310 research outputs found
Aproximación lineal por tramos a comportamientos no lineales: estimación de señales de nivel de crecimiento
En este trabajo se propone una señal del nivel y del crecimiento tendencial de una variable económica, cuando ésta ha pasado por un período temporal específico en que determinados aconteeimientos especiales
han truncado su tendencia. Para ello se analizan las consecuencias de emplear modelos univariantes no lineales, así como análisis de intervención. En el supuesto de ruptura estocástica, una alternativa
a modelos no lineales se obtiene con modelos lineales para cada tramo, modificando así las condiciones iniciales del esquema en diferencias finitas estocásticas que regula la generación del proceso a partir del punto de ruptura. EI procedimiento propuesto, que precisa dispaner de un cierto número de observaciones tras el momento de ruptura, permite obtener la evolución subyacente de una serie en el entorno del período temporal específico evitando los inconveníentes
de los procedimientos anteriores. Con el objeto de desarrollar esta idea, el trabajo analiza la seríe de importaciones no energóticas.Publicad
The future of AD clinical trials with the advent of anti-amyloid therapies: An CTAD Task Force report
BACKGROUND: Aducanumab (ADUHELMTM) was approved for the treatment of Alzheimer\u27s disease (AD) in the US. This approval was supported by an effect on the cerebral amyloid plaque load and evidence of cognitive efficacy to be confirmed in post-marketing trials. Other anti-amyloid antibodies are under investigation in phase III (donanemab, lecanemab, gantenerumab) and have shown preliminary evidence of a cognitive benefit in phase II trials. Although these agents target a small segment of patients with mild cognitive impairment due to AD or mild AD dementia, their advent will change the design of future clinical trials both for anti-amyloid and non-amyloid drugs. These changes will promote the selection of patients in clinical trials by amyloid and tau biomarkers that identify patients with appropriate biology and may follow the treatment response to approved amyloid antibodies. The use of these agents creates the opportunity to test combined drug therapies and to conduct comparative assessments with innovative therapies and newly approved drugs available in clinical practice. Blood-based AD biomarkers should be implemented in research and could facilitate the recruitment into clinical trials. Anti-amyloid antibodies will have positive (e.g., more early diagnosis) and negative impacts (some subjects will be reluctant to participate in trials and risk assignment to placebo) on AD trials in the immediate future. We present the results of the CTAD Task Force on this topic, in Boston, November 6, 2021
Domain walls at the spin density wave endpoint of the organic superconductor (TMTSF)2PF6 under pressure
We report the first comprehensive investigation of the organic superconductor
(TMTSF)2PF6 in the vicinity of the endpoint of the spin density wave - metal
phase transition where phase coexistence occurs. At low temperature, the
transition of metallic domains towards superconductivity is used to reveal the
various textures. In particular, we demonstrate experimentally the existence of
1D and 2D metallic domains with a cross-over from a filamentary
superconductivity mostly along the c?-axis to a 2D superconductivity in the
b?c-plane perpendicular to the most conducting direction. The formation of
these domain walls may be related to the proposal of a soliton phase in the
vicinity of the critical pressure of the (TMTSF)2PF6 phase diagram.Comment: 5 page
Thermodynamics and magnetic field profiles in low-kappa type-II superconductors
Two-dimensional low-kappa type-II superconductors are studied numerically
within the Eilenberger equations of superconductivity. Depending on the
Ginzburg-Landau parameter \kappa=\lambda/\xi vortex-vortex interaction can be
attractive or purely repulsive. The sign of interaction is manifested as a
first (second) order phase transition from Meissner to the mixed state.
Temperature and field dependence of the magnetic field distribution in
low-kappa type-II superconductors with attractive intervortex interaction is
calculated. Theoretical results are compared to the experiment.Comment: 4 pages, 3 figure
Role of Phase Variables in Quarter-Filled Spin Density Wave States
Several kinds of spin density wave (SDW) states with both quarter-filled band
and dimerization are reexamined for a one-dimensional system with on-site,
nearest-neighbor and next-nearest-neighbor repulsive interactions, which has
been investigated by Kobayashi et al. (J. Phys. Soc. Jpn. 67 (1998) 1098).
