Caffeine Impairs Myocardial Blood Flow Response to Physical Exercise in Patients with Coronary Artery Disease as well as in Age-Matched Controls

BACKGROUND: Caffeine is one of the most widely consumed pharmacologically active substances. Its acute effect on myocardial blood flow is widely unknown. Our aim was to assess the acute effect of caffeine in a dose corresponding to two cups of coffee on myocardial blood flow (MBF) in coronary artery disease (CAD). METHODOLOGY/PRINCIPAL FINDINGS: MBF was measured with (15)O-labelled H2O and Positron Emission Tomography (PET) at rest and after supine bicycle exercise in controls (n = 15, mean age 58+/-13 years) and in CAD patients (n = 15, mean age 61+/-9 years). In the latter, regional MBF was assessed in segments subtended by stenotic and remote coronary arteries. All measurements were repeated fifty minutes after oral caffeine ingestion (200 mg). Myocardial perfusion reserve (MPR) was calculated as ratio of MBF during bicycle stress divided by MBF at rest. Resting MBF was not affected by caffeine in both groups. Exercise-induced MBF response decreased significantly after caffeine in controls (2.26+/-0.56 vs. 2.02+/-0.56, P<0.005), remote (2.40+/-0.70 vs. 1.78+/-0.46, P<0.001) and in stenotic segments (1.90+/-0.41 vs. 1.38+/-0.30, P<0.001). Caffeine decreased MPR significantly by 14% in controls (P<0.05 vs. baseline). In CAD patients MPR decreased by 18% (P<0.05 vs. baseline) in remote and by 25% in stenotic segments (P<0.01 vs. baseline). CONCLUSIONS: We conclude that caffeine impairs exercise-induced hyperaemic MBF response in patients with CAD to a greater degree than age-matched controls

In situ observations of the Swiss periglacial environment using GNSS instruments

Monitoring of the periglacial environment is relevant for many disciplines including glaciology, natural hazard management, geomorphology, and geodesy. Since October 2022, Rock Glacier Velocity (RGV) is a new Essential Climate Variable (ECV) product within the Global Climate Observing System (GCOS). However, geodetic surveys at high elevation remain very challenging due to environmental and logistical reasons. During the past decades, the introduction of low-cost global navigation satellite system (GNSS) technologies has allowed us to increase the accuracy and frequency of the observations. Today, permanent GNSS instruments enable continuous surface displacement observations at millimetre accuracy with a sub-daily resolution. In this paper, we describe decennial time series of GNSS observables as well as accompanying meteorological data. The observations comprise 54 positions located on different periglacial landforms (rock glaciers, landslides, and steep rock walls) at altitudes ranging from 2304 to 4003 ma.s.l. and spread across the Swiss Alps. The primary data products consist of raw GNSS observables in RINEX format, inclinometers, and weather station data. Additionally, cleaned and aggregated time series of the primary data products are provided, including daily GNSS positions derived through two independent processing tool chains. The observations documented here extend beyond the dataset presented in the paper and are currently continued with the intention of long-term monitoring. An annual update of the dataset, available at https://doi.org/10.1594/PANGAEA.948334 (Beutel et al., 2022),​​​​​​​ is planned. With its future continuation, the dataset holds potential for advancing fundamental process understanding and for the development of applied methods in support of e.g. natural hazard management

Hemodynamics.

<p>DBP = diastolic blood pressure (BP); HR = heart rate; MAP = mean BP; RPP = rate pressure product; SBP = systolic BP.</p><p>P-values are given for the comparison of baseline vs. caffeine.</p

Myocardial Blood Flow, Coronary Resistance and Flow Reserve.

<p>MBF, myocardial blood flow (ml/min/g). Cor Res, coronary resistance (mmHg/ml/min/g). MPR, myocardial perfusion reserve (relative values). Ex, exercise.</p>*<p>P<0.05 for the comparison with remote segments.</p>†<p>P<0.05 for the comparison with age-matched controls.</p

Exercise-induced hyperemia: effects of caffeine.

<p>Caffeine decreases exercise-induced hyperaemic MBF. This effect was most prominent in stenotic segments of CAD patients. *<i>P</i><0.005 for the comparison versus baseline.</p

Myocardial perfusion reserve: effects of caffeine.

