Copper(II) complexes of methimazole, an anti Grave’s disease drug : Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor

Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)2·H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated.Centro de Química Inorgánic

Multiple thermochronometers applied to the quantitative analysis of compressive systems: The southern sub-Andean fold and thrust belt of Bolivia: From source rock to trap

The evolution of fold and thrust belts requires time data restrictions to determine the rates related to the interaction of surface and subsurface processes and to quantify the time relationship between the components of the petroleum system: reservoir, seal, source rock and trap. The sub-Andean fold-and-thrust belt in the Bolivian territory in general, and the regional transect that links the structures of Curuyuqui-Carohuaicho-Tatarenda-Borebigua-Charagua and Mandeyapecua in particular, constitutes a complex multi-variable system in which the definition of time-Temperature (t-T) trajectories has led to new suitable structural and stratigraphic conclusions. The integration of multiple thermochronological-geochronological systems (Apatite Fission Track, Apatite (U-Th-Sm)/He and UPb SHRIMP on zircon) and the existing surface and subsurface geological constraints made it possible to develop a chrono-kinematic characterization of fault-related anticlines, defining their formation chronology, structural growth rate and link between them in the study area. Furthermore, it was also possible to perform a quantitative analysis of the subsidence-burial and exhumation-erosion phenomena that occurred from the deposition of Silurian-Devonian source rocks to the present time, providing relevant determinations to the modeling of the Oil & Gas system.Fil: Hernandez, Juan I.. Geomap S.a.; ArgentinaFil: Hernández, Roberto M.. Geomap S.a.; ArgentinaFil: Dalenz Farjat, Alejandra. Geomap S.a.; ArgentinaFil: Cristallini, Ernesto Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Geología. Laboratorio de Modelado Geológico; ArgentinaFil: Alvarez, Luis A.. Geomap S.a.; ArgentinaFil: Dellmans, Luis M.. Geomap S.a.; ArgentinaFil: Costilla, Marcos Roberto. Geomap S.a.; ArgentinaFil: Alvarez, Andres F.. Geomap S.a.; ArgentinaFil: Becchio, Raul Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Bio y Geociencias del NOA. Universidad Nacional de Salta. Facultad de Ciencias Naturales. Museo de Ciencias Naturales. Instituto de Bio y Geociencias del NOA; ArgentinaFil: Bordese, Sofia. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; ArgentinaFil: Arzadún, Guadalupe. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Guibaldo, Cristina. lA - Te Andes S.A. Laboratorio de Termocronología de Los Andes; ArgentinaFil: Glasmacher, Ulrich A.. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Tomezzoli, Renata Nela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Ecología, Genética y Evolución de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Ecología, Genética y Evolución de Buenos Aires; ArgentinaFil: Stockli, Daniel F.. University of Texas; Estados UnidosFil: Fuentes, Facundo. YPF - Tecnología; ArgentinaFil: Soria Galvarro, Jaime. YPF - Tecnología; ArgentinaFil: Rosales, Adolfo. YPF - Tecnología; ArgentinaFil: Dzelalija, Francisco. YPF - Tecnología; ArgentinaFil: Haring, Claudio. YPF - Tecnología; Argentin