Solving ill-posed bilevel programs

This paper deals with ill-posed bilevel programs, i.e., problems admitting multiple lower-level solutions for some upper-level parameters. Many publications have been devoted to the standard optimistic case of this problem, where the difficulty is essentially moved from the objective function to the feasible set. This new problem is simpler but there is no guaranty to obtain local optimal solutions for the original optimistic problem by this process. Considering the intrinsic non-convexity of bilevel programs, computing local optimal solutions is the best one can hope to get in most cases. To achieve this goal, we start by establishing an equivalence between the original optimistic problem an a certain set-valued optimization problem. Next, we develop optimality conditions for the latter problem and show that they generalize all the results currently known in the literature on optimistic bilevel optimization. Our approach is then extended to multiobjective bilevel optimization, and completely new results are derived for problems with vector-valued upper- and lower-level objective functions. Numerical implementations of the results of this paper are provided on some examples, in order to demonstrate how the original optimistic problem can be solved in practice, by means of a special set-valued optimization problem

KKT reformulation and necessary conditions for optimality in nonsmooth bilevel optimization

For a long time, the bilevel programming problem has essentially been considered as a special case of mathematical programs with equilibrium constraints (MPECs), in particular when the so-called KKT reformulation is in question. Recently though, this widespread believe was shown to be false in general. In this paper, other aspects of the difference between both problems are revealed as we consider the KKT approach for the nonsmooth bilevel program. It turns out that the new inclusion (constraint) which appears as a consequence of the partial subdifferential of the lower-level Lagrangian (PSLLL) places the KKT reformulation of the nonsmooth bilevel program in a new class of mathematical program with both set-valued and complementarity constraints. While highlighting some new features of this problem, we attempt here to establish close links with the standard optimistic bilevel program. Moreover, we discuss possible natural extensions for C-, M-, and S-stationarity concepts. Most of the results rely on a coderivative estimate for the PSLLL that we also provide in this paper

The generalized Mangasarian-Fromowitz constraint qualification and optimality conditions for bilevel programs

We consider the optimal value reformulation of the bilevel programming problem. It is shown that the Mangasarian-Fromowitz constraint qualification in terms of the basic generalized differentiation constructions of Mordukhovich, which is weaker than the one in terms of Clarke’s nonsmooth tools, fails without any restrictive assumption. Some weakened forms of this constraint qualification are then suggested, in order to derive Karush-Kuhn-Tucker type optimality conditions for the aforementioned problem. Considering the partial calmness, a new characterization is suggested and the link with the previous constraint qualifications is analyzed

Variational Analysis in Bilevel Programming

The paper is devoted to applications of advanced tools of modern variational analysis and generalized differentiation to problems of optimistic bilevel programming. In this way, new necessary optimality conditions are derived for two major classes of bilevel programs: those with partially convex and with fully convex lower-level problems. We provide detailed discussions of the results obtained and their relationships with known results in this area

Curcumin: Zelluläre Verteilung, Metabolismus und toxische Effekte

Den sekundären Inhaltsstoffen der Curcuma-Pflanze, den Curcuminoiden, werden viele gesundheitsfördernde Wirkungen zugeschrieben. Daher wurde in dieser Arbeit der Einfluss von Curcumin auf die Morphologie und die zellulären Wirkungen von kultivierten Zellen bestimmt. Zudem wurde die Aufnahme und Akkumulation von Curcumin in diesen Zellen aufgeklärt. Weiterhin wurde die Resorption von Curcumin im etablierten Caco-2 Millicell® System und dessen Metabolisierung durch humane Darmbakterien untersucht

Tropical analogues of a Dempe-Franke bilevel optimization problem

We consider the tropical analogues of a particular bilevel optimization problem studied by Dempe and Franke and suggest some methods of solving these new tropical bilevel optimization problems. In particular, it is found that the algorithm developed by Dempe and Franke can be formulated and its validity can be proved in a more general setting, which includes the tropical bilevel optimization problems in question. We also show how the feasible set can be decomposed into a finite number of tropical polyhedra, to which the tropical linear programming solvers can be applied.Comment: 11 pages, 1 figur