<p>Caffeine decreases myocardial perfusion reserve. This effect was most pronounced in stenotic segments of CAD patients. *<i>P</i><0.05 for the comparison versus baseline.</p

Coronary resistance during physical exercise.

<p>Coronary resistance at exercise increased in all groups. A massive increase in resistance was found in stenotic segments. ‡<i>P</i><0.05 for the comparison versus remote. *<i>P</i><0.05 for the comparison versus remote segments and age-matched controls.</p

In situ observations of the Swiss periglacial environment using GNSS instruments

Monitoring of the periglacial environment is relevant for many disciplines including glaciology, natural hazard management, geomorphology, and geodesy. Since October 2022, Rock Glacier Velocity (RGV) is a new Essential Climate Variable (ECV) product within the Global Climate Observing System (GCOS). However, geodetic surveys at high elevation remain very challenging due to environmental and logistical reasons. During the past decades, the introduction of low-cost global navigation satellite system (GNSS) technologies has allowed us to increase the accuracy and frequency of the observations. Today, permanent GNSS instruments enable continuous surface displacement observations at millimetre accuracy with a sub-daily resolution. In this paper, we describe decennial time series of GNSS observables as well as accompanying meteorological data. The observations comprise 54 positions located on different periglacial landforms (rock glaciers, landslides, and steep rock walls) at altitudes ranging from 2304 to 4003  and spread across the Swiss Alps. The primary data products consist of raw GNSS observables in RINEX format, inclinometers, and weather station data. Additionally, cleaned and aggregated time series of the primary data products are provided, including daily GNSS positions derived through two independent processing tool chains. The observations documented here extend beyond the dataset presented in the paper and are currently continued with the intention of long-term monitoring. An annual update of the dataset, available at https://doi.org/10.1594/PANGAEA.948334 (Beutel et al., 2022), is planned. With its future continuation, the dataset holds potential for advancing fundamental process understanding and for the development of applied methods in support of e.g. natural hazard management.ISSN:1866-3516ISSN:1866-350

Kinematic observations of the mountain cryosphere using in-situ GNSS instruments 2010-2021

This dataset collates data of continuously acquired kinematic observations obtained through in-situ Global Navigation Satellite Systems (GNSS) instruments that have been designed and implemented in a large-scale multi field-site monitoring campaign across the whole Swiss Alps. The landforms covered include rock glaciers, high-alpine steep bedrock bedrock as well as landslide sites, most of which are situated in permafrost areas. The dataset was acquired at 54 different stations situated at locations from 2304 to 4003 meter a.s.l and comprises 229'669 daily positions derived through double-differential GNSS post-processing. Apart from these, the dataset contains down-sampled and cleaned time series of weather station and inclinometer data as well as the full set of GNSS observables in RINEX format. Furthermore the dataset is accompanied by tools for processing and data management in order to facilitate reuse, open alternate usage opportunities and support the life-long living data process with updates. All data contained in this data set including updates to newer data can also be retrieved using the toolset available at https://git.uibk.ac.at/informatik/neslab/public/permasense/permasense_datamgr from the online PermaSense data repository at http://data.permasense.ch

Kinematic observations of the mountain cryosphere using in-situ GNSS instruments 2011-2021

This dataset collates data of continuously acquired kinematic observations obtained through in-situ Global Navigation Satellite Systems (GNSS) instruments that have been designed and implemented in a large-scale multi field-site monitoring campaign across the whole Swiss Alps. The landforms covered include rock glaciers, high-alpine steep bedrock bedrock as well as landslide sites, most of which are situated in permafrost areas. The dataset was acquired at 54 different stations situated at locations from 2304 to 4003 meter a.s.l and comprises 209'948 daily positions derived through double-differential GNSS post-processing. Apart from these, the dataset contains down-sampled and cleaned time series of weather station and inclinometer data as well as the full set of GNSS observables in RINEX format. Furthermore the dataset is accompanied by tools for processing and data management in order to facilitate reuse, open alternate usage opportunities and support the life-long living data process with updates