Omega-3 for Inflammatory Bowel Disease: Is it worthy?- A Literature Review

Tujuan: Memberikan pemahaman mengenai potensi terapeutik asam lemak omega-3 dalam penanganan Inflammatory Bowel Disease (IBD). Metode: Artikel ini disusun berdasarkan metode tinjauan literatur. Sumber data diperoleh dari artikel-artikel ilmiah yang dipublikasikan di jurnal internasional berbahasa Inggris. Proses pencarian literatur dilakukan melalui mesin pencari Google Scholar dan PubMed. Hasil: Inflammatory Bowel Disease (IBD), yang mencakup kondisi seperti Ulcerative Colitis (UC) dan Crohn's Disease (CD), merupakan kelompok gangguan inflamasi kronis yang mempengaruhi saluran pencernaan. Dalam beberapa tahun terakhir, asam lemak omega-3 telah menjadi titik perhatian dalam diskusi IBD, terutama karena sifat anti-inflamasinya. Penelitian epidemiologi menunjukkan bahwa diet kaya omega-3 dapat meningkatkan kemungkinan remisi klinis pada pasien IBD. Sebagai contoh, pasien UC yang mengonsumsi salmon Alaskan dalam jumlah tinggi menunjukkan penurunan marker inflamasi dibandingkan dengan kelompok kontrol. Kesimpulan: Bukti saat ini menunjukkan bahwa makanan alami yang kaya omega-3, seperti salmon, memiliki potensi manfaat dalam penanganan Inflammatory Bowel Disease

Unlocking the Fiber Mystery: The Secret Key to Blood Sugar Control and Diabetes Management

Serat makanan terdiri dari karbohidrat kompleks dan lignin yang tidak dihidrolisis oleh enzim manusia dan, oleh karena itu, tidak dicerna atau diserap oleh tubuh manusia. Berbagai efek serat makanan, termasuk peningkatan viskositas intraluminal, penurunan penyerapan makronutrien, dan berkurangnya sekresi insulin, berkontribusi pada pengendalian glikemia postprandial dan mengurangi risiko hipoglikemia pasca-penyerapan. Tujuan: Untuk memberikan pemahaman bahwa asupan serat makanan yang cukup sangat penting untuk kontrol glikemik dan manajemen diabetes yang efektif. Metode: Artikel ini disusun berdasarkan metode tinjauan pustaka. Hasil: Serat makanan memainkan peran penting dalam kontrol glukosa darah, terutama pada individu dengan pra-diabetes dan diabetes. Efek intrinsik serat makanan dalam mengurangi asupan energi dan mempromosikan penurunan berat badan juga penting dalam manajemen diabetes. Selain itu, efek usus besar dari serat makanan, yang meningkatkan fermentasi asam lemak rantai pendek dan mengurangi glukosa harian dan produksi asam lemak bebas, dapat meningkatkan sensitivitas insulin dan mengurangi sekresi insulin. Kesimpulan: Serat pangan memiliki manfaat untuk mengontrol glukosa darah

ANALISIS PENERAPAN SISTEM AKUNTANSI INSTANSI BERBASIS AKRUAL BERDASARKAN PP NOMOR 71 TAHUN 2010 DALAM PENYUSUNAN LAPORAN KEUANGAN (Studi Kasus di Pengadilan Militer III-15 Kupang)

Penelitian ini bertujuan untuk mengetahui penerapan Sistem Akuntansi Instansi Berbasis Akrual (SAIBA) berdasarkan PP Nomor 71 tahun 2010 dalam penyusunan laporan keuangan di Kantor Pengadilan Militer III-15 Kupang. Jenis penelitian ini adalah penelitian kualitatif. Data dalam penelitian ini dikumpulkan melalui observasi, wawancara langsung dan dokumentasi. Metode analisis data yang digunakan adalah deskriptif kualitatif antara lain dengan mereduksi data yaitu merangkum dan memilih hal-hal pokok, fokus pada hal-hal penting yang diperoleh peneliti dari lapangan. Kemudian data disajikan untuk memudahkan melihat gambaran penelitian dan menarik kesimpulan atas analisis yang telah dilakukan. Hasil penelitian menunjukan bahwa Penerapan Sistem Akuntansi Berbasis Akrual pada Pengadilan Militer III-15  telah dilaksanakan berdasarkan PP Nomor 71 tahun 2010 tentang Standar Akuntansi Pemerintah dengan digunakannya aplikasi SAIBA dalam penyusunan laporan keuangan. Laporan keuangan yang dihasilkan melalui Aplikasi Sistem Akuntansi Instansi Berbasis Akrual (SAIBA) yaitu Laporan Realisasi Anggaran, Neraca, laporan operasional, dan Laporan perubahan ekuitas. Sedangkan untuk Catatan atas Laporan Keuangan disusun tersendiri setelah proses penyusunan laporan keuangan di aplikasi Sistem Akuntansi Instansi Berbasis Akrual (SAIBA) selesai dan dapat dipertangungjawabkan. Namun seringnya update pada aplikasi Sistem Akuntansi Instansi Berbasis Akrual (SAIBA) dan proses rekonsiliasi yang lama menjadi penyebab keterlambatan penyampaian laporan keuangan pada Pengadilan Militer III-15 Kupang. Laporan keuangan Pengadilan Militer III-15 Kupang yang dihasilkan dari aplikasi SAIBA telah memenuhi unsur dan syarat karakteristik kualitatif laporan keuangan yang meliputi relevan, andal, dapat dibandingkan, dan dapat dipahami sebagaimana yang dinyatakan dalam PP Nomor 71 tahun 2010 tentang Standar Akuntansi Pemerintah

