Ferromagnetic 0-pi Junctions as Classical Spins

The ground state of highly damped PdNi based 0-pi ferromagnetic Josephson junctions shows a spontaneous half quantum vortex, sustained by a supercurrent of undetermined sign. This supercurrent flows in the electrode of a Josephson junction used as a detector and produces a phi(0)/4 shift in its magnetic diffraction pattern. We have measured the statistics of the positive or negative sign shift occurring at the superconducting transition of such a junction. The randomness of the shift sign, the reproducibility of its magnitude and the possibility of achieving exact flux compensation upon field cooling: all these features show that 0-pi junctions behave as classical spins, just as magnetic nanoparticles with uniaxial anisotropy.Comment: 4 pages, 4 figure

Conductance fluctuations in metallic nanogaps made by electromigration

We report on low temperature conductance measurements of gold nanogaps fabricated by controlled electromigration. Fluctuations of the conductance due to quantum interferences and depending both on bias voltage and magnetic field are observed. By analyzing the voltage and magnetoconductance correlation functions we determine the type of electron trajectories generating the observed quantum interferences and the effective characteristic time of phase coherence in our device.Comment: 5 pages, 4 figures, to appear in J. Appl. Phy

Measurement of the current-phase relation of superconducting atomic contacts

We have probed the current-phase relation of an atomic contact placed with a tunnel junction in a small superconducting loop. The measurements are in quantitative agreement with the predictions of a resistively shunted SQUID model in which the Josephson coupling of the contact is calculated using the independently determined transmissions of its conduction channels.Comment: to be published in Physical Review Letter

Critical currents of MgB2 thin films depositedin situby sputtering

We have measured the temperature and magnetic field dependencies of the critical current density J(c)(H,T) in MgB2 thin films, in situ deposited by sputtering. Three-dimensional point like normal core pinning was evidenced by measurements of the magnetic dependence of the pinning forces independently from the superconducting and structural quality of the investigated films. The analysis of the experimental data in terms of the collective pinning model has pointed out the presence of a crossover magnetic field from a single vortex to a small vortex bundle pinning regime. A DeltaT(c) pinning mechanism, i.e., a pinning associated with spatial fluctuations of the transition temperature, has been evidenced by the temperature dependence of this crossover field, in agreement with previous observations performed on MgB2 bulk materials

Synthesis and characterisation of a new benzamide-containing nitrobenzoxadiazole as a GSTP1-1 inhibitor endowed with high stability to metabolic hydrolysis

The antitumor agent 6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexan-1-ol (1) is a potent inhibitor of GSTP1-1, a glutathione S-transferase capable of inhibiting apoptosis by binding to JNK1 and TRAF2. We recently demonstrated that, unlike its parent compound, the benzoyl ester of 1 (compound 3) exhibits negligible reactivity towards GSH, and has a different mode of interaction with GSTP1-1. Unfortunately, 3 is susceptible to rapid metabolic hydrolysis. In an effort to improve the metabolic stability of 3, its ester group has been replaced by an amide, leading to N-(6-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)thio)hexyl)benzamide (4). Unlike 3, compound 4 was stable to human liver microsomal carboxylesterases, but retained the ability to disrupt the interaction between GSTP1-1 and TRAF2 regardless of GSH levels. Moreover, 4 exhibited both a higher stability in the presence of GSH and a greater cytotoxicity towards cultured A375 melanoma cells, in comparison with 1 and its analog 2. These findings suggest that 4 deserves further preclinical testing