One-step synthesis of silver nanostructures using Heracleum persicum fruit extract, their cytotoxic activity, anti-cancer and anti-oxidant activities

Bio-inspired techniques are used for synthesis in terms of application, green chemical research, facile, and eco-friendly chemistry study of silver nanostructures utilizing plant extracts as natural reducing/stabilization and solid adjuvants without the use of toxic and damaging reagents. The present study investigates the biosynthesis of Ag nanoparticles via the mediation of the methanolic extract of Heracleum persicum seeds, without utilizing any stabilizer or surfactant. These nanostructures were identified utilizing ultraviolet-visible spectroscopy, field emission scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, high-resolution transmission electron microscopy, Fourier-transform infrared spectroscopy and dynamic light scattering. The attributes of AgNPs versus usual human breast adenocarcinoma cell lines that is, Hs 281.T, MDA-MB-468, AU565 AU-565, MCF7, CAMA-1, SK-BR-3, NMU, and RBA were evaluated. The livability of breast adenocarcinoma cell line diminishes dose-dependently in the existence of AgNPs. After clinical studies, AgNPs can be used as a green drug in the treatment of human breast adenocarcinoma

Phytochemical constituents, antioxidant activity and toxicity potential of Phlomis olivieri Benth

Abstract Background and objectives: Phlomis olivieri Benth. (Lamiaceae) is a medicinal plant widely distributed in Iran. In the present study, we have investigated the phytochemical constituents, antioxidant activity and general toxicity potential of the aerial parts of this species. Methods: Silica gel (normal and reversed phases) and Sephadex LH-20 column chromatographies were used for isolation of compounds from methanol-soluble portion (MSP) of the total extract obtained from P. olivieri aerial parts. The structures of isolated compounds were elucidated usin

Pyrrolizidine alkaloids from Heliotropium transoxanum Bunge

Background and objectives: The plants belonging to the genus Heliotropium L. (Boraginaceae) are the main sources of toxic pyrrolizidine alkaloids (PAs). In the present study, we have investigated the PAs of the aerial parts of Heliotropium transoxanum Bunge, a perennial species native to Iran. Methods: Silica gel column chromatography and silica gel PTLC were applied for the isolation of PAs present in the total methanol extract of H. transoxanum. The structures of the isolated compounds were identified using 1H-NMR, 13C-NMR and EIMS spectral analyses. Results: Three PAs, heliotrine (1), lasiocarpine (2) and heliotrine N-oxide (3),with known mutagenic and genotoxic properties, were isolated from the aerial parts of H. transoxanum. Conclusion: The results of this study on the presence of toxic PAs in H. transoxanum introduce this herb as a poisonous species and also suggest it as an appropriate source for the isolation of heliotrine and lasiocarpine for further toxicological and pharmacological studies

Composition and biological activities of the essential oil from a Sicilian accession of Prangos ferulacea (L.) Lindl.

Prangos ferulacea (L.) Lindl. (Fam. Apiaceae), is an orophilous species of eastern worthy of exploitation in different fields. With the aim to provide new insights into the Mediterranean and western Asia which possesses several biological properties, which are worthy of exploitation in different fields. With the aim to provide new insights into the phytochemistry and pharmacology of this species, a local accession growing in Sicily (South Italy) was investigated as well. Notably, the P. ferulacea essential oil chemical composition and the antioxidant, anti-acetylcholinesterase (AChE) and cytotoxic activities have been studied. This analysis allowed to identify a new chemotype and to report good biological results for this oil