and submergence treatments, and two lotus WRKYs, NnWRKY40a and NnWRKY40b, were significantly induced by JA and promoted lotus BIA biosynthesis through activating BIA biosynthetic genes. The investigation of WRKY TFs for this basal eudicot reveals new insights into the evolution of the WRKY family, and provides fundamental information for their functional studies and lotus breeding

Modulation of chiral anomaly and bilinear magnetoconductivity in Weyl semimetals by impurity-resonance states

The phenomenon of nonlinear transport has attracted tremendous interest within the condensed matter community. We present a theoretical framework for nonlinear transport based on the nonequilibrium retarded Green's function, and examine the impact of disorder on nonlinear magnetotransport in Weyl semimetals (WSMs). It is demonstrated that bilinear magnetoconductivity can be induced in disordered WSMs by several mechanisms, including impurity-induced tilting of the Weyl cones, Lorentz-force-induced normal orbital magnetic moment, and chiral anomaly arising from the Berry-curvature-induced anomalous orbital magnetic moment. Additionally, we observe that the localization of Weyl fermions by impurity scattering will lead to resonant dips in both the chiral chemical potential and magnetoconductivity when the Fermi energy approaches the impurity resonance states. Our findings offer a theoretical proposition for modulating nonreciprocal transport in topological semimetals.Comment: 5 figure

Auxin response factor 6A regulates photosynthesis, sugar accumulation, and fruit development in tomato.

Auxin response factors (ARFs) are involved in auxin-mediated transcriptional regulation in plants. In this study, we performed functional characterization of SlARF6A in tomato. SlARF6A is located in the nucleus and exhibits transcriptional activator activity. Overexpression of SlARF6A increased chlorophyll contents in the fruits and leaves of tomato plants, whereas downregulation of SlARF6A decreased chlorophyll contents compared with those of wild-type (WT) plants. Analysis of chloroplasts using transmission electron microscopy indicated increased sizes of chloroplasts in SlARF6A-overexpressing plants and decreased numbers of chloroplasts in SlARF6A-downregulated plants. Overexpression of SlARF6A increased the photosynthesis rate and accumulation of starch and soluble sugars, whereas knockdown of SlARF6A resulted in opposite phenotypes in tomato leaves and fruits. RNA-sequence analysis showed that regulation of SlARF6A expression altered the expression of genes involved in chlorophyll metabolism, photosynthesis and sugar metabolism. SlARF6A directly bound to the promoters of SlGLK1, CAB, and RbcS genes and positively regulated the expression of these genes. Overexpression of SlARF6A also inhibited fruit ripening and ethylene production, whereas downregulation of SlARF6A increased fruit ripening and ethylene production. SlARF6A directly bound to the SAMS1 promoter and negatively regulated SAMS1 expression. Taken together, these results expand our understanding of ARFs with regard to photosynthesis, sugar accumulation and fruit development and provide a potential target for genetic engineering to improve fruit nutrition in horticulture crops