Diet Rendah Protein pada Gagal Ginjal Kronik

Tujuan: Menyediakan informasi mengenai diet rendah protein pada gagal ginjal kronik. Metode: Penulisan artikel ini menggunakan metode literature review. Sumber yang dipakai berupa artikel dari jurnal internasional. Artikel diambil dalam menggunakan Bahasa Inggris. Pencarian sumber artikel menggunakan bantuan mesin pencari Google Scholar dan PubMed. Hasil: Diet rendah protein (Low Protein Diet/LPD, 0,6-0,8 g/kg/hari) dan bahkan diet protein sangat rendah (Very-Low Protein Diet/vLPD, 0,3-0,4 g/kg/hari) direkomendasikan untuk pasien CKD. Diet rendah protein (Low Protein Diet/LPD) memiliki banyak keunggulan dalam pengelolaan pasien CKD dengan mengurangi produk limbah nitrogen dan mengurangi beban kerja ginjal melalui penurunan tekanan intraglomerular, yang memiliki efek protektif ginjal, terutama pada mereka yang memiliki cadangan fungsi nefron yang berkurang. Kesimpulan: Pengelolaan pasien Chronic Kidney Disease (CKD) dengan diet protein rendah (LPD) telah diidentifikasi sebagai strategi potensial untuk mengendalikan gejala uremik dan komplikasi metabolik, serta menunda kebutuhan untuk dialisis. Meskipun memiliki manfaat potensial, keberatan terkait Protein-Energy Wasting (PEW) telah membatasi adopsi luas strategi ini di kalangan klinisi. Penting untuk menekankan bahwa penerapan LPD memerlukan pemantauan gizi yang ketat. Sebuah pendekatan multidisiplin, melibatkan spesialis seperti dokter, perawat, ahli gizi, dan pekerja sosial, diperlukan untuk memastikan keberhasilan dan keamanan penerapan LPD dalam pengelolaan pasien CKD

HUBUNGAN KADAR MAGNESIUM DALAM ASI DAN ASUPAN ENERGI IBU DENGAN PENAMBAHAN BERAT BADAN BAYI USIA 0-6 BULAN DIPUSKESMAS LUBUK BUAYA PADANG

Metode penelitian ini adalah cross sectional study. Responden penelitian adalah 44 orang ibu yang mempunyai bayi usia 0-6 bulan yang menyusui secara ekslusif di Puskesmas Lubuk Buaya Padang yang masuk kriteria inklusi dan ekslusi. Kadar magnesium dalam ASI diperiksa di Balai Laboratorium Kesehatan (BLK) Kota Padang. Asupan energi ibu di dapatkan melalui wawancara dengan menggunakan Semi QuantitativeFood Frequency Questionare (SQ-FFQ).Data dianalisis dengan menggunakan uji korelasi pearson. Hasil penelitian didapatkan rata-rata kadar magnesium dalam ASI adalah 4,8 mg/dl ± SD dan rata-rata asupan energi ibu 2196,6 KKal/hari ± SD. Terdapat hubungan yang signifikan kadar magnesium dalam ASI dengan penambahan berat badan bayi (p=0,04), dan terdapat hubungan yang signifikan asupan energi ibu dengan penambahan berat badan bayi (p=0,014

Analysis of Factors Related to the Incidence of Stunting in Fishermen's Children Aged 12-24 Months