Within the mean-field theory, the ground state and the response to the density
variation are calculated in terms of phase variables, and ,
where expresses the charge fluctuation of SDW and describes the
relative motion between density wave with up spin and that with down spin
respectively. It is shown that the exotic state of coexistence of 2k_F-SDW and
2k_F-charge density wave (CDW) is followed by 4k_F-SDW but not by 4k_F-CDW
where k_F denotes a Fermi wave vector. The harmonic potential with respect to
the variation of and/or disappears for the interactions, which
lead to the boundary between the pure 2k_F-SDW state and the corresponding
coexistent state.Comment: 9 pages, 15 figures, to be published in J. Phys. Soc. Jpn. 69 No.3
(2000) 79
Spin-density wave versus superconducting fluctuations for quasi-one-dimensional electrons in two chains of Tomonaga-Luttinger liquids
We study possible states at low temperatures by applying the
renormalization-group method to two chains of Tomonaga-Luttinger liquids with
both repulsive intrachain interactions and interchain hopping. As the energy
decreases below the hopping energy, three distinct regions I, III, and II
appear successively depending on properties of fluctuations. The crossover from
the spin-density wave (SDW) state to superconducting (SC) state takes place in
region III where there are the excitation gaps of transverse charge and spin
fluctuations. The competition between SDW and SC states in region III is
crucial to understanding the phase diagram in the quasi-one-dimensional organic
conductors.Comment: 11 pages, Revtex format, 1 figure, to be published in Phys. Rev.
Spin-triplet superconductivity in quasi-one dimension
We consider a system with electron-phonon interaction, antiferromagnetic
fluctuations and disconnected open Fermi surfaces. The existence of odd-parity
superconductivity in this circumstance is shown for the first time. If it is
applied to the quasi-one-dimensional systems like the organic conductors
(TMTSF)_2X we obtain spin-triplet superconductivity with nodeless gap. Our
result is also valid in higher dimensions(2d and 3d).Comment: 2 page
Antiferromagnetic Phases of One-Dimensional Quarter-Filled Organic Conductors
The magnetic structure of antiferromagnetically ordered phases of
quasi-one-dimensional organic conductors is studied theoretically at absolute
zero based on the mean field approximation to the quarter-filled band with
on-site and nearest-neighbor Coulomb interaction. The differences in magnetic
properties between the antiferromagnetic phase of (TMTTF)X and the spin
density wave phase in (TMTSF)X are seen to be due to a varying degrees of
roles played by the on-site Coulomb interaction. The nearest-neighbor Coulomb
interaction introduces charge disproportionation, which has the same spatial
periodicity as the Wigner crystal, accompanied by a modified antiferromagnetic
phase. This is in accordance with the results of experiments on (TMTTF)Br
and (TMTTF)SCN. Moreover, the antiferromagnetic phase of (DI-DCNQI)Ag
is predicted to have a similar antiferromagnetic spin structure.Comment: 8 pages, LaTeX, 4 figures, uses jpsj.sty, to be published in J. Phys.
Soc. Jpn. 66 No. 5 (1997
The High Magnetic Field Phase Diagram of a Quasi-One Dimensional Metal
We present a unique high magnetic field phase of the quasi-one dimensional
organic conductor (TMTSF)ClO. This phase, termed "Q-ClO", is
obtained by rapid thermal quenching to avoid ordering of the ClO anion. The
magnetic field dependent phase of Q-ClO is distinctly different from that
in the extensively studied annealed material. Q-ClO exhibits a spin density
wave (SDW) transition at 5 K which is strongly magnetic field
dependent. This dependence is well described by the theoretical treatment of
Bjelis and Maki. We show that Q-ClO provides a new B-T phase diagram in the
hierarchy of low-dimensional organic metals (one-dimensional towards
two-dimensional), and describe the temperature dependence of the of the quantum
oscillations observed in the SDW phase.Comment: 10 pages, 4 figures, preprin
Pu Coexists in Three Oxidation States in a Borosilicate Glass: Implications for Pu Solubility
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