Stunting is a condition of growth failure in a child's body length of less than -2 standard deviations based on World Health Organization, standards due to manifestations of long-term malnutrition, recurrent infectious diseases, and inadequate psychosocial stimulation. The research aims to determine the analysis of factors related to the incidence of stunting in children aged 12-24 months in the Air Bangis Health Center working area in 2020. The research is a Mix Method Study with a Sequential Explanatory design carried out in the Air Bangis Health Center Working Area in 2022. This research was conducted in the Air Bangis Health Center Work Area from November to February 2023. The research quantitatively conducted a Cross-Sectional Study on children aged 12-24 months, as many as 148 people and their mothers. Measurement of body length according to age, questionnaires for quantitative data, and in-depth interviews for qualitative data. The logistic regression test determines the most dominant variable that causes stunting. There is a significant relationship between food intake (p-value=0.042), sanitation (p-value=0.013), immunization status (p-value=0.117), and maternal education (p-value=0.095) on the incidence of stunting. There is no relationship between exclusive breastfeeding, infectious diseases, hygiene and family income. The most dominant factor is food intake, with value (POR=2.220). Based on the research results, it was found that the most dominant variable was food intake. It is recommended for mothers of toddlers to pay more attention to nutritional intake during pregnancy and breastfeeding and it is recommended for health workers to provide education in the form of health education about nutritious foods to prospective pregnant mothers to pay more attention to their nutritional intake. Keywords: Intake, Nutrition, Sanitation, Stuntin

Role of TERT Gene in Relationship between Body Fat Percentage with the Modifiable Risk Factors of Cardiometabolic Disease in Minangkabau Premenopausal

Background: Cardiometabolic disease risk is increasing in the premenopausal phase of women life. This study aims to relationship body fat percentage with the modifiable risk factors of cardiometabolic disease in Minangkabau premenopausal people. Methods: A cross-sectional study was conducted in 111 Minangkabau premenopausal people, aged 40 – 55 years old at Padang City in West Sumatera, Indonesia. Body fat percentage analyzed by Bioelectrical Impedance Analyzer (BIA). Fasting blood glucose and lipid profile was examined from venous blood. Data were analyzed by using a Rank-Spearman correlation test with significant levels p<0.05. Results:Average body fat percentage of subjects 36.23 ± 6.9, fasting blood glucose 101.52 ± 12.3 mg/dL; total cholesterol 193.99±41.5 mg/dL; triglyceride 113.76±37.9 mg/dL mg/dL; LDL-cholesterol 120.59±45.7 mg/dL and HDL-cholesterol 53.52±15.6 mg/dL. Body fat percentage has a significant correlation with triglyceride (r=0.368; p=0.001), and HDL-cholesterol levels (r=-0.307; p=0.006 ) just in subject with polymorphism, but does not have a significant correlation with another biomarker. Conclusion: Body fat percentage correlates with triglyceride and HDL cholesterol in Minangkabau premenopausal women who have polymorphism of TERT Gene. BACKGROUND: Cardiometabolic disease risk is increasing in the premenopausal phase of women life. The telomerase reverse transcriptase (TERT) gene is a gene that plays a role in protecting telomeres from progressive shortening. Telomere shortening is associated with the incidence of cardiometabolic disease. AIM: This study aims to elucidate the relationship body fat percentage with the modifiable risk factors of cardiometabolic disease in Minangkabau premenopausal people. METHODS: A cross-sectional study was conducted in 111 Minangkabau premenopausal people aged 40–55 years old at Padang City in West Sumatera, Indonesia. Body fat percentage analyzed by bioelectrical impedance analyzer. Fasting blood glucose and lipid profile were examined from venous blood. Polymorphism of the TERT rs2736098 gene was analyzed by a polymerase chain reaction. Data were analyzed using Spearman’s rank correlation test with significant levels p < 0.05. RESULTS: Average body fat percentage of subjects was 36.23 ± 6.9, fasting blood glucose was 101.52 ± 12.3 mg/dL; total cholesterol was 193.99 ± 41.5 mg/dL; triglyceride was 113.76 ± 37.9 mg/dL; LDL-cholesterol was 120.59 ± 45.7 mg/dL and HDL-cholesterol was 53.52±15.6 mg/dL. Body fat percentage has a significant correlation with triglyceride (r = 0.368; p = 0.001) and HDL-cholesterol levels (r = −0.307; p = 0.006) just in subject with polymorphism but does not have a significant correlation with another biomarker. CONCLUSION: Body fat percentage correlates with triglyceride and HDL cholesterol in Minangkabau premenopausal women who have polymorphism of TERT gene

Correlation between saturated fatty acid intake and superoxide dismutase activities with telomere length in Minangkabau ethnic men

Background: Non-communicable diseases (NCD) are the leading cause of death globally today. In West Sumatra there has been an increase in NCD which exceeds the national average percentage. Telomere shortening is associated with occurrence of NCD. Shortening of telomeres is influenced by diet. The purpose of this study was to examine the relationship between Saturated Fatty Acid (SAFA) intake and Superoxide Dismutase (SOD) activity with the telomere length of Minangkabau ethnic men.Methods: This study was a cross sectional study. The sample of this study were 69 civil servants of Minangkabau male at district office in the Padang City, aged 40-50 years and according to the inclusion and exclusion criteria. Data on SAFA intake was obtained using Semi Quantitative Food Frequency Questionnaire (SQFFQ), SOD activity was measured using the Calorimetric method and telomere length was measured using Real Time Polymerase Chain Reaction (RT-PCR) by O’Challaghan and Fennech method. Data analysis was performed using Pearson correlation test with significance level p <0.05.Results: The results showed an average SAFA intake 10.47+3.46% calories, SOD activity 5.93+0.81units/ml and telomere length 468.94+199.25bp. Correlation test between telomere length with SAFA intake showed (p=0.338), and the correlation test between SOD activity and telomere length showed (p=0.01).Conclusions: From this study it was concluded that there was no correlation between SAFA intake and telomere length and there was a significant positive correlation between SOD activity and the telomere length of Minangkabau ethnic men

Differences in the Effect of Giving Fe Tablets and Capsules Moringa Leaves on Hepcidin and Ferritin Levels in Anemic Pregnancy Rats

Anemia is a condition characterized by a decrease in Hemoglobin (HB), a serious global public health problem especially affecting children and pregnant women. This study aimed to determine differences in the effect of giving Fe tablets and capsules of Moringa leaves on hepcidin and ferritin levels in anaemic pregnancy rats. This research was an experimental study with a randomized post-test-only control group design. This research was conducted at the Animal House of the Faculty of Medicine, Andalas University to maintain and treat experimental animals. Ferritin and Hepcidin examinations were carried out at the biomedical laboratory of the Faculty of Medicine, Andalas University. The sample in this study were female white rats (Rattus Novergicus) which met the inclusion and exclusion criteria, the data were analyzed using One Way Anova. The results of this study indicated that the mean hepcidin levels in the Fe (P1) and Moringa leaf capsule (P2) groups were 181.902 ± 20.31 and 216.362 ± 29.90 with a p-value of 0.006 . The mean ferritin levels in the Fe(P1) and Moringa leaf capsule (P2) groups were 1.928 ± 0.263 and 2.308 ± 0.320 with a p-value of 0.004. The conclusion in this study was that there was an effect on hepcidin levels after being given Fe tablets (P1) and Moringa leaf capsules (P2) to anemic pregnant rats and there was an effect on ferritin levels after being given Fe tablets (P1) and Moringa leaf capsules (P2) to anemic pregnant rats Keyword: Anemic, Ferritin, Fe Tablets, Hepcidin, Moringa Leaf Capsule

Association between carbohydrate consumption with telomere length based on plasma malondialdehyde in Minangkabau male

Background: Life expectancy was one indicator of human development index in the health sector, one of which was affected by the telomere shortening process. There were many factors that cause shortening of telomere, including an imbalance of carbohydrate consumption then oxidative stress. The study aimed to examine the association between carbohydrate and carbohydrate simplex (sucrose) consumption with telomere length based on plasma malondialdehyde in Minangkabau male.Methods: The study was cross-sectional with 97 samples from male civil servant, Minangkabau ethnic, 40-50 years old in Padang City. Carbohydrate and sucrose consumptions were obtained through semiquantitative food frequency questionnaire, plasma malondialdehyde examination with thiobarbituric acid test and telomere length measured by quantitative polymerase chain reaction using O'Challagan and Fenech method.Results: The result showed mean of telomere length was 550.43±188.47 bp; mean of carbohydrate consumption 1280.97±433.57 kcal or 48.80±16.52%; mean of sucrose consumption 179.40±126.61 kcal or 6.83±4.82% and mean plasma malondialdehyde 66.91±13.93 nmol/ml. The association of carbohydrate consumption with telomere length based on plasma malondialdehyde was obtained p-value = 0.714, 0.908 and 0.903. The relationship of sucrose consumption with telomere length based on malondialdehyde was obtained p-value=0,667 and 1,000. Differences in mean telomere length in various categories of carbohydrate and sucrose consumption obtained p-value = 0.547 and 0.559.Conclusions: There was no significant association between carbohydrate and carbohydrate simplex (sucrose) consumption with telomere length based on plasma malondialdehyde of Minangkabau male; and no significant difference in telomere length in different categories of carbohydrate consumption and different sucrose consumption